Navigation Links
Losing more than 15 percent of body weight significantly boosts vitamin D levels in overweight women

SEATTLE Overweight or obese women with less-than-optimal levels of vitamin D who lose more than 15 percent of their body weight experience significant increases in circulating levels of this fat-soluble nutrient, according to a new study by researchers at Fred Hutchinson Cancer Research Center.

"Since vitamin D is generally lower in persons with obesity, it is possible that low vitamin D could account, in part, for the link between obesity and diseases such as cancer, heart disease and diabetes," said Caitlin Mason, Ph.D., lead author of the paper, published online May 25 in the American Journal of Clinical Nutrition. "Determining whether weight loss helps change vitamin D status is important for understanding potential avenues for disease prevention," said Mason, a postdoctoral research fellow in the Hutchinson Center's Public Health Sciences Division.

According to the National Institutes of Health, vitamin D plays many important roles in the body. It promotes calcium absorption and is needed for bone growth and bone healing. Along with calcium, vitamin D helps protect older adults from osteoporosis. The nutrient also influences cell growth, neuromuscular and immune function, and reduces inflammation. Many gene-encoding proteins that regulate cell proliferation, differentiation, and apoptosis (programmed cell death) are modulated in part by the vitamin.

The year-long study one of the largest ever conducted to assess the effect of weight loss on vitamin D involved 439 overweight-to-obese, sedentary, postmenopausal Seattle-area women, ages 50 to 75, who were randomly assigned to one of four groups: exercise only, diet only, exercise plus diet and no intervention.

Those who lost 5 percent to 10 percent of their body weight equivalent to approximately 10 to 20 pounds for most of the women in the study through diet and/or exercise saw a relatively small increase in blood levels of vitamin D (about 2.7 nanograms per milliliter, or ng/mL), whereas women who lost more than 15 percent of their weight experienced a nearly threefold increase in vitamin D (about 7.7 ng/mL), independent of dietary intake of the nutrient.

"We were surprised at the effect of weight loss greater than 15 percent on blood vitamin D levels," said senior author Anne McTiernan, M.D., Ph.D., director of the Hutchinson Center's Prevention Center and principal investigator of the study. "It appears that the relationship between weight loss and blood vitamin D is not linear but goes up dramatically with more weight loss. While weight loss of 5 percent to 10 percent is generally recommended to improve risk factors such as blood pressure, cholesterol and blood sugars, our findings suggest that more weight loss might be necessary to meaningfully raise blood vitamin D levels."

About 70 percent of the participants had less-than-optimal levels of vitamin D when the study began; at baseline, the mean blood level of vitamin D among the study participants was 22.5 ng/mL. In addition, 12 percent of the women were at risk of vitamin D deficiency (blood levels of less than 12 ng/mL).

The optimal circulating range of vitamin D is thought to be between 20 and 50 ng/mL, according to a recent data review conducted by the Institute of Medicine, which found that blood levels under 20 ng/mL are inadequate for bone health and levels over 50 ng/mL are associated with potential adverse effects, such as an increased risk of developing kidney stones.

Vitamin D is naturally found in some foods, such as fatty fish, and is produced within the body when skin is exposed to sunlight. According to the Institute of Medicine, just 10 minutes of sun a day is enough to trigger adequate vitamin D production. The estimated average requirement via diet or supplementation is 400 international units per day for most adults.

"It is always best to discuss supplementation with your doctor, because circulating levels can vary a lot depending on factors such as age, weight, where you live, and how much time you spend outdoors," Mason said. Vitamin D levels tend to decrease as people age and are generally lower among those with dark skin.

It is thought that obese and overweight people have lower levels of vitamin D because the nutrient is stored in fat deposits. During weight loss, it is suspected that the vitamin D that is trapped in the fat tissue is released into the blood and available for use throughout the body.

"Vitamin D is found in several different forms in the body and its pathways of action are very complex, so the degree to which vitamin D becomes available to the body as a result of weight loss is not well understood," Mason cautioned.

A possible link between vitamin D deficiency and chronic diseases, including cancer and heart disease, is also not well established. "More targeted research ongoing at the Hutchinson Center and elsewhere aims to better understand whether vitamin D plays a specific role in the prevention of these chronic diseases," McTiernan said. To that end, McTiernan is recruiting Seattle-area obese and overweight postmenopausal women for a separate new study to assess the impact of vitamin D on weight loss and breast cancer risk factors.


Contact: Kristen Woodward
Fred Hutchinson Cancer Research Center

Related medicine news :

1. Closing Schools Seems to Prevent Flus Spread
2. Losing Baby Weight Cuts Odds of Pregnancy-Linked Diabetes
3. Losing hair at 20 is linked to increased risk of prostate cancer in later life
4. U.S. Nursing Home Closings Hit Poor Neighborhoods Hardest: Study
5. Food Diary a Great Tool for Losing Weight, Expert Says
6. Noise and chemicals: Workers are losing their hearing
7. Losing your religion deemed unhealthy
8. 1 in 5 Parents Missed Work for H1N1 School Closings: Survey
9. Closing the science-to-policy gap in maternal and child health in Africa
10. Revolutionary scale makes losing weight easier than ever
11. Millions Are Losing Their Hearing Unnecessarily; Noise-Induced Hearing Loss Is Always Preventable, Says HearUSA Audiologist
Post Your Comments:
(Date:11/24/2015)... ... November 24, 2015 , ... The Trustees, ... paid entry and parking fees at several of their most popular properties, including ... Barrington in support of REI’s Black Friday #OptOutside Campaign. The Trustees encourage families ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... ... across the United States to support their local poison centers through donations on ... as #GivingTuesday: calls it “a day that inspires people to collaborate in ...
(Date:11/24/2015)... ... 2015 , ... Cold Shoulder , LLC launched their Pro Vest, the latest version of ... goal of $20,000 in under 10 hours. , The campaign, which will ... Loss Vest to the market. , The PRO Vest provides consumers with a less expensive, ...
(Date:11/24/2015)... ... November 24, 2015 , ... American Specialty Health ... have announced their endorsement of the Medical Fitness Network (MFN), a national ... to have the MFN as one of our endorsed organizations,” said ASH Fitness ...
(Date:11/24/2015)... ... November 24, 2015 , ... All her life, Don Peck’s mother wondered if she was a ... might have been. After a 25-year search for information, Don and his aunt discovered ... a last name. Turns out, it was Don’s father who was descended from not ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... 24, 2015 Teledyne DALSA , a Teledyne ... technology, will introduce its CMOS X-Ray detector for mammography ... 29 to December 3, at McCormick Place in ... diagnostic and interventional imaging will be on display in the ... of advanced CMOS X-Ray detectors is the industry benchmark for ...
(Date:11/24/2015)... , Nov. 24, 2015  Enova Illumination is ... of Helsinki, Finland to combine ... are at the cutting edge of medical visualization: Enova ... the United States and Novocam ... Together, they provide the world,s most powerful battery-operated LED ...
(Date:11/24/2015)... Nov. 24, 2015  Freudenberg Medical has developed specialty tubing ... outside of medical facilities. Africa ... care is sparse. Nevertheless, prompt diagnosis is important to treat ... the virus. With the help of a portable mini-lab or ... to village in affected areas and perform rapid testing for ...
Breaking Medicine Technology: