Navigation Links
Low Thyroid Function Linked to Heart Failure Risk
Date:9/22/2008

Researchers pinpoint what level signals danger

MONDAY, Sept. 22 (HealthDay News) -- A new study can help doctors decide when to treat people who have an underactive thyroid gland that does not cause symptoms strong enough to arouse worry, researchers report.

As many as 27 million Americans have some type of thyroid disease, according to the American Association of Clinical Endocrinologists; about half of these people are undiagnosed.

"At this point, how to manage older people who have subclinical thyroid dysfunction isn't clear," said Dr. Anne R. Cappola, an assistant professor of medicine and epidemiology at the University of Pennsylvania and a member of the group reporting the finding in the Sept. 30 issue of the Journal of the American College of Cardiology.

Cappola and her colleagues looked at one possible result of abnormal thyroid activity, the development of heart failure. They followed more than 3,000 people for an average of 12 years, monitoring thyroid activity by measuring blood levels of thyroid-stimulating hormone (TSH), looking for a relationship between thyroid activity and heart failure, the progressive loss of the ability of the heart to pump blood.

TSH is a hormone produced by the pituitary gland that stimulates thyroid activity. A high TSH reading means that the pituitary is working hard to get the thyroid into action.

A clear indicator of danger emerged from the study, Cappola said: a TSH level of 10 mU/liter. A normal TSH level is 4.5 mU/l or lower.

Study participants with a TSH reading of 10 or higher had about twice the incidence of heart failure as those with lower readings. "Between 4.5 and 10, there was no effect," Cappola said.

The term "subclinical" can mean simply that thyroid problems are being ignored, said Dr. Anne B. Newman, a professor of epidemiology and medicine at the University of Pittsburgh and another member of the research team.

"It is subclinical in the sense that no one has checked it before, and if you do more screening, the chances are that people will show up in the office with hypothyroidism [low thyroid function]," Newman said.

People with low thyroid function can feel very tired, gain excess weight, have a puffy look and slow down in general, she said, phenomena that are not uncommon among older people.

"The reason we looked at this is that there has been a question about whether you really need to start treatment to replace the thyroid hormone with more modest levels of TSH," Newman said. "We didn't see an increased risk of heart disease with readings under 10."

Treatment of low thyroid function is thyroid replacement hormone, "a single small pill once a day, adjusted to body size and metabolism," she said.

Hypothyroidism can be difficult for a physician to detect unless a screening blood test is done, and that test is not done by many physicians who deal with older people, Newman said.

"I think the rate of hypothyroidism is high enough to make it worth while to screen for it," she said.

This study alone is not enough to support treatment for anyone with a TSH reading of 10 or higher, Cappola said. "We're reluctant to recommend that with an observational study," she said. "But this is, clinically, more evidence that someone with a TSH level 10 or above should be treated."

More information

Learn about thyroid problems and their treatment from the U.S. National Library of Medicine.



SOURCES: Anne R. Cappola, assistant professor, medicine and epidemiology, University of Pennsylvania, Philadelphia; Anne B. Newman, M.D., professor, epidemiology and medicine, University of Pittsburgh; Sept. 23, 2008, Journal of the American College of Cardiology


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. PREOS(R) Granted U.S. Orphan Drug Status for Treatment of Hypoparathyroidism
2. Fluoride Damages the Thyroid, Report Shows
3. Thyroid Test Wont Help Pregnant Mom, Baby
4. Better detection accounts for increase in cases of thyroid cancer
5. Thyroid treatment no quick fix for weight loss in children
6. Early detection critical in treating pediatric thyroid cancer
7. Mailman School PH study finds increase in thyroid diseases risk from exposure at Chernobyl
8. Combination of Thyroid Medicines Not Necessary
9. Newly discovered role of thyroid hormone during pregnancy
10. Does artificial intelligence help clinicians to recognize atrophic gastritis with thyroid disease?
11. Thyroid Hormone Could One Day Treat Osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Low Thyroid Function Linked to Heart Failure Risk
(Date:2/11/2016)... Island, NY (PRWEB) , ... February 11, 2016 ... ... has enhanced and updated its hallmark resource, Infusion Therapy Standards of Practice, to ... leader in vein illumination with an estimated 85% share of the market, facilitates ...
(Date:2/11/2016)... ... February 11, 2016 , ... The annual list showcases the 20 Most Promising ... team dedication and commitment to the SharePoint ecosystem. A panel of experts and ... goal is to recognize and promote technology entrepreneurship. , The survey was made ...
(Date:2/11/2016)... , ... February 11, 2016 , ... ... dynamometers and ergoFET force gauges used in physical therapy, occupational therapy and sports ... sensor for resistance cord exercise and therapy, introduces its new microFET Digital Pinch ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... coverage results in significantly higher rates of several common cancer screenings, especially among ... in better outcomes and survival rates. , The study,“What Does Medicaid Expansion ...
(Date:2/10/2016)... ... February 10, 2016 , ... Sherly Sulaiman, certified clinical ... of therapeutic sessions to help Los Angeles-area actors cope with rejection, improve their ... series, known as “Mindfulness for Actors and Artists,” has been featured in ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Fla. , Feb. 11, 2016 PLAD, ... started out 2016 with sales exceeding company targets, are ... have received their trademark from the United States Patent ... Bobby Clark , Chief Executive Officer of PLAD, Inc.  ... of Pennsylvania with two new ...
(Date:2/11/2016)... Feb. 11, 2016  Delcath Systems, Inc. (NASDAQ: ... device company focused on oncology with an emphasis ... cancers, announces the engagement of Lars E. ... Medical Consultant. Dr. Birgerson will provide strategic medical ... operations team to help ensure timely facilitation of ...
(Date:2/11/2016)... ENGLEWOOD, Colo. , Feb. 11, 2016  Aytu ... on developing treatments for urological and related conditions, announced ... for the second fiscal quarter of 2016 on Tuesday, ... will review recent accomplishments and provide an overview of ... financial results for the quarter ended December 31, 2015. ...
Breaking Medicine Technology: