Navigation Links
Low adiponcetin associated with increased pancreatic cancer risk
Date:12/14/2012

Low prediagnostic levels of circulating adiponectin were associated with an increased risk of pancreatic cancer, according to a study published December 14 in the Journal of the National Cancer Institute.

Pancreatic cancer is the fourth leading cause of cancer death in the U.S., but its etiology remains unclear. Adiponectin, a hormone secreted from fat cells, has insulin-sensitizing and anti-inflammatory properties. Low adiponectin plasma levels are associated with the insulin resistance that manifests in obesity and diabetes mellitus, both of which are risk factors for pancreatic cancer.

In order to determine if prediagnostic plasma levels of adiponectin were linked to an increased risk of pancreatic cancer, Ying Bao, M.D., Sc.D., Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and colleagues, pooled the data from five prospective U.S. cohort studies, and matched 468 pancreatic cancer case subjects with 1,080 healthy control subjects by cohort, year of birth, smoking status, fasting status, and month of blood draw. They assessed the association between adiponectin and pancreatic cancer risk with conditional logistic regression.

The researchers found a statistically significant inverse association between prediagnostic plasma adiponectin levels and the risk of pancreatic cancer in the five prospective cohorts. "Our data provide additional evidence for a biological link between obesity, insulin resistance, and pancreatic cancer risk and also suggest an independent role of adiponectin in the development of pancreatic cancer," the authors write.

In an accompanying editorial, Jianliang Zhang, Ph.D., Associate Professor of Oncology and Steven N. Hochwald, M.D., Department of Surgical Oncology, both of the Roswell Park Cancer Institute, write that the study establishes a link between adiponectin levels and pancreatic cancer risk that suggests that metabolism contributes to the pathophysiology of pancreatic cancer. "Early detection by the assessment of adiponectin has the potential to improve the survival rates of pancreatic tumor patients," the authors write. "It is also inviting to speculate that therapeutic interventions to increase the levels of circulating adiponectin may prevent the development of pancreatic cancer and/or improve the survival of patients with malignancy."


'/>"/>

Contact: Zachary Rathner
Zachary.Rathner@oup.com
301-841-1286
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Team solves mystery associated with DNA repair
2. Cleveland Clinic researcher identifies 2 new genetic mutations associated with Cowden syndrome
3. Study suggests vision insurance associated with eye-care visits, better reported vision
4. Pitt research sheds new light on virus associated with developmental delays and deafness
5. Study suggests eliminating Medicare consultation payments associated with a net increase in spending
6. Migraine-associated brain changes not related to impaired cognition
7. Housing quality associated with childrens burn injury risk
8. Starchy, high carbohydrate diet associated with recurrence of colon cancer
9. Controlling depression is associated with improved health for heart-failure patients
10. Study suggests too much risk associated with SSRI usage and pregnancy
11. Decline in incidence of heart attacks appears associated with smoke-free workplace laws
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... healthcare compliance program management, will showcase a range of technology and learning solutions ... Living (NCAL) Convention and Expo to be held October 14–18, 2017 at the ...
(Date:10/12/2017)... ... 12, 2017 , ... Planet Fitness, one of the largest and fastest growing ... open a flagship location in Covington, LA at 401 N. U.S. Highway 190, in ... to Office Depot in the Holiday Square shopping center. Its location allows it to ...
(Date:10/12/2017)... ... 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of ... innovative new design of the shoulder pad. The shoulder pad provides optimal support ... your pain while using cold therapy. By utilizing ice and water that is circulated ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... a leader in post-acute health care, have expanded their existing home health joint ... Health. , AccentCare has been operating a joint venture home health company with ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... 2017  In response to the nationwide opioid ... Surgeons (AAOMS) released prescribing recommendations that urge ibuprofen ... as a first-line therapy to manage a patient,s ... Recognizing the value and importance of ... Prescribing: Acute and Postoperative Pain Management" stresses that ...
(Date:10/4/2017)... 4, 2017 OBP Medical , ... medical devices, today announced regulatory approval from ... (or Agência Nacional de Vigilância Sanitária (ANVISA)) to ... surgical retractor with integrated LED light source and ... and exposure of a tissue pocket or cavity ...
(Date:10/2/2017)... -- AllianceRx Walgreens Prime, the combined central specialty pharmacy and ... manager Prime Therapeutics LLC (Prime), today officially began the ... of new signage at its headquarters in ... few other company-owned facilities across the country. This also ... whom will begin to see the AllianceRx Walgreens Prime ...
Breaking Medicine Technology: