Navigation Links
Loss of sleep, even for a single night, increases inflammation in the body
Date:9/2/2008

Philadelphia, PA, September 2, 2008 Loss of sleep, even for a few short hours during the night, can prompt one's immune system to turn against healthy tissue and organs. A new article in the September 15th issue of Biological Psychiatry, by the UCLA Cousins Center research team, reports that losing sleep for even part of one night can trigger the key cellular pathway that produces tissue-damaging inflammation. The findings suggest a good night's sleep can ease the risk of both heart disease and autoimmune disorders such as rheumatoid arthritis.

Specifically, the researchers measured the levels of nuclear factor (NF)-?B, a transcription factor that serves a vital role in the body's inflammatory signaling, in healthy adults. These measurements were repeatedly assessed, including in the morning after baseline (or normal) sleep, after partial sleep deprivation (where the volunteers were awake from 11 pm to 3:00 am), and after recovery sleep. In the morning after sleep loss, they discovered that activation of NF-?B signaling was significantly greater than after baseline or recovery sleep. It's important to note that they found this increase in inflammatory response in only the female subjects.

These data close an important gap in understanding the cellular mechanisms by which sleep loss enhances inflammatory biology in humans, with implications for understanding the association between sleep disturbance and risk of a wide spectrum of medical conditions including cardiovascular disease, arthritis, diabetes, certain cancers, and obesity. John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, comments: "The closer that we look at sleep, the more that we learn about the benefits of sleeping. In this case, Irwin and colleagues provide evidence that sleep deprivation is associated with enhancement of pro-inflammatory processes in the body."

"Physical and psychological stress brought on in part by grinding work, school and social schedules is keeping millions of Americans up at night," said Dr. Irwin, lead author and director of the Cousins Center for Psychoneuroimmunology at the Semel Institute. "America's sleep habits are simply not healthy. Our findings suggest even modest sleep loss may play a role in common disorders that affect sweeping segments of the population." In other words, sleep is vitally important to maintaining a healthy body. And as Dr. Krystal notes, "these findings provide a potential mechanistic avenue through which addressing sleep disturbance might improve health."


'/>"/>

Contact: Jayne Dawkins
ja.dawkins@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

Related medicine news :

1. Findings on bladder-brain link may point to better treatments for problems in sleep, attention
2. Sleep, baby, sleep: parents behavior has direct impact on children’s slumber
3. Calif. Nurses Laud Passage of Single-Payer, SB 840, Seen as National Model for Guaranteed Healthcare for All
4. Just Stand Up Star-Studded Charitable Single Sets Pace for Stand Up To Cancer Fundraising Campaign
5. Gladstone scientists identify single microRNA that controls blood vessel development
6. Single-Pill Combinations Diovan HCT and Exforge Approved in US as First-Line Treatments for High Blood Pressure
7. Being Single in Midlife Could Raise Risk for Dementia Later
8. Consumer and Healthcare Groups Call for Clear, Concise Single Document From Pharmacy
9. Combined Insurance Reports that Single Working Women's Week is a Good Time for Annual Review of Insurance Coverage
10. Single-nucleotide polymorphisms do not substantially improve risk prediction for breast cancer
11. Parents of twins report more mental health symptoms than parents of singletons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2017)... ... September 20, 2017 , ... ... of the Best Places to Work in the Research Triangle for 2017. , ... nominated, a company had to meet a threshold in employee participation--a percentage that ...
(Date:9/20/2017)... ... 2017 , ... Demand generation pioneer True Influence has announced ... The Marketing Tech Conference October 2–4, at the Hynes Convention Center in Boston, ... representing such thought-leading companies as JP Morgan Chase, GE Digital, and Dun & ...
(Date:9/20/2017)... ... ... In just a short time since going on sale on Wal-Mart Stores-owned ... trying the product for the first time, and others who had already been using ... Moore, MD, for everyone from athletes at risk from multiple concussions to elderly consumers ...
(Date:9/20/2017)... ... September 20, 2017 , ... Health & Safety Institute (HSI) ... HAZWOPER 8-, 24- and 40-Hour courses from now until November 30, 2017 to assist ... offering these discounted prices to all businesses and government agencies – whether or not ...
(Date:9/20/2017)... ... September 20, 2017 , ... Houston, Texas, investment firm ... Friday, September 8, and Monday, September 11, off work and rolled up their sleeves ... before heading to local homes to start the process of rebuilding. , CORDA founder ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... IRVING, Texas , Sept. 7, 2017 /PRNewswire/ ... molecular science focused on fulfilling the promise of ... that further validate the benefits of its molecular ... Each study utilized comprehensive genomic profiling plus (CGP+) ... each individual patient,s tumor on a molecular level, ...
(Date:9/6/2017)... ANTONIO , Sept. 6, 2017  Robert G. ... a Pinnacle Professional Member in recognition of his contributions ... Szewc serves as a Nephrologist at the practice of ... emergency medicine, kidney care and hypertension solutions. He has ... 20 years of career experience, as well as expertise ...
(Date:9/6/2017)... Eli Lilly and Company (NYSE: ... for galcanezumab and lasmiditan, two investigational treatments for migraine, ... (IHC) taking place Sept. 7-10 in Vancouver ... long-term data from an open-label study evaluating the safety ... and 240 mg) for the prevention of migraine. Galcanezumab ...
Breaking Medicine Technology: