Navigation Links
Low cholesterol transfer protein activity associated with heart disease risk
Date:12/15/2009

BOSTON (December 15, 2009) Although seen as a potential heart disease therapy, raising high-density lipoprotein (HDL) cholesterol levels by inhibiting activity of a transfer protein may not be effective, a new study suggests. Scientists at the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts University and Boston University School of Medicine found an association between low plasma cholesterol ester transfer protein (CETP) activity and increased risk of heart disease in the Framingham Heart Study population.

CETP is a protein that shuttles cholesterol throughout the body, thus controlling the levels of HDL, low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) in the blood. "Our findings differ from studies suggesting that inhibiting CETP activity would bring a cardiovascular benefit by raising HDL, the so-called good cholesterol credited with lowering the risk of heart disease," says senior author Jose Ordovas, PhD, director of the Nutritional Genomics Laboratory at the USDA HNRCA. "In a clinical trial testing that hypothesis, heart disease unexpectedly advanced in a surprising number of participants."

Based on those results, Ordovas and colleagues examined CETP activity in 1,978 Caucasian men and women with a mean age of 51 years and no history of heart disease. They analyzed 15 to 18 years of study visits looking for first cardiac events including heart failure, heart attack, angina, stroke and peripheral vascular disease.

"By the end of the follow-up period, 320 men and women had experienced their first cardiac event," says Ordovas who is also a professor at the Friedman School of Nutrition Science and Policy at Tufts University. "Participants with low CETP activity were 18 percent more likely to develop cardiovascular disease than people with CETP activity above the median."

A more in-depth investigation of models eliminated the possibility that age, sex and common risk f
'/>"/>

Contact: Andrea Grossman
617-636-3728
Tufts University, Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Normal Cholesterol Doesnt Guarantee Healthy Heart
2. Menopause Often Means Worsening Cholesterol
3. Cholesterol-lowering drugs also may protect stem cell transplant patients from GVHD
4. Latest epidemic? High cholesterol, obesity in fruit flies
5. Cholesterol Plays Role in Heart Failure Risk
6. Incidence of High Cholesterol Drops in U.S.
7. Study Raises New Questions About Cholesterol Drug Zetia
8. American Heart Association Late Breaking Clinical Trial Report: In Patients on Statins, Raising Good Cholesterol with Niacin, but not Reducing Bad Cholesterol with Ezetimibe, Decreases Plaque Build-Up
9. New Study Raises New Questions About Cholesterol Drug Zetia
10. Cholesterol Measurements May Be Made Easier
11. Cholesterol and Cancer: Answers and Some New Questions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... Dotinga HealthDay Reporter , MONDAY, ... baldness may face a higher risk of developing an aggressive ... new study suggests. But, the study authors noted that ... of baldness should be concerned. Their study only found an ... did not prove cause and effect. "It is conceivable ...
(Date:9/16/2014)... After working together for eight years and ... fertility centers in the late 1990s and early 2000s, Dr. ... hometown of New York City to launch Chelsea Fertility of ... , Chelsea Fertility NYC offers full service fertility treatment ... New York Tri-State Area, and provides equal access to care ...
(Date:9/16/2014)... New Jersey (PRWEB) September 16, 2014 ... Infinity Development Partners of San Antonio, TX. has been ... Army facilities located throughout the US, including Alaska and ... Army’s Energy Initiatives Task Force (EITF) and the Corps ... a $7 Billion MATOC primarily to fund renewable and ...
(Date:9/16/2014)... Alachua, FL (PRWEB) September 16, 2014 ... technology company focused on the peripheral nerve repair market, ... the American Society for Surgery of the Hand (ASSH) ... John B. Hynes Convention Center in Boston, MA. , ... outcomes in surgical nerve repair, featuring a discussion by ...
(Date:9/16/2014)... September 16, 2014 Much of the ... major extended drought crisis that in many regions affects ... the many individuals who are dedicated to solving the ... solutions overlook large portion of the problem. Partial solutions, ... crises.     , Grigg explained his, “total water management” concept ...
Breaking Medicine News(10 mins):Health News:Male Pattern Baldness Tied to Prostate Cancer, Study Suggests 2Health News:Male Pattern Baldness Tied to Prostate Cancer, Study Suggests 3Health News:Chelsea Fertility NYC Offers New and Affordable Fertility Treatment Options for Patients in the New York Tri-State Area 2Health News:Chelsea Fertility NYC Offers New and Affordable Fertility Treatment Options for Patients in the New York Tri-State Area 3Health News:Chelsea Fertility NYC Offers New and Affordable Fertility Treatment Options for Patients in the New York Tri-State Area 4Health News:Solar Construction Opportunity at U.S Army Installations Awarded to Pfister Energy & Infinity Development 2Health News:AxoGen, Inc. to Host Surgeon Education Event at American Society for Surgery of the Hand 2014 Annual Meeting 2Health News:AxoGen, Inc. to Host Surgeon Education Event at American Society for Surgery of the Hand 2014 Annual Meeting 3Health News:Drought Solutions Overlook Too Many Factors Water Policy Expert Warns Sharon Kleyne 2Health News:Drought Solutions Overlook Too Many Factors Water Policy Expert Warns Sharon Kleyne 3
... men after bypass surgery, according to a new study done ... say whether the //results are due to medical or psychosocial ... outcomes after bypass surgery than men. Most have attributed this ... generally older, sicker, and have fewer social supports. In this ...
... is when symptoms have lasted for less than three ... self-management program that includes group classes, exercise sheet handouts, ... manage their back pain. ,Researchers from Indiana University ... low back pain. The program focuses on boosting confidence ...
... study shows hydrotherapy, or water exercise, may improve strength and ... studied more than 100 patients with osteoarthritis who were older ... first group exercised three times a week in a swimming ... did not exercise at all. Both the water and gym ...
... may improve strength and mobility in patients with osteoarthritis.// ... who were older than age 50. Patients were divided into ... in a swimming pool, the second exercised in a gym, ... water and gym programs focused on resistance exercises. ,Results ...
... lasted for less than three months. ,A new study ... sheet// handouts, and telephone follow-up calls may help patients ... from Indiana University developed a self-management program for poor, ... on boosting confidence in order to increase their motivation ...
... reducing the signs of aging in the neck. The procedure involves ... reduce the saggy appearance of the neck. Researchers say this new ... are often changes in the neck and face including the loss ... of fat in the neck. This causes the skin to sag. ...
Cached Medicine News:
(Date:9/16/2014)... LONDON , Sept. 16, 2014 ... wound closure market, Frost & Sullivan recognises Incisive ... Award for Customer Value Leadership. Incisive Surgical,s uniquely-designed, ... closure technology that eliminates the need for patients ... punctures and staple removal  that may result in ...
(Date:9/16/2014)... , Sept. 16, 2014 CorMedix Inc. ... on developing and commercializing therapeutic products for the ... diseases, announces the amendment and restatement of its ... stock and related warrants, as well as the ... and warrant financing, to remove anti-dilution, price reset ...
(Date:9/16/2014)...  DNAtrix, Inc., experts in oncolytic virus development, ... with the company,s lead product, DNX-2401, a replication ... multicenter, open-label Phase Ib study for patients with ... leading neurosurgeons and neuro-oncologists in the US, is ... Phase Ib study of DNX-2401 at Moffitt Cancer ...
Breaking Medicine Technology:Frost & Sullivan Commends Incisive Surgical for Delivering Superior Customer Value through its Patient-Centric, Cost-Effective INSORB Absorbable Stapler 2Frost & Sullivan Commends Incisive Surgical for Delivering Superior Customer Value through its Patient-Centric, Cost-Effective INSORB Absorbable Stapler 3Frost & Sullivan Commends Incisive Surgical for Delivering Superior Customer Value through its Patient-Centric, Cost-Effective INSORB Absorbable Stapler 4Frost & Sullivan Commends Incisive Surgical for Delivering Superior Customer Value through its Patient-Centric, Cost-Effective INSORB Absorbable Stapler 5CorMedix Amends and Restates Outstanding Securities to Remove Provisions Causing Derivative Liability Classification 2CorMedix Amends and Restates Outstanding Securities to Remove Provisions Causing Derivative Liability Classification 3DNAtrix Announces Treatment Of First Patient With DNX-2401 In Recurrent Glioblastoma Trial 2
... ALTO, Calif., Dec. 21, 2010 Jazz Pharmaceuticals, Inc. ... United States Patent and Trademark Office (USPTO) has issued ... titled "Microbiologically Sound and Stable Solutions of Gamma-Hydroxybutyrate Salt ... 7,851,506, is also listed in the FDA,s Approved Drug ...
... Today, Pepex Biomedical, Inc. announced that the company has ... Therapeutic Discovery Project created by Congress as a component ... 2010, the major health care reform bill, signed into ... submitted their ground-breaking, patented, electrochemical biosensor, nanotechnology and the ...
Cached Medicine Technology:Jazz Pharmaceuticals Announces New Patent Issued for Sodium Oxybate 2Pepex™ Awarded Qualifying Therapeutic Discovery Project Grant 2
Inquire...
... Roches patented polymerase chain reaction (PCR) ... technology, is an essential component of Roches ... PCR allows minute amounts of selected unique ... into billions of copies (that is, to ...
... Introducing BenchMark XT® the only fully ... flexibility you need to expand your ... improve your slide turnaround time. All ... choose how to use the BenchMark ...
... Reicherts new ATP Auto Non-Contact Tonometer / ... / pachymeter, combining the measurement of IOP ... response to numerous clinical studies that have ... thickness as well as intraocular pressure in ...
Medicine Products: