Navigation Links
'Love handles' melt away at the push of a button
Date:4/23/2013

Micro-RNA 155 was silent

The researchers at Bonn University and their colleagues from the Federal Institute of Drugs and Medical Devices (BfArM) and from the University of Regensburg worked with so-called transgenic and knockout mice in whom the gene for micro-RNA 155 was either increased or silenced. "The mechanism was already set in motion when the micro-RNA 155 was only halved in the mice," reports lead author Yong Chen, graduate student of the NRW International Graduate School BIOTECH-PHARMA. The mice then had significantly more brown fat cells available than did the control gro up - and had even converted white fat cells into brown fat cells.

Clues to the causes of lipid metabolism diseases

The micro-RNA functions as an antagonist to the brown fat cells. "As long as enough micro-RNA 155 is present, the production of brown fat cells is blocked," says Chen. Only if it falls below a certain proportion does this brake let up; the blueprint for brown fat can be read and implemented by the cell - the desired fat burners can develop. These findings help scientists better understand the causes of lipid metabolism diseases.

Hope for new therapies against obesity

The scientists at the University of Bonn see in their results a potential starting point for drugs to combat obesity. The researchers have clues to the fact that the results, if anything, can be transferred from mice to humans. Thus, for example, researchers in Leipzig found increased levels of micro-RNA 155 in significantly overweight patients. This corresponds to findings from animal models: A lot of micro-RNA 155 is associated with reduced fat burning. "However, we are still in the basic research stage," says Prof. Pfeifer. The path to suitable drugs is still a long one.


