Navigation Links
Loss of gene function makes prostate cancer cells more aggressive
Date:2/2/2010

DALLAS Feb. 2, 2010 Prostate cancer cells are more likely to spread to other parts of the body if a specific gene quits functioning normally, according to new data from researchers at UT Southwestern Medical Center.

Certain prostate cancer cells can be held in check by the DAB2IP gene. The gene's product, the DABIP protein, acts as scaffolding that prevents many other proteins involved in the progression of prostate cancer cells from over-activation. When those cells lose the DAB2IP protein, however, they break free and are able to metastasize, or spread, drastically increasing the risk of cancer progression in other organs as the cells travel through the bloodstream or lymph system.

The study in mice, published in the Jan. 11 issue of the Proceedings of the National Academy of Sciences, found that eliminating the DAB2IP scaffolding in human carcinoma cells caused them to change from epithelial cells to mesenchymal cells a hallmark of metastatic cancer.

Cells undergoing an epithelial to mesenchymal transition (EMT) experience biological changes that enable them to move freely and spontaneously throughout the body," said Dr. Jer-Tsong Hsieh, director of the Jean H. & John T. Walker Jr. Center for Research in Urologic Oncology at UT Southwestern and the study's senior author. "By restoring DAB2IP function in cancer cells in mice, we reversed their ability to change and metastasize."

Dr. Hsieh said identifying the DAB2IP protein in human cells might serve as a biomarker, helping physicians identify patients who could have more aggressive, metastatic forms of prostate cancer.

EMT is known to play an important role in embryo implantation, embryogenesis and organ development, and tissue regeneration, as well as in cancer progression and metastasis. For cancer progression, EMT is believed to facilitate the migratory and invasive ability of cancer cells.

"Carcinoma cells undergo several changes that enabl
'/>"/>

Contact: Katherine Morales
katherine.morales@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Decreased muscle strength predicts functional impairments in older adults
2. Anesthetic approach stops pain without affecting motor function
3. Poor Mental Functioning May Predict Stroke
4. Anesthetic Approach Stops Pain Without Affecting Motor Function
5. COPD, even when mild, limits heart function
6. Stem Cells Become Functioning Neurons in Mice
7. Erectile Dysfunction Predicts Heart Disease
8. MessageSolution Releases Enterprise Migration System, the First Multi-Functional Migration/Archiving System in the Market, at IBM's Lotusphere 2010
9. Sexual function does not continuously decline after radiation therapy treatments for prostate cancer
10. Study links restless leg syndrome with erectile dysfunction in older men
11. American Journal of Sports Medicine Study Finds Arthroscopic Shoulder Surgery Can Improve Pain Relief and Shoulder Function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... MD, was recently invited to submit a review ... Microbiology , one of the world,s foremost scientific ... specialist, and chair of the Department of Pediatrics ... analyzed the epidemiology and microbiology of co-infections during ... as more recent 2009 novel H1N1 pandemic. ...
(Date:4/17/2014)... Il. (April 17, 2014) Doctors who treat ... called lymphangioleiomyomatosis (LAM) can face an agonizing treatment ... of the disease and help relieve shortness of ... transplants, and sirolimus can cause potentially fatal complications ... pulmonologist Dr. Daniel Dilling, medical director of Loyola ...
(Date:4/17/2014)... CHICAGO, IL, April 17, 2014-- Colic affects about one ... accounts for numerous pediatric visits during the first several ... of colic symptoms was showing promise; however, the April ... (BMJ2014;348:g2107; Sung, Valerie) reported on a study, "Probiotics ... probiotic L reuteri for infant colic ...
(Date:4/17/2014)... EcoHealth Alliance, a nonprofit organization that focuses on ... review today examining the current state of knowledge of ... for improved global surveillance strategies to combat the emergence ... Ebola in West Africa that has claimed the lives ... Liberia. According to the World Health Organization (WHO), ...
(Date:4/17/2014)... An international research team led by Cesar A. Arias, ... Center at Houston (UTHealth) has identified a new superbug ... The report appeared in the April 17 issue of ... The new superbug is part of a class of ... or MRSA, which is a major cause of hospital ...
Breaking Medicine News(10 mins):Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 3Health News:New MRSA superbug emerges in Brazil 2
... But new poll shows two-thirds just accept it and do best ... Americans are working later and sleeping less, a dangerous combination which ... lack of interest in sex. , And while most people know ... about it, a new poll shows. , "People are actually acknowledging ...
... Awareness Week (March 2-8), the Association for Professionals in,Infection ... can take to become their own advocate and reduce ... Visit http://www.apic.org during Patient Safety Awareness ... Most people invest more time into selecting a ...
... OTTAWA, Canada, March 3 ,InterACTIVE Nutrition International ... Bulletin Board: NTNI) http://www.naturalnutritioninc.com has ... Nutrition,s Ottawa based,manufacturing facility, InterACTIVE Nutrition, Inc., ... of health conscious consumers in Iraq. The ...
... to raise awareness and advocate for affordable health coverage. ... ... DETROIT, March 3 Leaders from throughout Michigan,including representatives of insurers, ... supporters of the newly formed,Michigan Cover The Uninsured Network (MCTUN). The ...
... example of another,news article, in a respected outlet (Yahoo), ... need it is a good idea., (I,m not ... see this argument being presented by ,credible, members of ... news outlet.), This time, they,re* going after whether ...
... Smith & Nephew,Inc.,s (NYSE: SNN ; ... approval of its award winning OXINIUM(TM),oxidized zirconium technology., ... company to offer such a,revolutionary and award winning ... alloy with a ceramic bearing surface. OXINIUM,provides low ...
Cached Medicine News:Health News:Americans Sleepier Than Ever 2Health News:Americans Sleepier Than Ever 3Health News:APIC Issues Recommendations on How to Have a Healthy Hospital Stay 2Health News:Natural Nutrition Ships First InterACTIVE Nutrition Brand Products to Iraq 2Health News:Michigan Leaders Join Network to Push for Coverage of State's 1.4 Million Uninsured 2Health News:Putting an End to Medical Cruelty: A Horrifying Article in Yahoo this Week by T. L. Kittle 2Health News:Putting an End to Medical Cruelty: A Horrifying Article in Yahoo this Week by T. L. Kittle 3Health News:Smith & Nephew Wins OXINIUM(TM) Approval in Japan 2Health News:Smith & Nephew Wins OXINIUM(TM) Approval in Japan 3
(Date:1/15/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) announces that ... to the announced tender offer for all of the outstanding shares ... of the waiver, the transaction is no longer conditional on OFT ... 24, 2014 following the currently scheduled expiration time, subject to the ...
(Date:1/15/2014)... , Jan. 15, 2014 Tegra Medical is very ... King as its new Chief Executive Officer.  Mark was ... which he has overseen the company,s four facilities in ... Costa Rica.  Mr. King joined Tegra Medical in 2012 with ...
(Date:1/15/2014)... NEW YORK , Jan. 15, 2014 ... research report is available in its catalogue: ... & Forecast – Worldwide Analysis ... Pump Market Analysis ...
Breaking Medicine Technology:Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17
Large, bright images from a bronchoscope designed for routine examination and treatment....
... the first in a series of bronchofiberscopes ... features necessary to meet the demand for ... scope includes a new control section and ... It also provides a wider field of ...
... Double lumen ... one-lung ventilation., ... Tube is packaged ... tube-to-circuit adaptors, suction ...
... Used for endobronchial blockade ... right lung for procedures ... The set consists of ... and an Arndt Multiport ...
Medicine Products: