Navigation Links
Loss of gene promotes brain-tumor development, reduces survival, study finds
Date:1/6/2011

COLUMBUS, Ohio New research shows that loss of a gene called NFKBIA promotes the growth of glioblastoma multiforme, the most common and deadly form of brain cancer, and suggests that therapies that stabilize this gene may improve survival for certain glioblastoma patients.

The study was published recently in the New England Journal of Medicine.

"We show that NFKBIA status may be an independent predictor of survival in certain patients with glioblastoma," says senior coauthor Dr. Arnab Chakravarti, chair and professor of Radiation Oncology and co-director of the Brain Tumor Program at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James).

"We also show that this gene plays a key role in glioblastoma behavior, and that it could be useful for predicting treatment outcomes," he says.

An estimated 18, 500 new cases of glioblastoma occur annually among Americans, resulting in 12,760 deaths. Average survival after diagnosis is about 12 to 15 months.

Most cases of the disease are driven by over activity of a gene called EGFR (epidermal growth factor receptor). This study shows that loss of NFKBIA (nuclear factor of kappa-light polypeptide gene enhancer in B-cells inhibitor-alpha) and overexpression EGFR are equally potent at driving glioblastoma development.

It also shows that glioblastoma tumors generally show either abnormally high levels of EGFR or loss of NFKBIA, but not both. Normal levels of both genes also occur.

Chakravarti, along with Markus Bredel, an adjunct associate professor of radiation oncology at Ohio State and their colleagues analyzed data from 790 cases of glioblastoma, which they divided into 10 study sets, for gene deletions, mutations, and expression of NFKBIA and EGFR.

Using glioblastoma cell lines and tumor cells from patients, they examined the influence of the NFKBIA gene o
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Father Channels His Grief into Advocacy, Promotes Simple Actions to Make Hospitals Safer for Children
2. BioMed Realty Trust Promotes Matthew G. McDevitt to Executive Vice President, Real Estate
3. Medical Transcription Services and EHR Provider MxSecure Promotes Tim Erkel to VP, Client Services
4. Hearts and Minds Promotes Wellness; African Americans Living with Mental Illness Have Higher Risk for Other Illnesses.
5. Pinstripe Promotes Jill Schwieters to President of Pinstripe Healthcare
6. Scientific exchange program promotes collaborative quality standards for drugs, food ingredients
7. Scientists find key to gene that promotes cancer metastasis
8. Microfluidics Promotes Scientific University Research Using Nanotechnology with Innovation Incentives
9. Brain Health Expert Says OASIS Promotes Brain Fitness
10. New Anti-Aging Skin Care Line Promotes Penetration
11. Gold Standard/Elsevier promotes medication safety and compliance via New MEDcounselor languages
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... (PRWEB) , ... September 01, ... ... seeking better therapeutic options to efficiently cure and prevent different malignancies. Some ... cancers have different pathophysiological properties due to which distinctive approach is necessary ...
(Date:9/1/2015)... ... September 01, 2015 , ... Negative pressure wound ... a wound to remove exudates, fluid, and infectious materials to prepare the wound ... devices, disposable devices, and canisters, etc.) is projected to expand continuously through 2021. ...
(Date:9/1/2015)... ... September 01, 2015 , ... The ... Information Management has been granted continued accreditation based on a successfully completed ... ÔÇťAchieving and maintaining this accreditation takes the involvement and dedication of each ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... government entities, announced today that it has hired Scott Sanderson, an experienced business ... this capacity, Sanderson will be responsible for establishing and managing new client relationships ...
(Date:9/1/2015)... ... 2015 , ... WorkCare, Inc., a national occupational health services ... as an Associate Medical Director. , WorkCare specializes in workforce health protection ... abroad. , Dr. Nelson has a diverse background. He trained in sports ...
Breaking Medicine News(10 mins):Health News:CD Antigen Cancer Market and Pipeline Landscape Examined in Comprehensive Kuick Research Report Published at MarketPublishers.com 2Health News:CD Antigen Cancer Market and Pipeline Landscape Examined in Comprehensive Kuick Research Report Published at MarketPublishers.com 3Health News:World Negative Pressure Wound Therapy Market Assessed by GlobalData in In-demand Report Published at MarketPublishers.com 2Health News:World Negative Pressure Wound Therapy Market Assessed by GlobalData in In-demand Report Published at MarketPublishers.com 3Health News:Edge Information Management Granted Continued NAPBS Accreditation 2Health News:Edge Information Management Granted Continued NAPBS Accreditation 3Health News:Former NFL Standout Scott Sanderson Joins eDiscovery Leader Discovia 2Health News:Dr. Brent Nelson Joins WorkCare, Inc., as Associate Medical Director 2Health News:Dr. Brent Nelson Joins WorkCare, Inc., as Associate Medical Director 3
... Seeking Feedback on Revisions to Standards , , WASHINGTON, ... comprehensive review of its standards, URAC , ... for public comment on revisions to its Health ... Security standards . URAC welcomes purchasers, policy ...
... June 18 /PRNewswire-Asia-FirstCall/ -- Jiangbo,Pharmaceuticals Enterprises, Inc. (OTC ... company with its principal operations in the,People,s Republic ... the China New,Drugs Trade Fair from June 26 ... Exhibition Center, and also plans to launch a ...
... , DENVER, June 18 DaVita Inc. (NYSE: ... those diagnosed with chronic kidney disease (CKD), today announced the ... Work for in Colorado Program. DaVita(R) is the only ... , (Logo: http://www.newscom.com/cgi-bin/prnh/20020729/DAVITALOGO ) , , "We ...
... ... Southeast Asia,s largest private hospital and one of the world,s top medical travel destinations, ... Quality Class (TQC) award for 2008. , ... Bangkok, Thailand (PRWEB) June 18, 2009 -- Bumrungrad International ...
... ... has been validated by ACHC as an organization dedicated to quality patient services, and ... ... -- Homefront Diabetic Services proudly announces its award of accreditation status by the Accreditation ...
... approach to choosing the best treatment options for early breast ... in a report from the 11th St Gallen conference. ... Annals of Oncology [1] today (Thursday 18 June), and ... from the conference of more than 4,800 participants from 101 ...
Cached Medicine News:Health News:Public Comment Period Open for HIPAA Privacy and Security Standards 2Health News:Public Comment Period Open for HIPAA Privacy and Security Standards 3Health News:Public Comment Period Open for HIPAA Privacy and Security Standards 4Health News:Jiangbo Pharmaceuticals to Attend the 44th China New Drugs Trade Fair in Tianjin 2Health News:Jiangbo Pharmaceuticals to Attend the 44th China New Drugs Trade Fair in Tianjin 3Health News:DaVita Named One of Best Companies to Work for in Colorado 2Health News:Bumrungrad International the first private hospital to be awarded Thailand Quality Class (TQC) for organizational excellence 2Health News:Bumrungrad International the first private hospital to be awarded Thailand Quality Class (TQC) for organizational excellence 3Health News:Homefront Diabetic Services Completes Accreditation with ACHC 2Health News:St. Gallen consensus 2009: A radically different approach to treating early breast cancer 2Health News:St. Gallen consensus 2009: A radically different approach to treating early breast cancer 3
(Date:9/1/2015)... Sept. 1, 2015 Taiwan,s ... press conference in Taipei on  ... new Vaucarrin™ platform, a targeted drug delivery technology that ... This event was part of a joint press conference ... NanoTech Inc. (GNT), showcasing GNT,s latest edible gold-based food ...
(Date:9/1/2015)... 1, 2015 Agena Bioscience TM today announced ... , a commercial and financial hub from which many biotech ... testing laboratories in mainland China . ... Bioscience,s global sales with almost sixty MassARRAY ® Systems ... will allow us to expand our reach and foster ...
(Date:9/1/2015)... , 1. September 2015 In ... von 2.500 Mitarbeitern hat die SHL Group schnell ... konstantes und rapides Wachstum auf dem Markt ... die Produktivität und das Management von SHL wieder. ... SHL ist weltweit führend in Design und ...
Breaking Medicine Technology:GNTbm Updates Developments in the Vaucarrin(TM) annogold Drug Delivery Platform 2GNTbm Updates Developments in the Vaucarrin(TM) annogold Drug Delivery Platform 3GNTbm Updates Developments in the Vaucarrin(TM) annogold Drug Delivery Platform 4GNTbm Updates Developments in the Vaucarrin(TM) annogold Drug Delivery Platform 5Agena Bioscience Opens Office in Shanghai, China 2SHL Group erreicht wichtigen Markstein von 3.000 Mitarbeitern 2
... N.Y., Aug. 17, 2011 Polymedco is pleased ... Colorectal Cancer Screening in Integrated Health Care Systems" ... Burley, Juan Reyes, Michael Oehrli, and Cindy Caldwell ... screening program for Colorectal cancer (CRC) at Kaiser ...
... 17, 2011  ConvaTec, a world-leading developer and marketer ... today announced the appointments of Charles Cerminara and James ... has been appointed Vice President and General Manager, Greater ... on the growth of the Chinese market and to ...
Cached Medicine Technology:Polymedco Announces Publication in Epidemiologic Reviews 2ConvaTec Announces Asia-Pacific Leadership Appointments 2
3.2 mm Keratome, double bevel, sharp sides, ang. 1 Ea as quantity....
... the surgeon with high power performance and ... electrosurgical needs. 9000 volts peak to peak ... of pure cutting power make the Sabre ... is designed to meet the broadest range ...
LigaSure system generator, bipolar only. Designed to permanently seal vessels and tissue bundles....
Microcontroller-based isolated electrosurgical generator, designed for all general purpose surgical procedures. Unit includes: Instant Response technology, adaptive REM system, isolated output, CEM c...
Medicine Products: