Navigation Links
Low Dose of Stem Cells Might Provide Relief to Those Suffering from Arthritis of the Knee
Date:6/13/2016

A new study appearing in STEM CELLS Translational Medicine (SCTM) indicates that a single low dose of a patient’s own stem cells might offer relief from osteoarthritis of the knee.

Osteoarthritis (OA) is the most common chronic condition of the joints, resulting from the cartilage or cushion between the joints breaking down. This leads to pain, stiffness and swelling. OA is on the rise in the western world, in part because of the aging population and also because of obesity, which strains the joints by increasing the load they carry. Any joint in the body may be affected by OA, but it is particularly common in the knee.

There are no current treatments to stop the progressive degeneration of joint tissues in OA, but many researchers wonder if stem cells might offer a solution due to their regenerative capacity. The study appearing in SCTM was aimed at evaluating both the safety and effectiveness of different doses of a type of stem cell called adipose-derived stromal cell (ASC), taken from adults’ fat tissue.

In the phase I clinical trial conducted in France and Germany from April 2012 to December 2013, 18 patients with symptomatic and severe knee OA were treated with a single local injection of their own ASCs. The patients were divided into three groups of six each, with one group receiving a low dose (23,106) of cells, the second group a medium dose (103,106), and the third a high dose (503,106).

After six months of follow-up, no serious adverse events were reported and the treatment appeared to be safe, said lead investigator Christian Jorgensen, M.D., Ph.D., of University Hospital of Montpellier and director of INSERM’s stem cell research unit. “Although this phase I study included a limited number of patients without a placebo arm,” he said, “we were able to show that this innovative treatment was well tolerated in patients with knee OA and it provided encouraging preliminary evidence of efficacy. Interestingly, patients treated with low-dose ASCs significantly improved in pain and function compared with the baseline”

The next step is to conduct larger, controlled long-term studies to confirm the findings. As such, the research team is initiating a placebo-controlled double-blind phase IIb study.

“This study shows yet another promising indication of stem cell therapy and it will be interesting to see the results of the next phase of the research,” said Anthony Atala, M.D., Editor-in-Chief of STEM CELLS Translational Medicine and Director of the Wake Forest Institute for Regenerative Medicine.

###

The full article, “Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: a phase I dose-escalation trial,” can be accessed at http://stemcellstm.alphamedpress.org/content/early/2016/05/22/sctm.2015-0245.abstract.

About STEM CELLS Translational Medicine: STEM CELLS Translational Medicine (SCTM), published by AlphaMed Press, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices.

About AlphaMed Press: Established in 1983, AlphaMed Press with offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, publishes two other internationally renowned peer-reviewed journals: STEM CELLS® (http://www.StemCells.com), celebrating its 34th year, is the world's first journal devoted to this fast paced field of research. The Oncologist® (http://www.TheOncologist.com), also a monthly peer-reviewed publication, entering its 21th year, is devoted to community and hospital-based oncologists and physicians entrusted with cancer patient care. All three journals are premier periodicals with globally recognized editorial boards dedicated to advancing knowledge and education in their focused disciplines.

Read the full story at http://www.prweb.com/releases/2016/06/prweb13479896.htm.


'/>"/>
Source: PRWeb
Copyright©2016 Vocus, Inc.
All rights reserved


Related medicine news :

1. Can Cholesterol Drugs Kill Prostate Cancer Cells? - Dr. David Samadi
2. More than just Stem Cells: Lung Institute Supports Non-Profits to Promote Lung Health
3. The Technology Evaluation Consortium™ Evaluated the Taconic FRG™ KO Technology for Liver Cells as INNOVATOR in its Signature Square™ Prog
4. Follow Up Study Proves Safety and Efficacy of Stem Cells For Back Pain
5. UMD Study: Safe, Inexpensive Chemical Found to Reverse Symptoms of Progeria in Human Cells
6. LabRoots Hosts Beckman Coulter Webinar that Posits Phenotyping Method for Human Innate Lymphoid Cells with Flow Cytometry
7. NewsWatch Featured, Cellstall, a One-Stop Shop for Tech Accessories
8. LabRoots Announces Beckman Coulter's Webinar Discussing Flow Cytometric Analysis of Human T Cells
9. Los Angeles Spine Surgeon Gives Insight into How Stem Cells Can Relieve Back Pain
10. Mount Sinai Researchers Discover New Epigenetic Mechanism in Brain Cells
11. Mesenchymal Stem Cells Market- MSCs Advances and Applications Analysis in New Report at ReportsnReports.com
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... ... ... On May 24, the Congressional Budget Office (CBO) projected that the amended ... would result in 23 million Americans losing their health insurance by 2026 as compared ... Affordable Care Act (ACA). , “It is clear from the CBO analysis that ...
(Date:5/26/2017)... CA (PRWEB) , ... May 26, 2017 , ... Dr. ... is proud to announce a new, informational blog post on insurance options. If a ... checking insurance plans may help save time and money. Visiting an in-network provider for ...
(Date:5/26/2017)... ... May 26, 2017 , ... “Cactus Jack: Against All Odds”: ... many others. “Cactus Jack: Against All Odds” is the creation of published author, ... Hubbard is married to Jack Carlisle’s third child Jane. Walter. Walter and Jane ...
(Date:5/24/2017)... , ... May 24, 2017 , ... Altec ... participation in nVerge 2017 – a one-day technology conference in San Diego, CA. ... solution, which allows users to fully utilize and enhance their Sage ERP solutions by ...
(Date:5/24/2017)... DC (PRWEB) , ... May 24, 2017 , ... ... Center for Global Policy Solutions is vehemently opposed to Donald Trump’s budget, “A ... formula for despair that inspires fear, demonizes the poor, marginalizes underserved populations, undermines ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... , May 5, 2017   Provista , a ... more than 200,000 customers, today announced Jim Cunniff ... wealth of executive and business experience to Provista, including most ... pharmacy in California . He assumed his ... "Jim is a great fit for Provista," says Jody ...
(Date:5/4/2017)... , May 4, 2017  A recent ... Control, Ultraviolet-C light as a means ... SmartUVC,s ability to reduce bioburden on anesthesia workstations. ... reduction on high-touch, complex medical equipment surfaces contaminated ... infections. "This study further validates the ...
(Date:5/4/2017)... WAYNE, Pa. , May 4, 2017 /PRNewswire/ ... made from thermoplastics and other highly-engineered materials, is ... Microextrusion tubing has been developed in recent ... neurovascular interventional therapies and surgical applications. More expensive ... used to produce microextrusion tubing due to their ...
Breaking Medicine Technology: