Navigation Links
Loss of gene promotes brain-tumor development, reduces survival, study finds
Date:1/6/2011

COLUMBUS, Ohio New research shows that loss of a gene called NFKBIA promotes the growth of glioblastoma multiforme, the most common and deadly form of brain cancer, and suggests that therapies that stabilize this gene may improve survival for certain glioblastoma patients.

The study was published recently in the New England Journal of Medicine.

"We show that NFKBIA status may be an independent predictor of survival in certain patients with glioblastoma," says senior coauthor Dr. Arnab Chakravarti, chair and professor of Radiation Oncology and co-director of the Brain Tumor Program at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James).

"We also show that this gene plays a key role in glioblastoma behavior, and that it could be useful for predicting treatment outcomes," he says.

An estimated 18, 500 new cases of glioblastoma occur annually among Americans, resulting in 12,760 deaths. Average survival after diagnosis is about 12 to 15 months.

Most cases of the disease are driven by over activity of a gene called EGFR (epidermal growth factor receptor). This study shows that loss of NFKBIA (nuclear factor of kappa-light polypeptide gene enhancer in B-cells inhibitor-alpha) and overexpression EGFR are equally potent at driving glioblastoma development.

It also shows that glioblastoma tumors generally show either abnormally high levels of EGFR or loss of NFKBIA, but not both. Normal levels of both genes also occur.

Chakravarti, along with Markus Bredel, an adjunct associate professor of radiation oncology at Ohio State and their colleagues analyzed data from 790 cases of glioblastoma, which they divided into 10 study sets, for gene deletions, mutations, and expression of NFKBIA and EGFR.

Using glioblastoma cell lines and tumor cells from patients, they examined the influence of the NFKBIA gene o
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Father Channels His Grief into Advocacy, Promotes Simple Actions to Make Hospitals Safer for Children
2. BioMed Realty Trust Promotes Matthew G. McDevitt to Executive Vice President, Real Estate
3. Medical Transcription Services and EHR Provider MxSecure Promotes Tim Erkel to VP, Client Services
4. Hearts and Minds Promotes Wellness; African Americans Living with Mental Illness Have Higher Risk for Other Illnesses.
5. Pinstripe Promotes Jill Schwieters to President of Pinstripe Healthcare
6. Scientific exchange program promotes collaborative quality standards for drugs, food ingredients
7. Scientists find key to gene that promotes cancer metastasis
8. Microfluidics Promotes Scientific University Research Using Nanotechnology with Innovation Incentives
9. Brain Health Expert Says OASIS Promotes Brain Fitness
10. New Anti-Aging Skin Care Line Promotes Penetration
11. Gold Standard/Elsevier promotes medication safety and compliance via New MEDcounselor languages
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... (PRWEB) August 21, 2014 A new ... a 63% increase in disability associated with speech problems ... a more than 15% increase in disability associated with ... intervention for rising numbers of children who are experiencing ... (ASHA). , On a broader level, the ...
(Date:8/21/2014)... is to focus on her body in terms of ... her as a complete human being with thoughts and ... in the media, how does it affect individual romantic ... Quarterly , a SAGE journal, finds that more objectification ... incidents of sexual pressure and coercion., Researchers Laura R. ...
(Date:8/21/2014)... FRANCISCO Aug. 21, 2014 Researchers in the ... congenital cataracts can quickly and accurately diagnose a number ... a study published online today in ... Ophthalmology. Using a single test, doctors were able ... on their mutations reducing the time and money spent ...
(Date:8/21/2014)... 2014 Xarelto lawsuit ( http://www.xareltolawsuitcenter.com/ ) ... suffer uncontrollable internal bleeding and other serious injuries continue ... According to court documents, a wrongful death lawsuit was ... District of New York by the family of a ... that was allegedly caused by Xarelto. Among other thing, ...
(Date:8/21/2014)... 21, 2014 The report "Industrial ... Pollutant Control System (FGD, DeNOx, Particulate Control, Mercury ... Steel, Chemical & Others) - Global Trends & ... industrial flue gas treatment systems & services market ... size in terms of value. The industrial flue ...
Breaking Medicine News(10 mins):Health News:New Pediatrics Study Reveals Dramatic Increase in Speech Problems in Children Over Past Decade 2Health News:New Pediatrics Study Reveals Dramatic Increase in Speech Problems in Children Over Past Decade 3Health News:Objectification in romantic relationships related to sexual pressure and coercion 2Health News:New DNA test for diagnosing diseases linked to childhood blindness 2Health News:Xarelto Lawsuits Mount With New Filing in New York Federal Court, Bernstein Liebhard LLP Reports 2Health News:Xarelto Lawsuits Mount With New Filing in New York Federal Court, Bernstein Liebhard LLP Reports 3Health News:Xarelto Lawsuits Mount With New Filing in New York Federal Court, Bernstein Liebhard LLP Reports 4Health News:Industrial Flue Gas Treatment Systems Market Estimated to Worth $59, 546.7 Million by 2019 – Report by MarketsandMarkets 2Health News:Industrial Flue Gas Treatment Systems Market Estimated to Worth $59, 546.7 Million by 2019 – Report by MarketsandMarkets 3Health News:Industrial Flue Gas Treatment Systems Market Estimated to Worth $59, 546.7 Million by 2019 – Report by MarketsandMarkets 4
... WASHINGTON, July 22 The role of personal responsibility in ... Rethinking Responsibility: Reflections on Sex and Accountability. Released ... nonprofit, nonpartisan organization, the volume includes 29 essays written by leaders ... , Leading media voices, ...
... July 22 To help employers face the challenges of ... difficult economy, Sodexo, Inc., now offers a Quality of Life ... today the launch of the program designed to ... , , Sodexo, a ...
... , DALLAS, July 22 Texas ... Heart Association for providing quality, evidence-based care for coronary artery ... "This is another example of the dedication and commitment ... Dallas community by physicians, nursing, allied health professionals and administration," ...
... , WALNUT CREEK, Calif., July 22 ... cure with the recent approval by The National Institutes of Health ... scientists, parents and advocates. , , ... to highlight the work of the NIH,s Research Plan on Fragile ...
... demands of surgical careers, most surgeons would still choose their ... postpone having children or to not have children at all ... national survey conducted by UC Davis researchers has found. The ... Surgery , one of the JAMA/Archives journals. "Surgery is ...
... associated with varied, disproportionate, asymmetric overgrowth of many ... seen in Proteus syndrome is progressive and difficult ... treatment for the progressive overgrowth of tissue over ... functional and cosmetic consequences, so surgical intervention is ...
Cached Medicine News:Health News:National Leaders Examine Sex and Responsibility in New Book 2Health News:National Leaders Examine Sex and Responsibility in New Book 3Health News:Sodexo Offers Landmark Program to Promote Employee Health and Worklife Balance 2Health News:Texas Health Dallas Receives Double Honor From American Heart Association 2Health News:NIH Plan Charts Course to Better Treatments and Cure for Most Common Known Genetic Cause of Autism: Fragile X 2Health News:UC Davis study highlights work-life issues of female surgeons 2
(Date:8/21/2014)... 21, 2014   Memorial Hermann Health System and ... today announced a new partnership to provide a new level ... care centers in the greater Houston ... become the exclusive provider of professional breast radiology services for ... Memorial City, The Woodlands , Northeast, Southwest ...
(Date:8/21/2014)... Aug. 21, 2014  Publicis Groupe customer engagement ... Managing Partner and Healthcare Industry Group Leader, has been ... recognizes the most inspiring people in the life-sciences industry. ... research and development, marketing, technology, creativity, strategy and medicine. ... as a partner in its leading Rosetta Consulting practice. ...
(Date:8/21/2014)... HAMBURG, Germany , Aug. 21, 2014  IBM (NYSE: ... Deutsches Elektronen-Synchrotron ( DESY ), a leading national research ... up management and storage of massive volumes of x-ray ... architecture based on IBM software defined technology can handle ... peak performance and help scientists worldwide gain faster insights ...
Breaking Medicine Technology:Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 2Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 3Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 4Shannon Hartley Shines in PharmaVOICE 100 2DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3
... Tech acclaimed GT-CAPTURE digital camera photomicrographic system ... microscope such as Olympus, Leica, Nikon, and ... and transferring images over the Internet easy ... and a performance-proven Nikkor lens. The system ...
... superb stand-alone digital camera with networking capability ... or remote locations. Image acquisition and camera ... operates independently or attaches directly to a ... to capture and transfer images. Sharing images ...
... are a new generation of flexible CCD cameras, ... video imaging. Images are captured by a high-resolution ... and digital formats. Video signals include composite video, ... to the PC as uncompressed TIFF files. And ...
Console Horizontal Airflow Cabinet...
Medicine Products: