Navigation Links
Low Levels of Brain Chemical May Control Appetite
Date:8/27/2008

Finding could lead to new drugs in fight against obesity, study says

WEDNESDAY, Aug. 27 (HealthDay News) -- A chemical produced in the brain may play a role in regulating appetite and the likelihood of becoming obese, according to a new study.

For the study, researchers looked at a group of 33 people who had WAGR syndrome, a genetic condition that occurs in one in 500,000 to a million people. WAGR is an acronym for the symptoms that accompany the condition: Wilms' tumor (tumor of the kidneys), aniridia (absence of the iris), genital and urinary tract abnormalties, and mental retardation.

Some people with WAGR syndrome lack a gene for the brain chemical, brain-derived neurotrophic factor (BDNF). Animal studies have suggested that BDNF may help control appetite and weight.

The researchers found that 19 (58 percent) of the 33 study participants had deletions of all or a major proportion of one copy of the gene for BDNF and had correspondingly low blood levels of BDNF.

These 19 participants were all obese by age 10 and had a strong tendency to overeat. The participants who had two working copies of the BDNF gene, on the other hand, were no more likely to develop obesity in childhood than the general population and did not report unusually high levels of overeating.

"This is a promising new lead in the search for biological pathways that contribute to obesity," Dr. Duane Alexander, director of the U.S. National Institute of Health's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), said in an institute press release. "This finding may eventually lead to the development of new drugs to regulate appetite in people who have not had success with other treatments."

The findings are published in the Aug. 28 issue of the New England Journal of Medicine.

According to senior study author Dr. Jack A. Yanovski, of the NICHD's Unit on Growth and Obesity, BDNF is thought to work in combination with a variety of other substances that regulate appetite and body weight, including the appetite-signaling hormone leptin.

Future research looking into the relationship between BDNF and leptin may lead to the development of new therapies for obesity.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about obesity.



-- Krisha McCoy



SOURCE: U.S. National Institute of Child Health and Human Development, news release, Aug. 27, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. The Highlands at Wyomissing Invests in Voice-Assisted Care to Take Excellence in Retirement Living to New Levels
2. Earthjustice/EIP Report: Dangerous Mercury Pollution From Unregulated Cement Kilns in U.S. About Twice as High as Levels Previously Projected by EPA
3. CSHL scientists correlate enzyme expression levels with chemotherapy drug response
4. Low Iron Levels Cut Cancer Risk in Men With PAD
5. FTC Acts to Prevent Tobacco Industry Deception About Tar, Nicotine Levels; Congress Should Go Further by Giving FDA Authority Over Tobacco Products
6. Moms Vitamin D Levels Affect Babys Dental Health
7. American Lung Association Urges People Living Near Wildfires to Protect Themselves Against Staggering Levels of Unhealthy Air Pollution
8. Research Links Low HDL Levels With Memory Loss
9. UK and US guidelines on kids physical activity levels need rethinking
10. Overcrowding and understaffing in hospitals increases levels of MRSA infections
11. Local Blood Supply at Low Levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... (PRWEB) , ... August 22, 2017 , ... “Wilderness Voices”: ... of world travel. “Wilderness Voices” is the creation of published author, Martha McKown, ... Martha McKown was inspired as a very young child when her older sisters studied ...
(Date:8/22/2017)... , ... August 22, 2017 , ... ... Stewart is the Founder and Managing Member for t4 Leadership Development & Consulting. ... critical to his definition of “success”: physician leadership development, servant leadership, data driven ...
(Date:8/21/2017)... (PRWEB) , ... August 22, 2017 , ... PracticeMatch, a ... to help healthcare employers connect with physicians and advanced practitioners like nurse practitioners ... career fairs in August through November of this year. The online career fairs ...
(Date:8/21/2017)... , ... August 21, 2017 , ... FCPX LUT Monochromatic ... Editors can quickly and easily add washed color grades to footage. A LUT is ... changes every pixel’s color to the corresponding color indicated by the table. This pack ...
(Date:8/21/2017)... ... August 21, 2017 , ... Duncan Insurance Agency ... the people of Michigan. The new initiative fundraises for the Kalamazoo Humane Society ... forefront of animal protection and welfare by addressing the root causes of pet ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... 7, 2017 Zimmer Biomet Holdings, Inc. (NYSE and ... that its Board of Directors has approved the payment of ... of 2017. The cash ... about October 27, 2017 to stockholders of record as of ... of dividends are subject to approval of the Board of ...
(Date:8/4/2017)... The search for test results that can ... has long been the goal of healthcare providers and ... the largest meeting of lab professionals and IVD firms ... firm Kalorama Information.  The firm said scores of companies ... supplies and software were at the American Association for ...
(Date:8/2/2017)... BENTON, Ky. , Aug. 2, 2017   Marshall County Hospital ... services (ES) team to proactively reduce the risk of hospital-acquired infections (HAIs). The new addition, ... that uses UVC light energy to kill deadly pathogens such as C. diff , ... Tru-D SmartUVC ... Tru-D in action in a patient ...
Breaking Medicine Technology: