Navigation Links
Loss of Y chromosome can explain shorter life expectancy and higher cancer risk for men

It is generally well known that men have an overall shorter life expectancy compared to women. A recent study, led by Uppsala University researchers, shows a correlation between a loss of the Y chromosome in blood cells and both a shorter life span and higher mortality from cancer in other organs.

Men have a shorter average life span than women and both the incidence and mortality in cancer is higher in men than in women. However, the mechanisms and possible risk factors behind this sex-disparity are largely unknown. Alterations in DNA of normal cells accumulate throughout our lives and have been linked to diseases such as cancer and diabetes.

In a study recently published in the journal Nature Genetics an international team of researchers have analysed the DNA in blood samples from a group of more than 1,600 elderly men. They found that the most common genetic alteration was a loss of the Y chromosome in a proportion of the white blood cells.

The group of men was studied for many years and the researchers could detect a correlation between the loss of the Y chromosome and shorter survival.

"Men who had lost the Y chromosome in a large proportion of their blood cells had a lower survival, irrespective of cause of death. We could also detect a correlation between loss of the Y chromosome and risk of cancer mortality", says Lars Forsberg, researcher at the Department of Immunology, Genetics and Pathology, Uppsala University, who has led the study.

The Y chromosome is only present in men and the genes contained on the Y chromosome have so far mostly been associated with sex determination and sperm production.

"You have probably heard before that the Y chromosome is small, insignificant and contains very little genetic information. This is not true. Our results indicate that the Y chromosome has a role in tumour suppression and they might explain why men get cancer more often than women. We believe that analyses of the Y chromosome could in the future become a useful general marker to predict the risk for men to develop cancer", says Jan Dumanski, professor at the Department of Immunology, Genetics and Pathology, Uppsala University, and responsible for the study.


Contact: Jan Dumanski
Uppsala University

Related medicine news :

1. Cost-effective method accurately orders DNA sequencing along entire chromosomes
2. Mutations in cancer often affect the X chromosome
3. Unstable chromosomes linked to less favorable response to RT and surgery in prostate cancer patients
4. Chromosome 21 abnormality tells oncologists to treat pediatric ALL more aggressively
5. Spanish researchers link cancer to failures in chromosome protection for the first time
6. Dual systems key to keeping chromosomes intact
7. New Comprehensive Chromosome Screening Program at Pacific Fertility Center Refines Embryo Selection, Improves Pregnancy Rates
8. Blame Common Colds on Your Chromosome Caps?
9. Scientists discover how chromosomes keep their loose ends loose
10. Caloric restriction has a protective effect on chromosomes
11. Research reveals new understanding of X chromosome inactivation
Post Your Comments:
Related Image:
Loss of Y chromosome can explain shorter life expectancy and higher cancer risk for men
(Date:11/27/2015)... ... November 27, 2015 , ... Lizzie’s Lice Pickers just announced ... offering customers 10% off of their purchase of lice treatment product. In addition, customers ... According to a company spokesperson. “Finding lice is a sure way to ruin the ...
(Date:11/27/2015)... ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community in the world, revealed that ... ). More than 3.7 billion people under the age of 50 – or 67% ... WHO's first global estimates of HSV-1 infection . , "The data shocks us highly!" ...
(Date:11/27/2015)... ... November 27, 2015 , ... A simply groundbreaking television series, ... interesting show that delves into an array of issues that are presently affecting Americans. ... from open dialogue, this show is changing the subjects consumers focus on, one episode ...
(Date:11/27/2015)... Angeles, CA (PRWEB) , ... November 27, 2015 , ... ... Commission on Accreditation of Allied Health Education Programs (CAAHEP) awarded accreditation to its Diagnostic ... list of CAAHEP accredited colleges, as only one of twelve colleges and universities in ...
(Date:11/27/2015)... ... 27, 2015 , ... Avid collector, Andrew Hawley from Vintage Rock Posters, announces ... This is one of Joplin's most famous and beautiful concert posters. The concert was ... in Ann Arbor. The According to Hawley, "It is hard to believe that Joplin's ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... November 27, 2015 ... --> Medical alert ... system (PERS) market is expected ... years with APAC being the ... see a high CAGR between ...
(Date:11/26/2015)... UTRECHT, the Netherlands , November 26, 2015 /PRNewswire/ ...   A new combination approach blends immunotherapy ... --> A new combination approach blends immunotherapy with ... A new combination approach blends immunotherapy with ... the Netherlands has found that immunotherapy ...
(Date:11/26/2015)... Research and Markets ( ) has announced ... Outlook to 2019 - Rise in Cardiac Disorders and Growing ... to their offering. Boston ... scientific and others. --> The market ... Boston scientific and others. ...
Breaking Medicine Technology: