Navigation Links
'Longevity' protein SIRT1 may ward off precursor to prostate cancer
Date:1/13/2011

PHILADELPHIAResearchers from the Kimmel Cancer Center at Jefferson and two other institutions have discovered new evidence that suggests the "longevity" protein SIRT1, known for its life-spanning effects in different species, can inhibit the development of a known precursor to prostate cancer, prostatic intraepithelial neoplasia (PIN).

Results from the study could lead to new cancer prevention drugs that could not only block prostate cancer but promote longevity.

The study, published in the February 1 issue of Cancer Research, found that deletion of the Sirt1 gene in mice resulted in PIN lesion formation associated with reduced autophagy, which is the necessary degradation of a cell's own components and most likely essential for tumor suppression.

"Prostate cancer is one of the malignancies that has a very direct relationship to aging," says Richard G. Pestell, M.D., Ph.D., Director, Kimmel Cancer Center and Chairman of Cancer Biology at Thomas Jefferson University. "And these results provide a direct link for the first time between the onset of prostate cancer and the Sirt1 gene that regulate aging."

The results suggest that the Sirt1 gene promotes autophagy and further highlight the role of the protein SIRT1 (the human homologue of the yeast Silent Information Regulator 2 (Sir2) gene) as a tumor suppressor in the prostate. According to Dr. Pestell, "if you inactivate this gene, then you get the prostate cancer precursor, known as PIN. So it tells you that this 'longevity' gene is normally blocking prostate cancer."

Previous studies have found that SIRT1which was discovered about 15 years ago and found to have various life-spanning effects in yeasts, worms, mice and possibly humanscan both inhibit tumor growth in certain cancers as well as promote it by inactivating the tumor suppressor p53, but its role in regulating prostate gland development and androgen signaling in vivo was unknown.

To bette
'/>"/>

Contact: Steve Graff
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New research: Un-growth hormone increases longevity
2. Womens study finds longevity means getting just enough sleep
3. Winning record, team longevity, prime-time games influence NFL TV ratings
4. Aging and longevity tied to specific brain region in mice
5. Scientists Spot Gene Variants That Predict Longevity
6. Sleeping well at 100 years of age: Study searches for the secrets to healthy longevity
7. CogniFit and Longevity Expert Cooperate to Raise Awareness for the Benefits of Brain Fitness
8. Free Anti-Aging Teleseminar Teaches People Key Lifestyle Changes To Maximize Longevity
9. The longevity revolution
10. David Wolfe Hosts 3-Day Longevity Conference: Top Wellness Experts Reveal Tomorrow's Best Natural Health and Nutrition Information Today
11. Doctors Share Longevity Secrets on CBS Broadcasts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... 14, 2014 Vaginal Mesh lawsuit ... seven different pelvic mesh manufacturers in the U.S. District ... Schulte LLC. The federal complaints are pending against pelvic ... American Medical Systems (MDL No. 2325), and C.R. Bard, ... are 58,262 Vaginal Mesh lawsuit claims pending, according to ...
(Date:7/14/2014)... COPENHAGEN Participation in activities that promote mental ... may help protect against the development of Alzheimer,s ... new research reported today at the Alzheimer,s Association ... , Research reported at AAIC 2014 also showed ... post-traumatic stress disorder (PTSD) may increase dementia ...
(Date:7/14/2014)... 14, 2014 Love Digits LLC has ... Love Digits. The App brings ancient astrology to the ... quantify their compatibility using a five-star rating system. By ... can instantaneously test their compatibility for love and marriage ... The app’s five-star rating system generates a weighted average ...
(Date:7/14/2014)... CT (PRWEB) July 14, 2014 Summer is ... vacations, camping, days at the beach, swimming and other outdoor ... everyone to be safe, happy and healthy all summer long. ... a list of the three must-have custom imprinted products everyone ... summer essential is of course sunblock. Sunscreen helps ...
(Date:7/14/2014)... 14, 2014 Crystal Dental has ... Sacramento. The announcement has been made via LAD Solutions in ... the announcement has been made in order to draw in ... the Sacramento area. , Crystal Dental offers a variety of ... services offered by Crystal Dental include cosmetic dentistry procedures such ...
Breaking Medicine News(10 mins):Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 2Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 3Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 4Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 5Health News:Potential Alzheimer's disease risk factor and risk reduction strategies become clearer 2Health News:Potential Alzheimer's disease risk factor and risk reduction strategies become clearer 3Health News:Potential Alzheimer's disease risk factor and risk reduction strategies become clearer 4Health News:Potential Alzheimer's disease risk factor and risk reduction strategies become clearer 5Health News:Potential Alzheimer's disease risk factor and risk reduction strategies become clearer 6Health News:Love Digits, Numerical Approach to Modern Love, Now Available on iTunes 2Health News:Love Digits, Numerical Approach to Modern Love, Now Available on iTunes 3Health News:Why These Three Summer Essentials from 4AllPromos Can Improve Summer 2Health News:Crystal Dental Announces the Opening of New Office Location in Sacramento 2
... How people walk, jump and run and how their knees ... predicting years or even decades in advance whether they will ... of all Americans by the time they reach the age ... gait, leap, stride or scan and tell you definitively whether ...
... News) -- People whose parents had a drinking problem are ... stress, a new study says. Swedish researchers divided 58 ... a family history of alcohol abuse. Both groups were placed ... in public) and then allowed to drink. People who ...
... up just got more complicated. Thomas Jefferson University ... receptor for a major insect molting hormone doesn,t activate and ... genes, and it is out-competed by a heme-binding receptor to ... in the fruit fly. For the last 20 years, ...
... U.S. Food and Drug Administration and the National Institutes ... of tobacco users to monitor and assess the behavioral ... The initiative, called the Tobacco Control Act National Longitudinal ... collaboration on tobacco regulatory research since Congress granted FDA ...
... of open angle glaucoma important so that treatment can be ... prevent or avoid further vision loss. Writing in a forthcoming ... Informatics , researchers in the US have analyzed and ranked ... patients can be screened at an earlier stage if they ...
... News) -- ,Anemia increases the risk of death and complications ... heart operations, a new study says. It was known ... but anemia,s impact on non-cardiac surgical outcomes wasn,t clear. People ... For the new study, researchers analyzed data from more than ...
Cached Medicine News:Health News:$6.3 million center at UCSF and UC Davis seeks ways to diagnose and prevent osteoarthritis 2Health News:$6.3 million center at UCSF and UC Davis seeks ways to diagnose and prevent osteoarthritis 3Health News:Nuclear receptors battle it out during metamorphosis in new fruit fly model 2Health News:FDA and NIH announce joint study on tobacco use and risk perceptions 2Health News:Detecting glaucoma before it blinds 2Health News:Anemia Could Add to Surgical Risks 2
(Date:7/11/2014)... July 11, 2014 /PRNewswire-iReach/ -- VAPETEK™, Inc. has ... solution for use in portable vaporizers, which contains ... ingredients in cannabis, cannabidiol offers consumers a THC-free ... and other vaporizer technology. Photo - ... contains 483 different compounds which are currently known, ...
(Date:7/11/2014)... 2014 Research and Markets has ... Medical X-ray Film Industry Report 2014" report to ... Global And Chinese Medical X-Ray Film Industry ... the current state of the Global medical X-ray film ... The report provides a basic overview of the industry ...
(Date:7/11/2014)... July 11, 2014  Australian drug delivery company, Phosphagenics ... has raised A$19.3 million via a placement of A$16.3 ... , the U.S., Asia and ... a share purchase plan (SPP) to be offered to ... made in two tranches. "This capital raising ...
Breaking Medicine Technology:VAPETEK Releases CBD-Infused eLiquid For The Consumer Market 2Global and Chinese Medical X-ray Film Industry Report 2014 2Phosphagenics' A$19.3 million Capital Raising 2Phosphagenics' A$19.3 million Capital Raising 3
... Sept. 28 Regeneron Pharmaceuticals, Inc. (Nasdaq: ... on the topic "Eye Diseases: Novel Therapies for Wet ... Citi,s 5th Annual Biotech Day on Tuesday, October 5, ... 8:00 a.m. Eastern Time and may be accessed through ...
... Inc. today announced that the U.S. Patent and ... another key patent application, "Mechanical Method and Apparatus ... matter covering the method of the INSORB Skin ... has now sold over 500,000 INSORB® Absorbable Skin ...
Cached Medicine Technology:Incisive Surgical Issued Notice of Allowance for Key Absorbable Skin Stapler Patent 2Incisive Surgical Issued Notice of Allowance for Key Absorbable Skin Stapler Patent 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: