Navigation Links
Looking for a link between seizures and migraine after traumatic brain injury in soldiers
Date:10/12/2011

SALT LAKE CITYTraumatic brain injury (TBI) affects many Americans: high school athletes, drivers and passengers in motor vehicle accidents, and victims of domestic violence, to name a few. Some of the most striking effects of brain injury are seen in our soldiers and veterans returning from Iraq and Afghanistan. Two University of Utah researchers are teaming up with the Department of Defense to investigate the long-term effects of TBI in these returning soldiers. K.C. Brennan, M.D., assistant professor in the Department of Neurology, and Edward Dudek, Ph.D., professor and chair of the Department of Physiology, are collaborating on the study.

"Because of advances in protective equipment and armor, more and more of our service personnel are surviving their initial injuries," says Brennan, the study's lead investigator. "However, the long-term consequences of TBI can leave our returning servicemen and women completely incapacitated. Post-traumatic epilepsy (PTE) and post-traumatic headache (PTH) are two of these consequences, and they are probably related: both likely result from increased excitation in the brain."

In PTE, the excitation of the brain results in a seizure, while in PTH, it can cause cortical spreading depression (CSD), an event that can trigger a severe migraine-like headache, according to Dudek. "The fact that many service personnel suffer from both of these conditions at the same time offers a clue that both PTE and PTH may have a common origin in TBI," he says. "Evidence from intensive care units suggests that this is the case: patients after TBI suffer from both seizures and CSD, and these two events seem to interact with one another."

The study funded by the Department of Defense will provide $725,000 over three years to investigate seizures and CSD together to better understand how TBI can set PTE and PTH in motion. The Utah researchers hope understanding this will allow them to develop better treatments for service personnel and veterans, as well as others with TBI. The study will attempt to define the time period when patients are most at risk in order to determine when seizures and CSD occur, and how they interact with each other so that treatment can be delivered when needed. The researchers predict that they will occur together in clusters, during the first few days following injury.

"We will also look into what generates seizures and CSD after brain injury," continues Dudek. "To answer this we will use a variety of imaging and electrical recording tools to dissect the underlying mechanisms within the brain. Only by understanding these mechanisms will we be able to anticipate what damage is likely to occur, and thus prevent it. Our suspicion is that the same mechanisms that lead to repair in the brain also leave the brain in a more excitable state, and we plan to test this possibility."

The ultimate goal, according to Brennan, is to see whether the changes that lead to PTE and PTH after traumatic brain injury can be prevented. "Using the information gained in the first two portions of the study, we will try to prevent these changes with memantine, a medication we identified as a headache preventive, which also prevents CSD and shows promise in enhancing recovery from brain injury," he says. "Our hope is that medications like memantine could be used after TBI, to improve recovery, and to prevent PTE and PTH."

"We owe a great deal to our men and women in uniform," Brennan says. "We hope this work will make a difference in their lives, by improving the care they receive when injured."


'/>"/>

Contact: Dennis Jolley
dennis.jolley@hsc.utah.edu
801-585-7777
University of Utah Health Sciences
Source:Eurekalert

Related medicine news :

1. Ecobumz Diapers are Going Green While Investing in its Own Community and Employing Women Looking to Enter or Re-enter the Workplace
2. Brad Aspin and Health and Wellness Company GBG Now Looking for Leaders Nationwide
3. Arizona Attracts Businesses Looking For Data Center Experts
4. Swanson Health Products is Looking for Tasty, Healthy Culinary Creations
5. With Cosmetic Surgery Becoming More Common, Ft. Lauderdale Doctor says Choosing a Board Certified Plastic Surgeon is Important for Safe, Natural-Looking Results
6. The Real Housewives of New York City Know What Questions to Ask When Looking for a Plastic Surgeon
7. Sirius XM to broadcast Doctor Radio Reports: Understanding Autism -- Looking for Answers
8. Looking older than your age may not be a sign of poor health: Study
9. FDA Looking for Tougher Standards for External Defibrillators
10. FDA Looking at Tougher Standards for External Defibrillators
11. Scientists Discover How HIV Is Transmitted Between Men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... PawPaws ... a new product that was developed to enhance the health of felines. The formula ... , The two main herbs in the PawPaws Cat Kidney Support Supplement ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business ... to $12 an hour by 2020 and then adjusting it yearly to increase at the ... minimum wage, assure the wage floor does not erode again, and make future increases more ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Consumers have taken a more ... placed more emphasis on patient outcomes. ... in the pharmaceutical industry have evolved beyond just ... companies are focusing on becoming more patient-oriented across ... and services that improve health. ...
(Date:6/24/2016)... 24, 2016   Bay Area Lyme Foundation ... Dean Center for Tick Borne Illness , Harvard ... MIT Hacking Medicine, University of California, Berkeley, and ... the five finalists of Lyme Innovation , ... than 100 scientists, clinicians, researchers, entrepreneurs, and investors ...
(Date:6/24/2016)... The Academy of Managed Care Pharmacy (AMCP) ... would allow biopharmaceutical companies to more easily share health ... and coverage decisions, a move that addresses the growing ... The recommendations address restrictions in the sharing of ... label, a prohibition that hinders decision makers from accessing ...
Breaking Medicine Technology: