Navigation Links
Louisiana State University Health Sciences Center research discovers key to survival of brain cells
Date:9/28/2011

New Orleans, LA -- Nicolas G. Bazan, MD, Ph.D, Boyd Professor and Director of the Neuroscience Center of Excellence at LSU Health Sciences Center New Orleans, and David Stark, an MD/Ph.D student working in his lab, have discovered how a key chemical neurotransmitter that interacts with two receptors in the brain promotes either normal function or a disease process -- determining whether brain cells live or die. The work is published and highlighted in the September 28, 2011 issue of the Journal of Neuroscience.

These findings reveal how receptor signaling takes place between receptors of synapses (gaps between neurons through which chemical or electrical signals pass permitting cells to "talk" to each other) and the mechanisms involved in initiating disease. The receptors, called NMDARs, are located both inside and outside of the synapses. Activation of the NMDRs inside (synaptic) allows the synapse to adjust response to signals and activation of the synaptic NMDRs is also required for survival of the cell. In contrast, activation of the receptors outside the synapse (extrasynaptic) leads to cell death.

The LSUHSC research team believed that activation of the extrasynaptic NMDRs promotes the pathological effects of cyclooxygenase 2 (COX-2), a protein known to contribute to inflammation associated with neurotoxicity. They found that activating the synaptic NMDRs greatly increased levels of COX-2, but not of the chemical (arachidonic acid) upon which COX-2 acts. Conversely, activating the extrasynaptic NMDRs increased the levels of arachidonic acid, but not COX-2. The researchers discovered, however, when synaptic and extrasynaptic NMDARs were sequentially activated, the levels of both COX-2 and arachidonic acid increased, as did neurotoxic inflammation.

"We have discovered a fascinating relationship regarding the "conversations" that occur between these two receptors in the brain," said Dr. Nicolas G. Bazan, Professor and Director, LSUHSC
'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Louisiana State University Health Sciences Center research shows fish oil component given up to 5 hours after stroke limits brain damage
2. Louisiana Tech kinesiology professor receives national editorial excellence award
3. Louisiana's First DNP Program Kicks Off Classes at Loyola University New Orleans
4. Louisiana Tech students, faculty earn accolades from Louisiana Dietetic Association
5. Louisiana Law Firm Neblett, Beard & Arsenault Launches New Foodborne Illness Site
6. New, National Amnesty International Report Finds Appalling U.S. Death Rate for Women Having Babies, Systemic Failures and Shocking Disparities in Maternal Health Care System; Louisiana is 46th Among All States in Maternal Mortality
7. Pew Report: Louisiana Failing to Address Childrens Dental Health Crisis
8. SHARECOR Partners With Quantros, Inc. to Facilitate Core Measures and Regulatory Reporting in Louisiana Hospitals
9. Gene may be good target for tough-to-kill prostate cancer cells
10. New UC research promises better collection of prostate cancer cells
11. Saw Palmetto Doesnt Help Enlarged Prostate: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... (PRWEB) , ... August 01, 2015 , ... The condition ... among both men and women often causing pain and discomfort. Those who spend a ... circulatory problem, and Northeast Houston Vein Center is doing what it can to create ...
(Date:8/1/2015)... ... 2015 , ... Tina Wilcoxson, owner of Freeport Maine’s Royal River Natural Foods, ... the National Retail Federation, the largest retail trade association in the world, for her ... owners to be named as such. According to the NRF’s website, Retail Champions are ...
(Date:8/1/2015)... ... August 01, 2015 , ... Professional Orthopedic and Sports ... acquired Premier Physical Therapy & Wellness (“Premier”) — with 13 locations in Manhattan, ... “Our acquisition of Premier Physical Therapy & Wellness solidifies Professional as the largest ...
(Date:8/1/2015)... (PRWEB) , ... August 01, 2015 , ... Lume Wellness ... that is free to download on the Apple AppStore. , The app is ... even mood, thus acting as a tool to view personal health and use this ...
(Date:8/1/2015)... ... ... “ reTXT ” was featured on NewsWatch as part of its monthly AppWatch, which ... Android, and Windows. Joe Toohey, the host of AppWatch and technology expert, conducted the ... message including ones already sent. , While text messaging has more features than it ...
Breaking Medicine News(10 mins):Health News:Northeast Houston Vein Center Warns Men about Varicose Veins 2Health News:Northeast Houston Vein Center Warns Men about Varicose Veins 3Health News:Local Retail Advocate Wins National Recognition 2Health News:Professional Physical Therapy Now Largest Outpatient Physical Therapy Provider in Northeast With Acquisition of Premier Physical Therapy & Wellness 2Health News:Lume Wellness Launches Health and Fitness Tracker iPhone App 2Health News:Correct Auto-Correct and Clarify the Unclear with reTXT Messaging App 2
... A new evaluation tool can predict the mortality risk in ... // of a recent study. According to researchers the new ... treatment of acute heart failure and offers a simple, quick ... and quickly decide on a treatment strategy. ,Researchers used ...
... Norwegian University of Science and Technology, has managed to spark ... small study done using driving simulators to test the reaction ... dyslexic) by the University found that Dyslexic drivers took 30% ... at the Norwegian University based in Trondheim, asked the volunteers ...
... phobia may increase ones likelihood of developing fatal heart ... is true for women with phobic anxieties including the ... ,Studies in the past have suggested psychosocial factors such ... an increased risk of fatal heart disease. Studies in ...
... say combining a 6 percent salicylic acid gel with ... for plaque psoriasis, an inflammatory skin condition characterized by ... study 30 adults with plaque-type psoriasis were observed for ... acid gel plus 0.1 percent tacrolimus ointment or 6 ...
... in reducing the risk of death following a heart attack ... find researchers according to latest research. ,In a study ... the composite outcome of death, heart attack, and stroke at ... from 11 percent of patients in the placebo group to ...
... coupled with a long-acting beta2-agonist (formoterol) can actually provide ... on high doses of inhaled steroid, say researchers according ... effects of various combinations of medicine on asthma symptoms ... countries were analyzed. The patients were divided into three ...
Cached Medicine News:Health News:Understanding The Link Between Phobias And Fatal Heart Disease 2
(Date:7/31/2015)... -- According to a new market research ... (BIA), Dual-Energy X-ray Absorptiometry (DEXA), Skinfold Calipers, Air Displacement ... Forecast to 2019", published by MarketsandMarkets, the global Body ... and is estimated to grow to $1,425.7 Million by ... to 2019. Browse 41 market data ...
(Date:7/30/2015)... , July 30, 2015 IRIDEX Corporation (NASDAQ: ... its second quarter 2015 financial results after the market ... conjunction with the release, the Company will host a ... p.m. Eastern Time on Thursday, August 6, ... and other business developments. Interested parties may ...
(Date:7/30/2015)... , July 30, 2015  Unichem Pharmaceuticals ( ... lot of Hydrochlorothiazide tablets 25 mg 1000-count bottle to ... a precautionary measure due to the identification of a ... The risk associated with mistakenly taking ... the increased probability of experiencing Clopidogrel,s side effects which ...
Breaking Medicine Technology:Body Composition Analyzers Market Worth $1,425.7 Million by 2019 2Body Composition Analyzers Market Worth $1,425.7 Million by 2019 3Body Composition Analyzers Market Worth $1,425.7 Million by 2019 4IRIDEX Announces Second Quarter 2015 Conference Call and Release Date 2Unichem Pharmaceuticals (USA), Inc. Issues a Voluntary Nationwide Recall of Hydrochlorothiazide Tablets Due to the Potential Presence of Foreign Tablets 2
... /PRNewswire-Asia/ -- Bristol-Myers Squibb Company (NYSE: ... (NYSE: SCR ), a leading pharmaceutical company ... the strategic partnership formed last year to include a ... agreed to co-develop BMS-795311, Bristol-Myers Squibb,s preclinical small molecule ...
... SAN DIEGO, Dec. 13, 2011  BioMed Realty Trust, Inc. ... has entered into a definitive agreement to acquire Prudential ... Street properties.  BioMed previously acquired a 20% interest in ... venture entered into between BioMed and PREI.  The Rogers ...
Cached Medicine Technology:Simcere and Bristol-Myers Squibb Enter Innovative Partnership to Develop Cardiovascular Compound 2Simcere and Bristol-Myers Squibb Enter Innovative Partnership to Develop Cardiovascular Compound 3Simcere and Bristol-Myers Squibb Enter Innovative Partnership to Develop Cardiovascular Compound 4Biomed Realty Trust to Acquire Remaining 80% Interest in Rogers Street Properties in Cambridge, Massachusetts for $308 Million - Increasing Ownership to 100% 2Biomed Realty Trust to Acquire Remaining 80% Interest in Rogers Street Properties in Cambridge, Massachusetts for $308 Million - Increasing Ownership to 100% 3Biomed Realty Trust to Acquire Remaining 80% Interest in Rogers Street Properties in Cambridge, Massachusetts for $308 Million - Increasing Ownership to 100% 4
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: