Navigation Links
Loss of function of a single gene linked to diabetes in mice
Date:1/3/2014

ng beta cells. All such mice had elevated blood glucose levels, which the researchers found was due to insufficient release of insulin.

"We didn't see any insulin resistance in their cells, but it was clear that the beta cells were not functioning properly," Prabhakar said. Examination of the beta cells revealed that they were packed with insulin. "The cells were producing plenty of insulin, they just weren't secreting it," he said.

The finding shows that type 2 diabetes can be directly caused by the loss of a properly functioning MADD gene alone, Prabhakar said. "Without the gene, insulin can't leave the beta cells, and blood glucose levels are chronically high."

Prabhakar now hopes to investigate the effect of a drug that allows for the secretion of insulin in MADD-deficient beta cells.

"If this drug works to reverse the deficits associated with a defective MADD gene in the beta cells of our model mice, it may have potential for treating people with this mutation who have an insulin-secretion defect and/or type 2 diabetes," he said.


'/>"/>

Contact: Sharon Parmet
sparmet@uic.edu
312-413-2695
University of Illinois at Chicago
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Moffitt researchers find cancer therapies affect cognitive functioning among breast cancer survivors
2. New technique may help severely damaged nerves regrow and restore function
3. CNIO researchers describe new functions of cohesin relevant for human disease
4. Erectile dysfunction drug may benefit cardiac function in young patients with heart defects
5. Mild traumatic brain injury may contribute to brain network dysfunction
6. Secondhand Smoke May Harm Heart Function
7. Doctors Restore Some Hand Function to Quadriplegic Patient
8. Scientists study serious immune malfunction
9. Oxytocin improves brain function in children with autism
10. Bad Fat May Hurt Brain Function Over Time
11. Vitamin C improves pulmonary function in newborns of pregnant smoking women
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Loss of function of a single gene linked to diabetes in mice
(Date:7/28/2014)... Dotinga HealthDay Reporter MONDAY, ... humans just milliseconds to look at someone,s face and judge ... finds that certain facial features seem to trigger specific first ... size of the mouth, for example, appear directly linked to ... attractiveness. The study findings suggest that first impressions ...
(Date:7/28/2014)... New York, NY (PRWEB) July 28, 2014 ... ) filed on behalf of individuals who were ... Hip Replacement System continue to move forward in U.S. ... reports. According to an Order issued on July 18, ... of a motion filed by the Plaintiffs’ Steering Committee ...
(Date:7/28/2014)... Ticket Down is a dependable source ... FL at the Sun Life Stadium in early September. ... and Brazil has is one that has continues to go ... forming on a consistent basis. The rivalry between South ... the recent 2014 World Cup. To the delight of ...
(Date:7/28/2014)... July 28, 2014 (HealthDay News) -- Endurance runners are ... an undetected heart condition, according to a new study. ... participating in events in warm climates are actually 10 ... stroke. Yet, the less common sudden death of a ... problems, such as an irregular heartbeat, often gets a ...
(Date:7/28/2014)... Parker Waichman LLP, a personal injury law firm ... heroes of 9/11 are never forgotten, comments that the September ... According to a VCF message dated July 3, ... or before October 12, 2012 must file a Registration Form ... who were allegedly injured by the toxic dust cloud that ...
Breaking Medicine News(10 mins):Health News:Facial Dimensions May Be Key to First Impressions 2Health News:Facial Dimensions May Be Key to First Impressions 3Health News:DePuy Pinnacle Lawsuit News: New Order Issued in Federal Pinnacle Hip Implant Litigation, Bernstein Liebhard LLP Reports 2Health News:DePuy Pinnacle Lawsuit News: New Order Issued in Federal Pinnacle Hip Implant Litigation, Bernstein Liebhard LLP Reports 3Health News:DePuy Pinnacle Lawsuit News: New Order Issued in Federal Pinnacle Hip Implant Litigation, Bernstein Liebhard LLP Reports 4Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for Sept. 5th Showdown 2Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for Sept. 5th Showdown 3Health News:Heat Stroke a Greater Threat to Endurance Runners Than Heart Problems: Study 2Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 2Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 3
... of Health Care Reform, Received More Industry Contributions ... insurers and pharmaceutical manufacturers contributed $5.5 million to ... and House of Representatives during the last two ... care reform dominated political discourse, according to the ...
... VirtualHealth Technologies, Inc. (OTC Bulletin Board: VHGI) announced ... has changed it,s name to Secure eHealth, LLC to ... to Jim Renfro, VHGI President "This name change is ... our company,s commitment on growing our opportunities in this ...
... researchers report bedridden patients walked 24 hours after treatment ... cement" into lesions in patients whose cancer has spread ... rise from their deathbeds and live the remainder of ... these findings Monday at the Society of Interventional Radiology ...
... N.J., March 9 CANTEL MEDICAL CORP. (NYSE: ... $3,774,000, or $0.23 per diluted share, on a 2.5% increase in ... This compares with net income of $2,157,000, or $0.13 per diluted ... 31, 2008. For the six months ended January 31, 2009, the ...
... Biomedical Corporation (TSX: RBM, OTCBB: RPBIF) announced that ... of the Year by LifeSciences British Columbia. This ... to recognize an organization that has made outstanding ... sciences industry and to increase public awareness and ...
... expert says regular colon cancer screening should start at age ... keep talk about colons behind the bathroom door.It,s time to ... at the University of Michigan Health System.Regular wear ... diverticula in one in three adults over the age of ...
Cached Medicine News:Health News:Consumer Watchdog: Health Insurers & Drug Companies Contributed $5.5 Million to Top 10 Senate and House Recipients Since 2005 2Health News:Consumer Watchdog: Health Insurers & Drug Companies Contributed $5.5 Million to Top 10 Senate and House Recipients Since 2005 3Health News:Consumer Watchdog: Health Insurers & Drug Companies Contributed $5.5 Million to Top 10 Senate and House Recipients Since 2005 4Health News:Consumer Watchdog: Health Insurers & Drug Companies Contributed $5.5 Million to Top 10 Senate and House Recipients Since 2005 5Health News:Envoii Healthcare, LLC is now Secure eHealth, LLC 2Health News:Envoii Healthcare, LLC is now Secure eHealth, LLC 3Health News:Bone Cement Eases Pain of Late-Stage Cancers 2Health News:Bone Cement Eases Pain of Late-Stage Cancers 3Health News:Cantel Medical Reports 75% Increase in Net Income - EPS of $0.23 vs. $0.13 for Quarter Ended January 31, 2009 2Health News:Cantel Medical Reports 75% Increase in Net Income - EPS of $0.23 vs. $0.13 for Quarter Ended January 31, 2009 3Health News:Cantel Medical Reports 75% Increase in Net Income - EPS of $0.23 vs. $0.13 for Quarter Ended January 31, 2009 4Health News:Cantel Medical Reports 75% Increase in Net Income - EPS of $0.23 vs. $0.13 for Quarter Ended January 31, 2009 5Health News:Cantel Medical Reports 75% Increase in Net Income - EPS of $0.23 vs. $0.13 for Quarter Ended January 31, 2009 6Health News:Cantel Medical Reports 75% Increase in Net Income - EPS of $0.23 vs. $0.13 for Quarter Ended January 31, 2009 7Health News:Response Biomedical Named Medical Device Company of the Year by LifeSciences British Columbia 2Health News:Keep Your Colon Healthy With Exercise, Healthy Foods 2Health News:Keep Your Colon Healthy With Exercise, Healthy Foods 3
(Date:7/28/2014)... 2014  Syneron Medical Ltd. (NASDAQ: ELOS ... that its new PicoWay® device has received CE Mark ... and pigmented lesions on any skin type. PicoWay is ... and 1064nm wavelengths, which utilizes Syneron,s proprietary PicoWay technology ... are trillionths of a second, known as picosecond pulses. ...
(Date:7/28/2014)... (NYSE: RMD ), an innovator and pioneer ... and other chronic respiratory conditions, has won a permanent ... medical device manufacturer APEX Medical Corp. (APEX), prohibiting sales ... 220 masks.  The judgment was entered by the Regional ... appealable, and applies throughout Germany.  The ...
(Date:7/28/2014)... NEW PROVIDENCE, N.J. , July 28, 2014 ... to meet with Linde,s Healthcare division experts at ... held at McCormick Place in Chicago, Illinois ... demand nothing less than complete confidence in a reliable ... Healthcare Segment manager. "Linde understands the importance of this ...
Breaking Medicine Technology:Syneron Announces CE Mark for PicoWay Dual Wavelength Picosecond Laser for Tattoo Removal and Treatment of Pigmented Lesions 2Syneron Announces CE Mark for PicoWay Dual Wavelength Picosecond Laser for Tattoo Removal and Treatment of Pigmented Lesions 3Syneron Announces CE Mark for PicoWay Dual Wavelength Picosecond Laser for Tattoo Removal and Treatment of Pigmented Lesions 4ResMed Receives Permanent Injunction against APEX in Germany, Continues Enforcement of Patents in Europe 2Linde's Healthcare division to display new Hospital Services platform at the national ASHE Conference in Chicago 2
... Eli Lilly and Company,s (NYSE: LLY ... set to launch. Through the program, the company is ... that often lack basic resources. While serving others, the ... of different cultures and see firsthand the complex problems ...
... 2011 Patient Safety Technologies, Inc. (the "Company") (OTC ... closing of a $7.1 million common stock financing.  The ... several existing shareholders and certain members of senior management, ... price of $0.75 per share.  Proceeds from the offering ...
Cached Medicine Technology:Lilly's Connecting Hearts Abroad Program Sends Employees on Global Service Assignments 2Lilly's Connecting Hearts Abroad Program Sends Employees on Global Service Assignments 3Lilly's Connecting Hearts Abroad Program Sends Employees on Global Service Assignments 4Lilly's Connecting Hearts Abroad Program Sends Employees on Global Service Assignments 5Patient Safety Technologies, Inc. Closes $7.1 Million Common Stock Offering 2
... Simple, cost-effective microfiltration for your transfusion ... also brings you an easy and ... of microfiltration for a variety of ... postoperative applications, autologous or homologous transfusions, ...
This high technology cast plaster cutter saw is very easy and comfortable to use....
... Designed to reduce noise to a minimum ... and less hearing trauma for the clinician. ... high power in a smaller, lighter package. ... saw's balance and ergonomics for more user ...
The True/Fix Cannulated Bone Screw System contains 7.0mm large cannulated bone screws and 3.5mm cortical and 4.0mm cannulated cancellous bone screws....
Medicine Products: