Navigation Links
Longest and largest study of insulin pumps to treat type 1 diabetes in children shows they control blood sugar more effectively and with fewer complications than injections
Date:8/18/2013

The longest and largest study of the effectiveness of insulin pumps to treat type 1 diabetes in children has shown that the pumps are more effective at controlling blood sugar than insulin injections and cause fewer complications. The research is published in Diabetologia, the journal of the European Association for the Study of Diabetes, and is by Associate Professor Elizabeth Davis, Princess Margaret Hospital for Children, Perth, WA, Australia and colleagues.

The increasing use of insulin pump therapy over the last 15 years, particularly in children, has been driven by improvements in pump technology, the availability of insulin analogues, plus factors such as the results of the Diabetes Control and Complications Trial which established the benefits offered by improved blood sugar control. Despite this increased use, the outcomes of pump therapy continue to be debated. However there has been inadequate research into the long term effects of pump therapy in children, with many studies too short in duration or not recruiting enough patients.

In this study, a total of 345 patients on pump therapy were matched to controls on injections, with a mean age 11 years (range 2-19 years), with a mean duration of diabetes at the start of pump therapy of 4.1 years (range 6 months to 15.5 years) and a follow up of 3.5 years (range 0-10.5 years). The mean HbA1c reduction (a standard method for measuring blood glucose control) in the pump cohort was 0.6% (6.6 mmol/mol). This improved HbA1c remained significant until seven years of follow up (at which point the numbers in the study were too small to analyse the results with statistical confidence). Both groups started with the same HbA1c and max difference was 1% difference at 6 yrs: 7.6 % in the pump group and 8.6 % in the non-pump group.

Pump therapy reduced episodes of severe hypoglycaemia (dangerously low blood glucose) from 14.7 to 7.2 events per 100 patients per year. In contrast, severe hypoglycaemia increased in the non-pump cohort over the same period from 6.8 to 10.2 events per 100 patients per year (probably due to random variation). The rate of admission for diabetic ketoacidosis (a shortage of insulin causing the body to switch to burning fats and producing acidic ketone molecules which cause complications and symptoms, a frequent complication in children with T1DM) was lower in the pump cohort than in the non-pump cohort (2.3 vs 4.7 per 100 patients per year) during follow up.

Of the 345 patients on pump therapy, 38 ceased pump therapy during the course of the study; 6 of these were in the first year of treatment, 7 in the second year of treatment, 10 in the third year of treatment with the remainder ceasing treatment after at least 3 sequential years on pump therapy. Some children stop because they become tired of the extra attention needed to manage pump and/or concerned about the physical sight of the pump. Other children sometimes take a temporary 'pump holiday' and then recommence pump use.

Dr Davis concludes: "This is the largest study of insulin pump use in children. It also has the longest follow up period of any study of insulin pump therapy in children. Our data confirm that insulin pump therapy provides an improvement in glycaemic control which is sustained for at least seven years... Children and adolescents with poor control had the greatest reduction in HbA1c with insulin pump therapy...Although this is not a randomised trial, it is 'real life' experience in a large population based sample over a prolonged time period and as such provides important information."


'/>"/>

Contact: Elizabeth Davis
Elizabeth.Davis@health.wa.gov.au
61-414-930-102
Diabetologia
Source:Eurekalert

Related medicine news :

1. National Daylight Appreciation Day and Solatube International Celebrate the Benefits of Sunlight on the Longest Day of the Year
2. GBP Releases Its Largest Sunday River Property Offering Ever
3. Bodybuilding.com and Image Sports Partner for the Largest Online Launch
4. House of Brides Warehouse Sale Expected to be Largest Ever
5. FlipOver.org Mobilizes Social Entrepreneurship Through Crowdsourcing Agreement with Indonesia’s Largest Youth Organization
6. UIC to serve as Chicago site for largest-ever US study of Hispanic/Latino health
7. CyraCom Ranked Amongst the World’s Largest Language Services Providers
8. North America Leads the Largest Market Share of the Bioinformatics Market Says New Research Report by MarketsandMarkets
9. Challenge of Champions, the Largest Martial Arts Tournament of its Kind in the World, to be Held in Edison, New Jersey
10. Time and Gems Offers Buyers the Largest Collection of Rolex Watches Yet
11. CaringBridge Founder Mehring Reveals Inspiration For World's Largest Support Network In New Book
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... New York City based oral and maxillofacial surgeon Dr. ... very effective way to treat obstructive sleep apnea. Dr. Jamali is proud to offer this ... procedure that involves one or both jaw bones. This surgery is performed to correct the ...
(Date:4/29/2016)... ... 29, 2016 , ... For those who skip meals occasionally (which is pretty ... among the many new lifestyle diet tips offered by nutritionists Pam Bonney and Priya ... Water® radio show. Bonny and Lawrence noted that because proper nutrition, including water, provides ...
(Date:4/29/2016)... ... April 29, 2016 , ... Innovations with Ed Begley Jr., ... episode, airing third quarter 2016 via Discovery Channel. Dates and show times TBA. ... Products, located in Greenwood, Wisconsin applies product research and development and continuous technological ...
(Date:4/29/2016)... ... April 29, 2016 , ... CURE Media Group ... patients with cancer, today announced that Lynne Malestic, RN, of Eisenhower Lucy Curci ... Extraordinary Healer® for Oncology Nursing , which honors nurses who have dedicated their ...
(Date:4/29/2016)... Rafael, CA (PRWEB) , ... April 29, 2016 , ... ... week long softball camp from July 24th – 27th for girls aged 10-18. All ... camp is held at the beautiful Clark V. Whited Complex, one of the finest ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016 ... George Phillips und Stephen ...    ArisGlobal®, ein führender Anbieter ... gab heute bekannt, dass neue Führungskräfte zum ... gestoßen sind, die vielfältige Erfahrungen mitbringen.  Dies ...
(Date:4/28/2016)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) ( ... of oral drug delivery systems, announced today that the Company ... Joseph Gunnar & Co. LLC, taking place on ... Nadav Kidron , CEO of Oramed, will present a ...   PIONEERS 2016, presented by Joseph Gunnar ...
(Date:4/27/2016)... Inc. (Nasdaq: HOLX ) announced today ... quarter ended March 26, 2016.  GAAP diluted earnings ... non-GAAP diluted EPS of $0.47 increased 14.6%.  Revenue ... basis, and 6.3% on a constant currency basis.  ... highlighted by 14.6% growth in non-GAAP EPS," said ...
Breaking Medicine Technology: