Looking for a link between seizures and migraine after traumatic brain injury i... (personnel and veterans as well as others...)

Looking for a link between seizures and migraine after traumatic brain injury in soldiers

Date:10/12/2011

personnel and veterans, as well as others with TBI. The study will attempt to define the time period when patients are most at risk in order to determine when seizures and CSD occur, and how they interact with each other so that treatment can be delivered when needed. The researchers predict that they will occur together in clusters, during the first few days following injury.

"We will also look into what generates seizures and CSD after brain injury," continues Dudek. "To answer this we will use a variety of imaging and electrical recording tools to dissect the underlying mechanisms within the brain. Only by understanding these mechanisms will we be able to anticipate what damage is likely to occur, and thus prevent it. Our suspicion is that the same mechanisms that lead to repair in the brain also leave the brain in a more excitable state, and we plan to test this possibility."

The ultimate goal, according to Brennan, is to see whether the changes that lead to PTE and PTH after traumatic brain injury can be prevented. "Using the information gained in the first two portions of the study, we will try to prevent these changes with memantine, a medication we identified as a headache preventive, which also prevents CSD and shows promise in enhancing recovery from brain injury," he says. "Our hope is that medications like memantine could be used after TBI, to improve recovery, and to prevent PTE and PTH."

"We owe a great deal to our men and women in uniform," Brennan says. "We hope this work will make a difference in their lives, by improving the care they receive when injured."

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Contact: Dennis Jolley
dennis.jolley@hsc.utah.edu
801-585-7777
University of Utah Health Sciences
Source:Eurekalert

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GOOD

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