Navigation Links
Low-Dose Platelet Transfusions Deemed Safe
Date:2/17/2010

Study finds no bleeding risk in practice that could stretch limited supplies,,,,

WEDNESDAY, Feb. 17 (HealthDay News) -- A lower dose of platelets than is commonly used is safe for people who require transfusions of the clot-forming blood cells, a new study shows.

That's good news for people getting chemotherapy or bone marrow transplants because platelets are often in short supply, said Dr. Victor M. Aquino, a member of the research team whose findings are reported in the Feb. 18 issue of the New England Journal of Medicine.

Frequent platelet transfusions -- once or even twice a day -- are needed for such patients because "chemotherapy damages the bone marrow and causes the body not to produce platelets," said Aquino, an associate professor in the pediatric hematology-oncology division at the University of Texas Southwest Medical Center. "They need to be replaced to prevent bleeding."

The study included 1,272 people who had at least one platelet transfusion. They were divided into three groups, depending on the number of platelets in each transfusion. The high-dose group got the usual amount, roughly 10 trillion cells, and the low-dose group got half that number.

The researchers observed no significant difference in the amount of bleeding among the three groups, the report said.

"You can safely transfuse patients with about one-third the dosage of platelets we normally use," Aquino said.

More frequent transfusions were required for the low-dose group, "but you use fewer platelets in the long run," he said.

Another major finding was that it's safe to allow the blood platelet count to go lower than what is now regarded as the danger point, said study author Dr. Sherrill J. Slichter, a professor of medicine at the University of Washington and director of platelet transfusion research at the Puget Sound Blood Center.

Platelet transfusions are commonly given when blood levels drop below 10,000 cells per cubic millimeter of body-surface area. The study found no danger when platelet counts went as low as 5,000 per cubic millimeter. "As long as you have a morning platelet count of at least 5,000 or greater, the risk of bleeding is essentially the same," Slichter said.

The findings will almost certainly change clinical practice, Slichter and Aquino said. "In our patients, we now transfuse at the lower number," Aquino noted.

Reducing platelet usage would have a number of benefits, Slichter said. "It's an expensive product, and if you can use fewer, that is a cost savings for patients, insurers, hospitals and blood centers," she said.

Platelet supplies must be renewed constantly because they don't last long outside the body, she said. "They have a half-life of five days," Slichter said. "The half-life of red cells is 43 days."

Publication of the study results "hopefully will change transfusion practice," she said.

"In the dose range we used, there was absolutely no effect of dose on the risk of bleeding," Slichter said. "Smaller doses are as hemostatically effective as larger doses."

"This is very good news," said Dr. Donna L. Skerrett, director of transfusion medicine and cellular therapy at New York-Presbyterian/Weill Cornell Medical Center in New York City. "It answers a question that has been asked for quite a while: whether platelet dosage really matters."

Because of the short half-life of platelets, supplies often drop during weekends and because of storms or even holidays, Skerrett said. "It is extremely valuable to know that dosage can be reduced at those times with no harm to patients," she said.

More information

The American Red Cross has more on platelet donation.



SOURCES: Victor M. Aquino, M.D., associate professor, pediatric hematology-oncology, University of Texas Southwest Medical Center, Dallas; Sherrill J. Slichter, M.D., professor, medicine, University of Waashington, and director, platelet transfusion research, Puget Sound Blood Center, both in Seattle; Donna Skerrett, M.D., director, transfusion medicine and cellular therapy, New York-Presbyterian/Weill Cornell Medical Center, New York City; Feb. 18, 2010, New England Journal of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. AUDIO from Medialink and Bayer: Lifesaving Benefits of Low-Dose Aspirin Therapy Maintained with Naproxen Sodium
2. Low-dose aspirin does not appear to reduce risk of CV events in patients with diabetes
3. Type 2 Diabetics Studied in Low-Dose Aspirin Trial
4. FDA Approves Low-dose Regimen of PREMARIN Vaginal Cream to Treat Moderate to Severe Postmenopausal Dyspareunia - Painful Sexual Intercourse
5. FDA Approves Low-dose Regimen of PREMARIN Vaginal Cream to Treat Moderate to Severe Postmenopausal Dyspareunia – Painful Sexual Intercourse : Agency Grants New Indication for Bothersome Vaginal Symptom Associated with Menopause
6. What is the most effective therapy for low-dose aspirin induced peptic ulcer?
7. Low-Dose Acitretin May Reduce Nail Psoriasis
8. Drug Limits Stomach Trouble in Patients Taking Low-Dose Aspirin
9. Study Evaluating Efficacy and Safety of Two Low-dose Regimens of PREMARIN Vaginal Cream for the Treatment of Moderate to Severe Vaginal Atrophy Now Published
10. NIH takes step to assess any possible risk associated with low-dose radiation exposure
11. New EPA Rodent Study Finds No Low-Dose BPA Effects on Reproductive Function or Behavior
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... ... readers, this installment is bolstered by inspiring human-interest stories, courtesy of awareness-driven celebrities ... within the industry, from leading advocates, associations and industry leaders such as Bioness. ...
(Date:5/27/2016)... ... 2016 , ... Each year Standard Process Inc. ... this year’s Life University winner of a $2,500 scholarship from Standard ... Awards ceremony. , Outerbridge is approaching her last quarter at Life University in ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cabot Corporation, Pfizer, and 3M ... to court documents and SEC filings. A jury has returned a verdict ... Optical Corporation, Case No. BC588866, Los Angeles County, California. The jury awarded $22.8 ...
(Date:5/26/2016)... ... 2016 , ... The Woodlands at John Knox Village , Florida’s first ... for living and healing, celebrated its grand opening, today. The Woodlands at John Knox ... by Empowered Staff. , “This is an incredibly fulfilling time for John Knox Village ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... Retinal Degeneration” for the Foundation Fighting Blindness, Long Island Chapter on June 4, ... the public. , Dr. Maisel, founder of Retina Group of New York ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 25, 2016  Granger Diagnostics today announced immediate availability ... and infections. This test ensures discovery of ALL ... The test requires only a simple swab of the ... David G. Bostwick , MD, Chief Medical Officer, ... healing: "We are excited to make available, for ...
(Date:5/25/2016)... , May 25, 2016 ... the precision of circulating tumour DNA (ctDNA) analysis ... the appointment of Professor Clive Morris ... leadership across the clinical development programme, scientific collaborations, ... help deliver significant improvements in clinical outcomes for ...
(Date:5/24/2016)... 2016 Cirujanos holandeses han puesto ... los médicos a compartir sus mejores prácticas por el ... Profesionales médicos de Europa, África, Asia ... la aplicación, que combina la transmisión en vivo con ... Educación   "Imagine un médico de ...
Breaking Medicine Technology: