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Loss of gene promotes brain-tumor development, reduces survival, study finds
Date:1/6/2011

n tumor-cell growth and sensitivity to temozolomide, the most effective chemotherapy for glioblastoma. Finally, they compared these findings with the outcomes of 570 glioblastoma patients.

These investigations showed the following:

  • Restoring NFKBIA in tumor cells inhibited their growth and viability and increased the cells' sensitivity to temozolomide.
  • Restoring NFKBIA suppresses the growth of glioblastoma cells that are driven by overexpression of EGFR.
  • Patients with both copies of NFKBIA survive significantly longer than did patients with tumors that have lost a copy of the gene (131 weeks and 57 weeks, respectively).


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Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

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