Navigation Links
Low-Dose Aspirin May Reduce Colon Cancer Risk
Date:9/16/2010

By Jenifer Goodwin
HealthDay Reporter

THURSDAY, Sept. 16 (HealthDay News) -- Taking low-dose aspirin daily may reduce the risk of colorectal cancer, new research finds.

Prior research has shown higher doses of aspirin reduces the risk of colon cancer. But this study is among the first to show that lower doses -- which have less risk of side effects such as gastrointestinal bleeding -- may also be effective, said Eric Jacobs, strategic director of pharmacoepidemiology for the American Cancer Society.

For this study, researchers in Scotland asked 2,279 people with colorectal cancer and 2,907 people without colorectal cancer to answer questions about diet and lifestyle choices could affect cancer risk.

Participants were asked how often they took low-dose aspirin (75 milligrams), as well as non-aspirin NSAIDs (non-steroidal anti-inflammatory drugs) such as naproxen (Aleve, Naprosyn and others) and ibuprofen (Advil, Motrin and others) in the year prior to their cancer diagnosis or recruitment in the study.

About 18.1 percent of those without cancer reported taking aspirin during that time, compared to 15.5 percent of those who had colorectal cancer.

Participants who reported taking low-dose aspirin regularly for a year or more were about 22 percent less likely to have colorectal cancer. The reduction was clinically significant among those who reported taking low-dose aspirin for more than five years, according to the study: They were 30 percent less likely to develop cancer than their peers who didn't take the painkillers.

Although the greatest risk reduction occurred in those consuming more than 525 milligrams of aspirin a week, the protective effect was present even for the lowest daily dose.

"The new case-control study from Scotland is one of the largest to date to have specifically examined low dose aspirin, and provides some evidence that using low-dose aspirin for five or more years may also reduce colorectal cancer risk," said Jacobs, who was not involved in the research. "However, previous studies of low-dose aspirin and colorectal cancer have had mixed results, and results of this study need to be confirmed."

The study also found that taking any NSAID regularly was associated with a reduced risk of colorectal cancer, compared to those who didn't use the painkillers.

The subjects and controls had been matched for age, gender and locale as well as smoking, alcohol and fiber intake, and the findings held true even after results were adjusted for weight, body-mass index and other factors, according to the study, which was published in the current issue of the journal Gut.

However, taking NSAIDs of any type before diagnosis did not increase survival time in bowel cancer patients or influence the risk of death from any cause, researchers noted.

Previous epidemiological studies suggest higher doses of aspirin (325 miligrams daily, or a standard adult-strength aspirin) and other NSAIDs reduce risk of colorectal cancer, said Dr. Andrew Chan, an assistant professor of medicine at Harvard Medical School and attending gastroenterologist as Massachusetts General Hospital.

While the new findings are promising, since many Americans are already taking aspirin for cardiovascular disease, more research is needed before saying with certainty that low-dose aspirin is also effective, Chan said.

Because the study is retrospective, for example, it relies on people's recollections of aspirin use, which may not be accurate. The researchers also noted it was unknown whether the subjects with colorectal cancer continued to take NSAIDs after diagnosis, "which may clearly limit the conclusions drawn from the survival data presented."

"What is very well-established in the literature, based on prior studies and now this study, is that aspirin is clearly effective in reducing the risk of colorectal cancer," Chan said. "What is less clear and still remains somewhat controversial is what is the minimum effective dose in terms of prevention."

Because aspirin can have potentially harmful side effects, organizations such as the American Cancer Society don't recommend taking aspirin to ward off colorectal cancer.

"Decisions about whether to take aspirin should be made together with a physician and should be based on balancing the heart disease prevention benefits against the risks of side effects," Jacobs said.

Worldwide, colorectal cancer ranks second as a cause of cancer deaths, killing nearly half a million people a year, according to background information in the study.

Jacobs also stressed the adults should continue to get screened for colorectal cancer. "Colorectal screening tests can result in the detection and removal of colorectal polyps before they ever turn into cancer. The American Cancer Society strongly recommends all men and women 50 or older get a colorectal cancer screening test."

More information

The American Cancer Society has more on colorectal cancer.

SOURCES: Eric Jacobs, Ph.D., strategic director, pharmacoepidemiology, American Cancer Society, Atlanta; Andrew Chan, M.D. assistant professor, medicine, Harvard Medical School, and attending gastroenterologist, Massachusetts General Hospital, Boston; 2010 Gut


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Low-Dose Omega-3 Fatty Acids Dont Protect Heart Patients
2. Low-Dose HRT Patch May Lessen Stroke Risk
3. Low-Dose Platelet Transfusions Deemed Safe
4. Can aspirin prolong a healthy life?
5. Aspirin recommendations changed for many younger diabetic patients
6. Experts Advise At-Risk Diabetics to Begin Daily Aspirin Later
7. Aspirin May Increase Risk of Crohns Disease
8. Aspirin Alone Works Best to Prevent Clots a Year After Stenting
9. Cardiologists Comment on Aspirin Versus Resveratrol
10. Aspirin May Boost Breast Cancer Survival
11. Successful periodontal therapy may reduce the risk of preterm birth, according to Penn dental study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Low-Dose Aspirin May Reduce Colon Cancer Risk
(Date:5/27/2016)... ... ... More than a third of American adults are considered obese, says the ... increased attention in recent years, as an article published May 18th on ... people are familiar with the basic requirements of maintaining a healthy diet and exercise ...
(Date:5/27/2016)... ... 27, 2016 , ... W.S. Badger Co. Inc ., the maker of ... recognized as one of the best small businesses for new dads by Fatherly, the ... small businesses providing progressive benefits to new parents on the organization’s 2016 Best ...
(Date:5/27/2016)... NY (PRWEB) , ... May 27, 2016 , ... This ... of a stroke, which we as a society can control and change. , As ... occurs nearly every 40 seconds within the United States. Plus, with an estimated 129,000 ...
(Date:5/27/2016)... ... 27, 2016 , ... Beleza Medspa has initiated a new program ... is the first time that Coolsculpting is being used for for more than just ... ensure they meet the prescribed body-fat standard, measured by the circumference-based tape method. ...
(Date:5/27/2016)... , ... May 27, 2016 , ... ... scholarships to students studying complementary medicine. Allison Outerbridge is this year’s Life ... award on May 18 at the university’s Student Leadership Awards ceremony. , Outerbridge ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... und GERMANTOWN, Maryland , May ... mit Therawis bedient dringenden ... QIAGEN N.V. (NASDAQ: QGEN ... eine Lizenz- und Entwicklungsvereinbarung mit Therawis Diagnostics GmbH ... Onkologie eingegangen zu sein. Ein erstes Projekt wird ...
(Date:5/25/2016)... SPRINGS, Florida , May 25, 2016 ... Business Conference & Expo earlier this month, the numbers ... As revenues continue to climb into the billions, more ... the newly released 4th Edition State of Legal Marijuana ... Frontier, a cannabis-focused data-analysis firm, much of the increase ...
(Date:5/25/2016)... PUNE, India , May 25, 2016 /PRNewswire/ ... Pipeline Review, H1 2016"market research report that provides ... complete with comparative analysis at various stages, therapeutics ... route of administration (RoA) and molecule type, along ... releases. It also reviews key players involved in ...
Breaking Medicine Technology: