Navigation Links
Loss of gene promotes brain-tumor development, reduces survival, study finds

COLUMBUS, Ohio New research shows that loss of a gene called NFKBIA promotes the growth of glioblastoma multiforme, the most common and deadly form of brain cancer, and suggests that therapies that stabilize this gene may improve survival for certain glioblastoma patients.

The study was published recently in the New England Journal of Medicine.

"We show that NFKBIA status may be an independent predictor of survival in certain patients with glioblastoma," says senior coauthor Dr. Arnab Chakravarti, chair and professor of Radiation Oncology and co-director of the Brain Tumor Program at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James).

"We also show that this gene plays a key role in glioblastoma behavior, and that it could be useful for predicting treatment outcomes," he says.

An estimated 18, 500 new cases of glioblastoma occur annually among Americans, resulting in 12,760 deaths. Average survival after diagnosis is about 12 to 15 months.

Most cases of the disease are driven by over activity of a gene called EGFR (epidermal growth factor receptor). This study shows that loss of NFKBIA (nuclear factor of kappa-light polypeptide gene enhancer in B-cells inhibitor-alpha) and overexpression EGFR are equally potent at driving glioblastoma development.

It also shows that glioblastoma tumors generally show either abnormally high levels of EGFR or loss of NFKBIA, but not both. Normal levels of both genes also occur.

Chakravarti, along with Markus Bredel, an adjunct associate professor of radiation oncology at Ohio State and their colleagues analyzed data from 790 cases of glioblastoma, which they divided into 10 study sets, for gene deletions, mutations, and expression of NFKBIA and EGFR.

Using glioblastoma cell lines and tumor cells from patients, they examined the influence of the NFKBIA gene on tumor-cell growth and sensitivity to temozolomide, the most effective chemotherapy for glioblastoma. Finally, they compared these findings with the outcomes of 570 glioblastoma patients.

These investigations showed the following:

  • Restoring NFKBIA in tumor cells inhibited their growth and viability and increased the cells' sensitivity to temozolomide.
  • Restoring NFKBIA suppresses the growth of glioblastoma cells that are driven by overexpression of EGFR.
  • Patients with both copies of NFKBIA survive significantly longer than did patients with tumors that have lost a copy of the gene (131 weeks and 57 weeks, respectively).


Contact: Darrell E. Ward
Ohio State University Medical Center

Related medicine news :

1. Father Channels His Grief into Advocacy, Promotes Simple Actions to Make Hospitals Safer for Children
2. BioMed Realty Trust Promotes Matthew G. McDevitt to Executive Vice President, Real Estate
3. Medical Transcription Services and EHR Provider MxSecure Promotes Tim Erkel to VP, Client Services
4. Hearts and Minds Promotes Wellness; African Americans Living with Mental Illness Have Higher Risk for Other Illnesses.
5. Pinstripe Promotes Jill Schwieters to President of Pinstripe Healthcare
6. Scientific exchange program promotes collaborative quality standards for drugs, food ingredients
7. Scientists find key to gene that promotes cancer metastasis
8. Microfluidics Promotes Scientific University Research Using Nanotechnology with Innovation Incentives
9. Brain Health Expert Says OASIS Promotes Brain Fitness
10. New Anti-Aging Skin Care Line Promotes Penetration
11. Gold Standard/Elsevier promotes medication safety and compliance via New MEDcounselor languages
Post Your Comments:
(Date:12/1/2015)... FL (PRWEB) , ... December 01, 2015 , ... ... announces the Multi Jar, a container patent that allows for easier packing and organizing ... the US is worth $90 billion," says Scott Cooper, CEO and Creative Director of ...
(Date:12/1/2015)... ... ... Royal River Natural Foods — a locally-owned, independent natural health store in ... nutritional supplement creatine, along with resistance training for a year, had more new bone ... report is part of the December 2015 issue of Natural Insights for Well Being®, ...
(Date:12/1/2015)... ... December 01, 2015 , ... According to an article published ... discrimination claim against the U.S. Department of Health and Human Services, claiming that any ... plans are breaking the clause in the law prohibiting the denial of coverage for ...
(Date:12/1/2015)... ... December 01, 2015 , ... Califia Farms , one of ... iconic bottle has won top honors in Beverage World Magazine’s Global Packaging Design Awards, ... that it has been selected as a 2015 U.S.A. Taste Champion in the American ...
(Date:12/1/2015)... ... ... Growth in medical payments per workers’ compensation claim in Louisiana slowed from ... care, according to a recent study by the Workers Compensation Research Institute (WCRI). ... payments per claim with more than seven days of lost time continued to be ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... 2015 ... "Medium Molecular Weight Polyisobutylene Market for ... Applications - Global Industry Analysis, Size, Share, ... report to their offering. --> ... of the "Medium Molecular Weight Polyisobutylene ...
(Date:12/1/2015)... /PRNewswire/ -- Royal Philips  (NYSE: PHG, ... imaging software that produces high-contrast images for all anatomies ... grid, at the 2015 Radiological Society of North ... Philips, first digital imaging solution providing grid-like contrast improvement ... workflow and supports "first-time-right imaging" by decreasing the need ...
(Date:12/1/2015)... 2015  Athletic apparel company Tommie Copper ... pay $1.35 million to settle Federal Trade Commission ... compression clothing would relieve severe and chronic pain ... Tommie Copper,s proposed settlement ... its founder and chairman Thomas Kallish ...
Breaking Medicine Technology: