Navigation Links
Loss of weight associated with chronic illness may soon have first treatment
Date:11/15/2011

PORTLAND, Ore. Patients with cancer, heart disease and other chronic illness struggle not only with complications inherent to their disease, they also experience an involuntary loss of weight and muscle mass triggered by the body's natural response to infection and inflammation. Increasing nutrition intake does not mitigate the process and there is no treatment.

Today scientists at Oregon Health & Science University Doernbecher Children's Hospital report they have discovered a definitive role for the brain in regulating loss of muscle mass that previously has not been described. The process is driven by a signaling system in the brain that controls stress responses and the release of the stress hormone cortisol. This finding is of particular significance because many drugs that regulate the release of cortisol are now in development for the treatment of other conditions.

"The wasting associated with chronic illness has been recognized since the time of the ancient Greeks. Despite this long history, no effective treatments currently are available that can reverse muscle wasting," said Daniel L. Marks, M.D., Ph.D., principal investigator and associate professor of pediatrics in the Pap Family Pediatric Research Institute at OHSU Doernbecher Children's Hospital.

"Not only does wasting negatively affect quality of life, but it also significantly impacts mortality in patients with chronic illness. Our lab has found that the system by which our brains mediate the response to stressful stimuli is critical in regulating the loss of muscle mass that accompanies disease," Marks said.

In response to infection, the body mobilizes protein stored in the muscle to fuel the immune system. This process is critical in the response to acute infection, but when it occurs excessively, as in the case of chronic disease, profound loss of muscle mass and weakness result.

Theodore Braun, a Ph.D. candidate in the Marks lab, and colleagues found that the muscle of rodents with isolated inflammation in the brain undergoes rapid atrophy. This process, they discovered, leads to the rapid release of cortisol into the blood, which acts on muscle to elicit wasting. When this system is blocked, the muscle mass loss in response to inflammation is prevented. Furthermore, when cortisol was infused at a level mimicking the production that occurs in many chronic diseases, dramatic muscle wasting results.

Because the prevention of muscle mass loss in response to cancer growth recently has been shown to improve survival in mice, the researchers suggest that targeting this system could improve quality of life and reduce mortality associated with chronic disease.

The study, "Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis," was funded by the Canadian Institutes of Health Research and the National Institutes of Health and is published in today's The Journal of Experimental Medicine.


'/>"/>

Contact: Tamara Hargens-Bradley
hargenst@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert  

Related medicine news :

1. Primary care-based weight intervention helps obese patients reduce weight
2. Prenatal exposure to environmental pollutants determines weight and size at birth
3. Obese monkeys lose weight on drug that attacks blood supply of fat cells
4. Dairy foods may improve bone health during diet and exercise in overweight premenopausal women
5. Knee Arthritis Striking at Younger Ages, But Weight Loss May Help
6. Fast-Food Outlets Nearby Might Not Cause Weight Gain
7. Body weight, sleep-disordered breathing and cognition linked in children
8. Weighing Weight-Loss Programs
9. Overweight Teens Dont Seem to Grasp Weight Loss Rules
10. Study finds overweight teens want to lose weight, going about it the wrong way
11. Obese people regain weight after dieting due to hormones
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Loss of weight associated with chronic illness may soon have first treatment
(Date:4/29/2016)... ... , ... The number of chronically and seriously ill individuals is growing. Americans ... urgent need for highly skilled care managers and care coordinators. Care Excellence ... and retain care managers, and enhance their skills. , Care Excellence helps ...
(Date:4/28/2016)... ... , ... Sublime Beauty® is offering a special deal on its webstore. , Buy 1 product ... applied to the product with lesser value. In addition, a free bonus of 3 ... in products. , "So many women (men, too) love our products and get good results. ...
(Date:4/28/2016)... ... 28, 2016 , ... La Sirena Foods provides premium canned seafood, specifically, Tuna, ... looking to grow their market share in the USA. , "We are happy to ... Sirena Foods and indirectly with Otis McAllister , a leading global food ...
(Date:4/28/2016)... ... April 28, 2016 , ... The ... a new CDISC standard, Clinical Trial Registry (CTR) XML. Clinical trial registries ... will make it possible to build applications that generate submissions for multiple, ...
(Date:4/28/2016)... ... April 28, 2016 , ... Greener Hydroponics is now offering ... are frequently used by professional organic farmers and nurseries according to Sales Manager Joe ... of fabric pots. Our goal is to offer wholesale level pricing and ultra-fast shipping ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... April 29, 2016 Glycotope GmbH, ... today announces the appointment of Dr. Alfredo Zurlo ... is an oncologist with many years clinical experience and ... industries. His last role was at Mologen AG where ... Executive Board. Previously Dr. Zurlo held various positions at ...
(Date:4/28/2016)... FLINT, Mich. , April 28, 2016 /PRNewswire/ ... transaction . Diplomat Pharmacy, Inc. (NYSE: DPLO), the ... it has signed a definitive agreement to acquire ... Advanced Specialty Pharmacy ("TNH"), a leading specialty pharmacy ... Van Nuys, California . In 2015, ...
(Date:4/28/2016)... 28, 2016 Research and Markets ... Surgery Products Market 2016-2020" report to their offering. ... The global plastic surgery products market is ... the period 2016-2020. , ,The growing adoption of laser ... growth of the market. Lasers are used to treat ...
Breaking Medicine Technology: