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Longer life expectancy, aging population necessitate new strategies for prostate cancer care
Date:12/4/2012

essaging chain that tells prostate cancer to grow. CU Cancer Center researchers have played an important role in the clinical development of both of these drugs.

Researchers are also looking for additional, molecular drivers of prostate cancer, perhaps for example insulin growth factor.

"We're also exploring the use of targeted kinase inhibitors," Kessler says. For example, the drug known as XL184 by Exelixis is currently in clinical trials to target MET and VEGF, "and appears to show effect against bone lesions, the most common location of prostate cancer metastasis," Kessler says.

"Another promising strategy to treat metastatic prostate cancer is immunotherapy," Kessler says. In immunotherapy, drugs, devices or treatments are used to sensitize the body's immune system to attack cancer cells boosting the body's ability to clear itself of cancer. For example, the drug Sipuleucel-T was approved by the FDA in 2010 for treatment of metastatic prostate cancer "but it requires blood to be removed, treated, and reinfused," Kessler says a procedure that can only be accomplished by shipping the patient's blood to facilities in other cities before reinfusing it here. Second generation prostate cancer immunotherapies including Prostvac are in development or clinical trials, including an open trial at the CU Cancer Center.

Finally, researchers are exploring ultra-precise targeting of radiation that rides along with drugs that attach to bone metastases and affects only the tumor cells in the immediate areas of attachment. "One of these drugs is Alpharadin," Kessler says, "which goes only shallowly into bone and so targets lesions without stopping the production of bone marrow."

"There has been a major shift in the acceptance of these drugs," Kessler says. "We're learning to reach for them sooner and more frequently in place of traditional chemotherapies."

This shift means that just as boomers pass age 65 the most commo
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Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

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