'/>"/>

Contact: Dr. Alexander Pfeifer
alexander.pfeifer@uni-bonn.de
49-228-287-51300
University of Bonn
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Nails Need Love, Too
2. Battle for Grace: A Memoir of Pain, Redemption and Impossible Love
3. Fantasy Lover Formula: Review Examining System To Become "Her Fantasy Lover" Released
4. Lung Cancer Asbestos Victims Center Now Urges Families Of A Retired Factory Worker To Call Them If Their Loved One Has Lung Cancer And Was Exposed To Asbestos At Work
5. Audiences in Beijing Packed Auditoriums to See a Love Documentary - Real Story of an Unorthodox Matchmaker
6. Love, Men, and Money, a Humorous Self-help Book on Relationships for Women, is Now Available on Kindle
7. Lung Cancer Asbestos Victims Center Now Urges Families of Nonsmoker Lung Cancer Victims To Call Them If Their Loved One Was Exposed To Asbestos In Their Workplace
8. Targeted Equine Nutrition Launches New Website For Horse Lovers
9. Jacent M Mpalyenkana, has Published a Humorous Self-Help Book on Relationships for Women Titled, Love, Men, and Money
10. Lung Cancer Asbestos Victims Center Now Urges Families To Help Them Identify A Nonsmoker Loved One Who Had Exposure To Asbestos In The Workplace And Now Has Lung Cancer
11. Norah Guide Offers Post Valentine Zodiac Love Blueprint – Premium Astrology Love Guide
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... ... August 31, 2015 , ... MeYou Health ®, a social well-being company ... app, Walkadoo , by including an in-app step tracker. , Walkadoo is a ... walking habits. Rather than broadly assign every Walkadoo member 10,000 steps a day (as ...
(Date:8/31/2015)... ... August 31, 2015 , ... The ... the use of health IT to create efficiencies in healthcare information exchange, announces ... . Taking place at the Hyatt Regency Reston in Reston, Va. from October ...
(Date:8/31/2015)... ... August 31, 2015 , ... It’s a lot like ... director of GreenFields of Geneva. During his first days on the job, he’s run ... nice seeing them, and I like knowing that they’re living in such a wonderful ...
(Date:8/31/2015)... ... August 31, 2015 , ... The ... Talent Management Division , a department devoted to helping organizations identify and keep ... goes beyond selection, and The Brooks Group believes in offering a solution that ...
(Date:8/31/2015)... , ... August 31, 2015 , ... ... Commerce Exchange and Organization Supporting Business Owners and provided a tour of their ... Georgia, represents the success possible to international companies expanding business in the U.S. ...
Breaking Medicine News(10 mins):Health News:Walkadoo™ Walking Program Now Includes In-app Step Tracker 2Health News:WEDI Announces Program for Annual Fall Conference: WEDI-Con 2015 2Health News:WEDI Announces Program for Annual Fall Conference: WEDI-Con 2015 3Health News:Friendship Senior Options Welcomes New Executive Director for GreenFields of Geneva 2Health News:The Brooks Group Introduces Talent Management Division 2Health News:The Brooks Group Introduces Talent Management Division 3Health News:PartnerTech Supports Economic Growth as Host 2
... HealthDay Reporter , TUESDAY, Oct. 25 (HealthDay News) ... cantaloupes produced at a Colorado farm has reached 28, with ... late Tuesday. Officials said last week that the outbreak ... farm. Inspections on Sept. 22 and 23 ...
... potential leukemia therapy targets only cancer cells, while leaving ... cancer cells and healthy cells, causing significant side effects, ... This research is being presented at the 2011 ... Exposition in Washington, D.C., Oct. 23 27. ...
... both men and women, yet men remain underrepresented in research. A ... has found that the medical impact of the disorder is ... research has shown that the number of men seeking treatment is ... is closely linked to obesity and excessive weight gain as well ...
... high proportion of dense breast tissue, as seen with a ... But the role of non-dense fat tissue in the breast ... access journal Breast Cancer Research separates the breast ... shows that large areas of either are independently associated with ...
... TUESDAY, Oct. 25 (HealthDay News) -- Men with a history ... for lung cancer could benefit from a simultaneous check for ... estimated that smoking will cause more than 8 million deaths ... addition to cardiovascular disease and cancer, COPD is a major ...
... activity and cancer prevention, treatment recovery and survivorship have ... component in the treatment of a disease that claims ... to the American Cancer Society,s Global Facts and Figures. ... and Cancer, Dr. Kerry Courneya, is one of the ...
Cached Medicine News:Health News:Death Toll From Listeria Outbreak Hits 28 2Health News:Death Toll From Listeria Outbreak Hits 28 3Health News:Study shows why underrepresented men should be included in binge eating research 2Health News:CT Scans May Pick Up COPD Early in Smokers 2Health News:CT Scans May Pick Up COPD Early in Smokers 3Health News:Canada Research Chair renewal for Kerry Courneya 2Health News:Canada Research Chair renewal for Kerry Courneya 3
(Date:8/31/2015)... -- Regen BioPharma, Inc. (OTCBB: RGBP) and (PINK: ... of delivering its patented (US Patent 8,263,571) gene ... a clinically approved formulation as delivery system.  The ... silencing therapeutics in which the gene silencing drug ... By utilizing a local delivery system, potential toxicities ...
(Date:8/31/2015)... , Aug. 31, 2015  Soligenix, ... late-stage biopharmaceutical company developing products that address unmet ... and biodefense, announced today it has completed enrollment ... Data Review Committee (DRC) earlier this year, into ... is a first-in-class innate defense regulator (IDR) and ...
(Date:8/31/2015)... , Aug. 31, 2015  QT Vascular Ltd., together with ... together with its subsidiaries, the "Group"), a global ... of advanced therapeutic solutions for the minimally invasive ... results of the below-the-knee ("BTK") cohort of patients ... were presented on August 15, 2015 at the ...
Breaking Medicine Technology:Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 2Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 3Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 2Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 3Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 4Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 5Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 6Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 2Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 3Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 4
... levels were significantly higher in patients with osteosarcoma than ... Biological Trace Element Research (April 2009). Osteosarcoma, ... young adults.Randhu and colleagues measured serum fluoride levels in ... one had osteosarcoma, group two had non-osteosarcoma bone tumors, ...
... U.S. Agency for International Development (USAID) is convening a ... Ethiopia, in a regional exercise that will kick off ... The three-day exercise seeks to advance global capacity ... a pandemic. As recently emphasized by outbreaks of swine ...
Cached Medicine Technology:Another Study Links Fluoride to Bone Cancer 2USAID Cooperates in Pandemic Preparedness Initiative 2USAID Cooperates in Pandemic Preparedness Initiative 3
The Genesis Camera meets the needs of those with specific requirements that cannot be met by a conventional 'chinrest' type camera....
Eye Q PRO is the optimum choice for ophthalmologists and clinicians specializing in advanced pathology and research....
Auto Lensmeter LM-970...
... designed to eliminate the subjective nature of ... providing repeatable, objective measurements every time. The ... icon-based operating system ensure fast and simple ... optimal lens positioning and, in auto mode, ...
Medicine Products: