Low-carb diets alter glucose formation by... (stable group who consumed carbohydrates ...)

Low-carb diets alter glucose formation by the liver

Date:10/20/2008

stable group, who consumed carbohydrates as a significant proportion of their diet, the TCA cycle alone provided sufficient energy to drive glucose formation. "This was not the case in individuals undergoing carbohydrate restriction," the authors report.

Carbohydrate restriction increased the rate of glucose formed using lactate or amino acids (GNGpep). "This suggests that in fasted human subjects undergoing weight loss, the elevated gluconeogenesis associated with carbohydrate restriction is driven by substrates such as lactate or amino acids," the authors report. In spite of this, TCA cycle flux in the low-carbohydrate group was similar to the low-calorie group, indicating similar rates of energy generation.

In contrast to previous reports, the present study showed similar hepatic glucose production among the dietary groups. The low-carbohydrate group was able to maintain hepatic glucose production at the levels observed for the weight-stable and low-calorie groups by increasing glucose formation using lactate or amino acids to match the reduction in glucose formation from glycerol.

"This observation is reminiscent of 'hepatic autoregulation' by which endogenous glucose production remains unchanged in the setting of altered gluconeogenesis or glycogenolysis because the two pathways tend to compensate for each other," the authors report.

They noted it was interesting that the increased glucose formation using lactate or amino acids in the low-carbohydrate group was not associated with increased TCA cycle flux (i.e. energy production.) However, they did not measure absolute rates of fatty acid delivery to the liver or ketone body production, limiting their ability to further interpret that finding.

"We have shown that the sources from which endogenous glucose is produced are dependent upon dietary macronutrient composition," the authors write. They suggest that the shift in glucose metabolism associated with a low carb
'/>"/>

Contact: Sean Wagner
swagner@wiley.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

1

GOOD

Page: 1 2 3
Related medicine news :

1. Low-Carb Diets Better Than Low-Fat Diets at Preventing Diabetes
2. Diabetes Group Backs Low-Carb Diets
3. Low-carb diet reduces inflammation and blood saturated fat in metabolic syndrome
4. Low-Carb Diet May Slow Prostate Tumor Growth
5. A low-carb diet may stunt prostate tumor growth
6. Phone World-famed Martin Schiff, M.D., at 310-454-6172 for Free Weight Loss No Diet, No Stuff Method. Hates Diets, Loves to Have People Help Themselves
7. eDiets.com(R) Announces Q2 2008 Results
8. Whos Who Weight Specialist Martin Schiff, M.D., 86, Devoting Rest of Life to Spreading Truth About Diets, Wont Accept Compensation From Anyone, Sending Complete Guide Free to All
9. NEJM: Low-fat diets not best for weight loss: New study by Ben-Gurion U. of the Negev
10. Survey Indicates Lifestyle Change Is More Important Than Diets
11. eDiets.com(R) Appoints New Chief Information Officer Laura Klein

Post Your Comments:

Low-carb diets alter glucose formation by...(stable group who consumed carbohydrates ...),Health