Navigation Links
Loss of protein SPDEF allows prostate cancer cells to gain foothold at possible sites of metastasis
Date:7/6/2012

Prostate cancer doesn't kill in the prostate it's the disease's metastasis to other tissues that can be fatal. A University of Colorado Cancer Center study published this week in the Journal of Biological Chemistry shows that prostate cancer cells containing the protein SPDEF continue to grow at the same pace as their SPDEF- cousins, but that these SPDEF+ cells are unable to survive at possible sites of metastasis.

"It's as if these cancer cells with SPDEF can't chew into distant tissue and so are unable to make new homes," says Hari Koul, PhD, investigator at the CU Cancer Center and director of urology research at the University of Colorado School of Medicine, the study's senior author.

Koul and his group discovered the homesteading power of cancer cells that have lost SPDEF by introducing a gene into cells that makes them glow in the presence of a dye, and then introducing them into the bloodstream of animal models. Cells without SPDEF traveled through the blood and successfully attached to tissue, surviving and so fluorescing many weeks later when dye was introduced. However, cells with SPDEF flowed through the blood but were unable to successfully establish new colonies and so soon died out.

In fact, the protein SPDEF doesn't act directly to allow cells to attach at possible metastasis sites, but is a transcription factor that controls the production (or lack thereof) of two other proteins MMP9 and MMP13. These two downstream proteins work to break down tissue, like a dissolving agent they are the cleaning crew that clears space for new and different growth, and in the case of prostate cancer metastasis they chip the tissue footholds that cancer cells need to create micrometastases.

"Given that MMP9 and perhaps MMP13 are also involved in metastasis of several other cancers including lung, ovarian, breast and colon to name a few, our findings could potentially have far-reaching consequences outside prostate cancer," adds Koul

The group's continuing work points in two directions.

"First, we hope that the presence of SPDEF could help doctors recognize prostate cancers that don't require treatment." If future studies confirm the group's initial findings, the presence of SPDEF could predict prostate cancers that are unable to metastasize and so unable to kill. These cancers could be left to run their course without the use of treatments that sometimes carry difficult side effects.

"And second," Koul says, "we hope to regulate expression of this protein to remove prostate cancers' ability to metastasize."

Koul points to small molecules, gene therapy or nanodelivery as possible mechanisms for introducing SPDEF into cells that lack the protein.

"With this discovery we have opened a hopeful door into a future in which prostate and potentially other cancers are unable to metastasize," Koul says.


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. The key (proteins) to self-renewing skin
2. Researchers discover rare leukemia-causing protein
3. PaleoMeal Organic Whey Protein Formula Improved According to Rockwell Nutrition
4. Moving 3D computer model of key human protein is powerful new tool in fight against cancer
5. Researchers reveal crucial immune fighter role of the STING protein
6. Protein residues kiss, dont tell
7. Overexpression of proteins 14-3-3 related to chemotherapy resistance
8. Wayne State University researcher examines proteins role in diabetic retinopathy
9. New molecular structure offers first picture of a protein family vital to human health
10. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
11. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... ... April 25, 2017 , ... Patients who would ... results in a fraction of the time as traditional braces – Wilckodontics®. Dr. ... Specialists, now offers this revolutionary treatment with or without a referral. , ...
(Date:4/25/2017)... ... ... MD is committed to providing the highest quality of spine care to all his patients. ... all my patients to alleviate possible future issues. I am pleased to have you as ... my trained staff will assist you in any way possible.” , Dr. Saad Chaudhary is ...
(Date:4/25/2017)... ... April 25, 2017 , ... Amendia, Inc., ... of its strategic partnership with and platinum sponsorship of Global Spine Outreach (“GSO”), ... and effective management of complex spine deformity cases, particularly in children. , GSO’s ...
(Date:4/24/2017)... ... April 24, 2017 , ... Ridgecrest Herbals makes it ... innovate new strategies to reduce waste, and support renewable energy. They believe this is ... to nature to find solutions for health issues, and maintain that destroying the environment ...
(Date:4/24/2017)... Calif. (PRWEB) , ... April 24, 2017 , ... The ... $1.6 million in charitable dental services to 1,961 people during the April 22-23 event ... at no charge to Californians who experience barriers to care, CDA Cares educates the ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)...  AbbVie (NYSE: ABBV), a global biopharmaceutical company, ... hepatitis C virus (HCV) infected patients with genotype ... cirrhosis (Child-Pugh A) achieved sustained virologic response at ... investigational, pan-genotypic regimen of glecaprevir/pibrentasvir (G/P). These high ... weeks of G/P treatment without ribavirin. Patients with ...
(Date:4/20/2017)... April 20, 2017 Research and Markets ... Contract Manufacturing Services Market Analysis By Service (Manufacturing, Research), By ... 2014 - 2025" report to their offering. ... The Latin American pharmaceutical contract ... by 2025 Low drug registration cost in Latin ...
(Date:4/19/2017)...  IRIDEX Corporation (Nasdaq: IRIX ) today ... first quarter 2017 after the close of trading on ... host a corresponding conference call beginning at 2:30 p.m. ... in listening to the conference call may do so ... 326-3030 for international callers, using conference ID: 92158987.  A ...
Breaking Medicine Technology: