Navigation Links
Loss of key protein boosts neuron loss in ALS
Date:3/4/2011

d out) during the development of mature messenger RNA. Introns, however, contain binding sites for RNA binding proteins such as TDP-43, to regulate the splicing process.

"This is an important finding as genes expressed in the central nervous system have much longer introns than genes expressed in any other tissues," said Yeo. "This may explain the neuronal selectivity of the disease, and why other types of cells aren't affected."

Third, TDP-43 affects the alternative splicing of many genes. In fact, it affects the alternative splicing of its own RNA message. Said Yeo: "This autoregulation keeps TDP-43 protein levels in check. The loss of TDP-43 removes this check; more TDP-43 is generated and more is likely to accumulate in the cytoplasm."

The deep and expansive impact of misaggregated TDP-43 and the concurrent loss of normal TDP-43 appear to extend beyond ALS. The protein is a central component in the pathogenesis of an ever-increasing list of neurodegenerative conditions. For example, accumulating abnormal TDP-43 in neuronal cytoplasm has been documented in frontotemporal lobar dementia, a neurological disorder that results in progressive changes in personality, the ability to concentrate, social skills, motivation and reasoning.

"It is likely that TDP-43 affects many other neurodegenerative diseases," said Yeo. "Our RNA targets probably reveal the set of genes important for maintaining the normal homeostasis of neurons."

Yeo said the team will now explore which TDP-43 binding sites are critical to how ALS begins and progresses. Ultimately, he said, the information could be used to design new drugs and therapies.


'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Penn researchers find new role for cancer protein p53
2. Protein and microRNA block cellular transition vital to metastasis
3. Protein fuels inflammation in pancreatic and breast tumors
4. Scientists bioengineer a protein to fight leukemia
5. Higher Levels of Blood Protein Linked to Lower Respiratory Risks
6. Overabundance of protein expands breast cancer stem cells
7. Scientists develop method to identify fleetingly ordered protein structures
8. Protein may be key to new treatment in a childhood cancer
9. Scripps Research scientists develop powerful new methodology for stabilizing proteins
10. Key Protein May Warn of Future Spread of Cancer
11. Communication pathways within proteins may yield new drug targets to stop superbugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... ,, , ... ... ... ... passed. , For the study, published this week in the peer-reviewed journal Quality of Life Research , a UCLA team led ...
(Date:7/30/2014)... VA (PRWEB) July 30, 2014 The ... 2014-2015 Board of Directors. Sandra Aiken Chack will serve ... month at the EDNF 2014 Annual Learning Conference in ... Foundation has an ambitious agenda ahead of us. From ... Care & Research at the Greater Baltimore Medical Center ...
(Date:7/30/2014)... LTC Consumer, an independent, free online service to help consumers ... Quote tool on its website, LTCconsumer.com , announced Nathan ... free and unlimited. , The Instant Quote tool ... age, gender, and state of residence – and delivers a ... enter any contact information to get started). There is no ...
(Date:7/30/2014)... The American Telemedicine Association (ATA) ... Cochran (R-MS) and Roger Wicker (R-MS) for their ... under Medicare, Medicaid and Federal Communications Commission programs. ... introduced the Telehealth Enhancement Act as S. 2662, ... 3306, introduced by Rep. Gregg Harper (R-MS) which ...
(Date:7/30/2014)... OR (PRWEB) July 30, 2014 ... evaluating the quality of care that their practitioners ... CEO, Mr. Andrew Rowe, discussed the importance of ... to improve physician performance and quality of care. ... effective practitioner evaluation, Mr. Rowe elaborated on setting ...
Breaking Medicine News(10 mins):Health News:Diverticulitis patients reveal psychological, physical symptoms long after acute attacks 2Health News:Diverticulitis patients reveal psychological, physical symptoms long after acute attacks 3Health News:Ehlers-Danlos National Foundation Announces New Leadership 2Health News:LTC Consumer Launches Online Tool for Getting Instant Long Term Care Insurance Estimates 2Health News:ATA Applauds Senators’ Push for Federal Telemedicine Improvements 2Health News:AllMed Webinar Helps Hospitals Optimize Practitioner Evaluations in Peer Review 2Health News:AllMed Webinar Helps Hospitals Optimize Practitioner Evaluations in Peer Review 3
... , WASHINGTON, Dec. 10 The Community Oncology Alliance (COA) ... may face closing their practices if critical Medicare reimbursement fixes ... of health care reform. , "Current health reform legislation before ... substantial cuts coming in January to cancer care," said Patrick ...
... , Helps PSI, DFID and USAID highlight progress ... Dec. 10 Emmy Award winning actress and PSI (Population ... donors and individuals who have contributed to the substantial decline ... past six years Zimbabwe has seen a dramatic reduction in ...
... tuberculosis bacteria use to coerce disease-fighting cells to switch ... the airways and other surfaces to protect and defend ... helping create tubercles: the small, rounded masses characteristic of ... numbers and spread to other locations. By ...
... drug developed to prevent the death of nerve cells after ... cells healthy and intact, an international team led by a ... Breast Cancer Research . Prof. Malka Cohen-Armon of ... a member of a family of phenanthridine derivatives developed ...
... of Medicine have developed a new model of skin cancer ... Src kinase is activated in human skin-cancer samples. ... in human squamous cell carcinomas of the skin. We modeled ... a member of Src family of proteins, in mouse skin," ...
... , "...it is also true that security does not exist ... water, or the medicine they need to survive ." - ... Day -- At his Nobel Peace Prize acceptance speech in Oslo, Norway, ... to medicines for all people as a prerequisite to security. The ...
Cached Medicine News:Health News:National Oncologist Group Warns: Current Health Care Reform Legislation Woefully Short in Addressing Cancer Care Crisis 2Health News:National Oncologist Group Warns: Current Health Care Reform Legislation Woefully Short in Addressing Cancer Care Crisis 3Health News:National Oncologist Group Warns: Current Health Care Reform Legislation Woefully Short in Addressing Cancer Care Crisis 4Health News:Emmy Award Winning Actress Debra Messing Visits Zimbabwe 2Health News:Emmy Award Winning Actress Debra Messing Visits Zimbabwe 3Health News:Mechanism discovered by which body's cells encourage tuberculosis infection 2Health News:Mechanism discovered by which body's cells encourage tuberculosis infection 3Health News:Finding the Achilles' heel of cancer 2Health News:New model of skin cancer provides insights on second-most common type of cancer 2Health News:GAA Calls on President Obama to Make Good on His Nobel Peace Prize Speech 2
(Date:7/30/2014)... , July 30, 2014 Stryker brand ambassadors ... week at the 3M Championship Champions Tour event near ... in Blaine . Stryker is the official joint ... Starting Friday, August 1 st through Sunday, August ... Mobility Zone; an on-site joint health destination located in the Pioneer ...
(Date:7/30/2014)... July 30, 2014 Cynosure, Inc. (NASDAQ: ... aesthetic treatments for non-invasive and minimally invasive applications, today announced ... Chief Operating Officer and Chief Financial Officer Timothy W. ... 2014.  Baker, 53, will continue to serve as CFO and ... , who remains Chairman and Chief Executive Officer. ...
(Date:7/30/2014)... Calif. , July 30, 2014 Silicon ... released a study today that examines the ... and medical device companies.  According to the annual report ... the biggest potential returns since SVB started tracking the ... of the IPO.  Built on solid healthcare M&A activity ...
Breaking Medicine Technology:Stryker Brand Ambassadors Fred Funk And Hal Sutton Set To Play At 3M Championship 2Stryker Brand Ambassadors Fred Funk And Hal Sutton Set To Play At 3M Championship 3Stryker Brand Ambassadors Fred Funk And Hal Sutton Set To Play At 3M Championship 4Stryker Brand Ambassadors Fred Funk And Hal Sutton Set To Play At 3M Championship 5Cynosure Appoints Chief Operating Officer and Chief Financial Officer Timothy W. Baker as President 2Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 2Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 3
... Armanino Consulting today announced that dpiX has ... and the integration of Microsoft Dynamics AX 2009 ... the production of digital X-ray sensors used in ... comprehensive business management solution for midsize and enterprise ...
... Foundation, in collaboration with Kessler Institute for Rehabilitation, announced ... exoskeleton investigational studies, which will commence October 17.  Made ... exoskeleton that enables wheelchair users to stand and walk. ... both its company name and product line on October ...
Cached Medicine Technology:Armanino Consulting Completes Integration of Microsoft Dynamics AX and Camstar MES for dpiX 2Armanino Consulting Completes Integration of Microsoft Dynamics AX and Camstar MES for dpiX 3Kessler Foundation Identifies Six Participants to Test Ekso 2Kessler Foundation Identifies Six Participants to Test Ekso 3Kessler Foundation Identifies Six Participants to Test Ekso 4
... Fast and easy voice access to information ... SoundAdvice is easy and intuitive, enabling you ... your keyboard. With the VoiceBox Voice Information ... about hundreds of subjects and topics and ...
... hand-held potential vision tester measures retinal acuity ... Potential vision testing requires two related ... RAM (formerly known as the Illuminated Near ... with a pinhole disc and hinged lens). ...
The ACCU-Beam® line of Surgical Microscope Accessories includes digital camera adaptors, beam splitters, objective lenses, fiber optic cables, and fiberoptic retrofits....
The ACCU-Beam® line of Surgical Microscope Accessories includes digital camera adaptors, beam splitters, objective lenses, fiber optic cables, and fiberoptic retrofits....
Medicine Products: