Navigation Links
'Longevity' protein SIRT1 may ward off precursor to prostate cancer
Date:1/13/2011

r understand SIRT1's role in the development of androgen-responsive tissues, such as the prostate, researchers from Thomas Jefferson University in Philadelphia, worked with the Herbert Irving Comprehensive Cancer Center at Columbia University in New York and the Ottawa Health Research Institute at the University of Ottawa. Dr. Pestell's laboratory carried out a genome-wide microarray, pathway analysis and histology on Sirt1 positive and negative transgenic mice and littermate controls.

The team found that deletion of the Sirt1 gene in mice resulted in PIN formation; features included cellular hyperplasia, increased Ki67 staining, hyperchromatic nuclei and prominent nucleoli, as well as a reduced size in prostate. Gene expression analysis further demonstrated that loss of endogenous Sirt1 inhibited autophagy, which regulates normal gland development.

Dr. Pestell's laboratory was the first to show that the androgen receptor is regulated by the deacetylase enzyme (SIRT1) in cell lines in a tissue culture. "So then we asked the question, 'if you take prostate cancer cell lines, and if the androgen receptor promotes growth, and acetylation promotes growth, does the deacetylase inhibit growth?'" After establishing that it in fact did, researchers applied their mouse model to establish the same relationship on the animal level.

Since the results of the study suggest that drugs that activate Sirt1 could block prostate cancer, Dr. Pestell explains, his team is now working to test various prevention drugs they've screened for testing in human prostate cancer cells.


'/>"/>

Contact: Steve Graff
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New research: Un-growth hormone increases longevity
2. Womens study finds longevity means getting just enough sleep
3. Winning record, team longevity, prime-time games influence NFL TV ratings
4. Aging and longevity tied to specific brain region in mice
5. Scientists Spot Gene Variants That Predict Longevity
6. Sleeping well at 100 years of age: Study searches for the secrets to healthy longevity
7. CogniFit and Longevity Expert Cooperate to Raise Awareness for the Benefits of Brain Fitness
8. Free Anti-Aging Teleseminar Teaches People Key Lifestyle Changes To Maximize Longevity
9. The longevity revolution
10. David Wolfe Hosts 3-Day Longevity Conference: Top Wellness Experts Reveal Tomorrow's Best Natural Health and Nutrition Information Today
11. Doctors Share Longevity Secrets on CBS Broadcasts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2014)... 24, 2014 Global electrophysiology devices ... by 2020, according to a new study by ... cardiac arrhythmias clubbed with growing global geriatric population ... Though still in the budding stage, the electrophysiology ... usage rates in the recent times, with physicians ...
(Date:11/24/2014)... 2014 A new sports massage ... pain-relief service and massage therapy provider, announced it ... This newest sports massage is a ... between traditional sports massage and ESM is that ... very own "reset button,” and ESM can increase ...
(Date:11/24/2014)... Mental health issues affect tens of ... families, ruin careers, and generally destroy lives. , ... suffer,” says Hardy Nutritionals® founder David ... specialized nutritional treatments can reverse these disorders naturally.” ... Matter”, the premiere episode of O2 Media’s new ...
(Date:11/24/2014)... 2014 Dr. Michael Kettel , a ... appeared on NBC to discuss egg freezing as a viable ... trending in the news recently, with new company benefits at ... , “[The companies] see it as a way ... career hot path.” Says Dr. Kettel. , Up until a ...
(Date:11/23/2014)... The report, “Market Snapshot: Aesthetic Lasers ... Asia-Pacific” provides quantitative analysis of the three aesthetic ... body contouring devices, non-invasive body contouring devices and ... data by revenue and volume over the 2006 ... South Korea, Australia and India. It uses data ...
Breaking Medicine News(10 mins):Health News:Electrophysiology Devices Market Worth Forecasted To Reach $6.19 Billion By 2020: Grand View Research, Inc. 2Health News:Electrophysiology Devices Market Worth Forecasted To Reach $6.19 Billion By 2020: Grand View Research, Inc. 3Health News:Electrophysiology Devices Market Worth Forecasted To Reach $6.19 Billion By 2020: Grand View Research, Inc. 4Health News:Sports Massage in London by Massaggi Presents New Technique to Reset Muscles, Rapidly Eliminate Pain 2Health News:Sports Massage in London by Massaggi Presents New Technique to Reset Muscles, Rapidly Eliminate Pain 3Health News:Nutritional Mental Health Treatment Featured on Access Health Airing on Lifetime Television® 2Health News:Nutritional Mental Health Treatment Featured on Access Health Airing on Lifetime Television® 3Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 2Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 3Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 2Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 3Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 4
... in Copenhagen, , MONDAY, Dec. 7 (HealthDay News) -- ... as carbon dioxide endanger people,s health. , The so-called ... administrator of the U.S. Environmental Protection Agency at an ... step by the EPA to regulate greenhouse gases under ...
... , HOUSTON Dec. 7 Dr. Victor ... room physician and medical entrepreneur in Houston, as a father and ... 52, Victor suffered cardiac arrest as a result of an undetected ... save lives as an organ and tissue donor. Dr. Miranda is ...
... study shows that people who have been infected with ... kidneys for years after initial infection, potentially leading to ... 1 issue of The Journal of Infectious Diseases ... Spread by infected mosquitoes, West Nile virus was first ...
... SOUTH PORTLAND, Maine, Dec. 7 Times are tough for a ... living on fixed incomes, times are even tougher. , But ... and Blue Shield in Maine and developed by the National Council ... Supplemental Nutrition Assistance Program (SNAP), formerly the federal food stamp program, ...
... 7 "You can,t teach an old dog new tricks," it,s ... about pets continue to be passed down from generation to generation. ... pet owners believe them and act on them," says Mark Nunez, ... check with your veterinarian to find out if a commonly held ...
... PAUL, Minn., Dec. 7 Securian,s IncomeToday! single ... on the CANNEX SPIA Exchange. , IncomeToday! debuted ... the Advance Withdrawal Benefit. This feature allows clients to take ... income stream, making IncomeToday! a fixed annuity that ...
Cached Medicine News:Health News:EPA: Greenhouse Gases Hazardous to Your Health 2Health News:EPA: Greenhouse Gases Hazardous to Your Health 3Health News:The Dignity Memorial(R) Network Honors Four Individuals Who Gave the Gift of Life Through Organ and Tissue Donation 2Health News:The Dignity Memorial(R) Network Honors Four Individuals Who Gave the Gift of Life Through Organ and Tissue Donation 3Health News:West Nile virus infection may persist in kidneys years after initial infection 2Health News:West Nile virus infection may persist in kidneys years after initial infection 3Health News:Anthem Blue Cross and Blue Shield in Maine and National Council on Aging Provide Vital Benefits Information to Economically Challenged Older Adults 2Health News:Some Myths About Dogs and Cats Are Not Only False - They're Dangerous! 2Health News:IncomeToday! Securian's Minnesota Life/SPIA Product Added to CANNEX Exchange 2
(Date:11/24/2014)... YORK , Nov. 24, 2014  Relmada Therapeutics, ... for the treatment of chronic pain, announced today that ... to present at the LD MICRO "MAIN Event" Micro-Cap ... will be held at the Luxe Sunset Bel Air ... Los Angeles, California . ...
(Date:11/24/2014)... Theater, LLC, announced today that their technology will be ... Europe,s first simulation center, The ... Planner (SRP) and the Surgical Navigation Advanced Platform (SNAP) ... navigation and augmented reality capabilities in the operating room ... Department of Neurosurgery at Mount Sinai Health System in ...
(Date:11/24/2014)... novembre 2014  Surgical Theater LLC ha ... esposta durante l,apertura in data 24 novembre ... la Fondazione IRCCS Istituto Neurologico Nazionale "C. ... (strumento di pianificazione chirurgica) e Surgical Navigation ... avanzata) saranno presentati in occasione dell,evento dedicato ...
Breaking Medicine Technology:Relmada Therapeutics To Present At LD MICRO Conference 2Surgical Theater's Technology to be Showcased at the Opening of the Besta NeuroSim Center in Milan, Italy 2Surgical Theater's Technology to be Showcased at the Opening of the Besta NeuroSim Center in Milan, Italy 3La tecnologia di Surgical Theater in mostra in Italia all'apertura del centro Besta NeuroSim di Milano 2La tecnologia di Surgical Theater in mostra in Italia all'apertura del centro Besta NeuroSim di Milano 3La tecnologia di Surgical Theater in mostra in Italia all'apertura del centro Besta NeuroSim di Milano 4
... and TORONTO, Feb. 27, 2012 Generex Biotechnology Corporation ... President of Generex subsidiary Antigen Express, Inc., will give ... be held in Boston, MA February 27-29.  The presentation, ... the Role of Th cells," will be given Wednesday, ...
... WHAT: Gearing up for its 2012 multi-city tour, the first stop ... with the Coconut Grove Chamber of Commerce, along with input ... has listed the "Top 25 Sights to See" in Miami ... – tourists and Miami locals alike – to vote on ...
Cached Medicine Technology:Generex Subsidiary Antigen Express to Present at Prestigious Cancer Immunotherapy Summit 2Generex Subsidiary Antigen Express to Present at Prestigious Cancer Immunotherapy Summit 3Generex Subsidiary Antigen Express to Present at Prestigious Cancer Immunotherapy Summit 4Transitions Optical Kicks-Off 2012 Multi-City "Sightseeing City Tour" with Voting Contest for "Top 10 Sights to See" in Miami 2
... a cast from an arm or leg can ... cut or burned by the cast saw blade. ... remove any cast with confidence. This innovative, cut-resistant ... burns from the cast saw and can be ...
... bypass grafting or creation of a vascular ... tunnel is of the utmost importance in ... answer for those seeking a high-precision tunneling ... the risk of twisting or kinking for ...
... In pediatric cardiac surgery, modified Blalock-Taussig ... prior to total correction. GORE-TEX Vascular Grafts ... of surgeons worldwide for use as shunts ... offer such benefits as ease of implantation ...
... have met the challenges of the most ... Recognized for exceptional performance and quality, they ... worldwide. These grafts require no preclotting, resist ... assure utmost thrombectomy safety. The Gore vascular ...
Medicine Products: