Navigation Links
Longer Antiviral Therapy Reduces Lung Transplant Complications
Date:6/14/2010

Study finds 12-month course of valganciclover wards off dangerous CMV infections

MONDAY, June 14 (HealthDay News) -- Extended antiviral treatment after a lung transplant may help prevent dangerous complications and organ rejection, a new study from Duke University Medical Center shows.

A common cause of infection in lung transplant recipients is cytomegalovirus (CMV), which often causes mild effects but can be life-threatening for transplant patients. Standard preventive therapy involves taking the drug valganciclovir (Valcyte) for up to three months. But even with this treatment, most lung transplant patients develop CMV infections within a year.

The Duke study included 136 patients who completed three months of oral valganciclovir and then received either an additional nine months of placebo (66 patients) or an additional nine months of oral valganciclovir (70 patients). Since it was a double-blind, placebo-controlled randomized study, researchers compared two groups of randomly selected patients at 11 different centers (one group of which received the additional medication and a control group that received the placebo, with neither the researchers nor the participants knowing who was in the control group).

Researchers found that CMV infection occurred in 10 percent of the extended treatment group, compared to 64 percent of the placebo group. Pneumonia caused by CMV virus occurred in 4 percent of the extended-treatment group and in 32 percent of the placebo group.

"We found that 12 months of oral valganciclovir was extremely effective and led to a dramatic reduction in the rate of CMV infection and disease," Dr. Scott Palmer, scientific director of the Lung Transplant Program at Duke University Medical Center, said in a university news release.

Potential side effects of valganciclovir include nausea, diarrhea, anemia and other blood disorders, retinal detachment, headache, fever, vomiting, mental changes and other problems. However, the study "showed that there was no increased or added toxicity with the extended course of treatment," Palmer said.

"In addition, the study examined viral resistance mutations and demonstrated that extended therapy did not lead to increased drug resistance, a potential concern with longer courses of treatment," Palmer added.

The study, published in the June 15 issue of the Annals of Internal Medicine, was funded by Roche Pharmaceuticals, which makes Valcyte.

More information

The American Academy of Family Physicians has more about CMV.



-- Robert Preidt



SOURCE: Duke Medicine, June 14, 2010. news release.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Using Nicotine Patch Longer Boosts Efforts to Quit
2. Sedation Linked to Longer Stay in ICU
3. Zambian study finds longer breastfeeding best for HIV-infected mothers
4. Pet Health Insurance Grows as Pets Live Longer and Healthier Lives
5. Marijuana Use No Longer Dropping Among U.S. Teens
6. Looking Younger Than Your Age May Mean Longer Life
7. Military children face more emotional challenges as parental deployments grow longer, study finds
8. Glaucoma Drugs May Play Role in Longer Life
9. Biological clock could be a key to better health, longer life
10. Big Smiles, Longer Lives?
11. Perhaps a longer lifespan, certainly a longer health span
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Longer Antiviral Therapy Reduces Lung Transplant Complications
(Date:5/31/2016)... ... , ... Splashtop Inc., the worldwide leader in high performance cross-screen access, ... leading provider of secure mobile remote access solution for Japan enterprises. , ... solution. Splashtop for CACHATTO will be available as an integrated add-on secure ...
(Date:5/31/2016)... ... , ... DDL, Inc. announced today it has expanded the scope of its ... 594-1 and ISO 594-2 testing for conical (Luer) fittings. , A conical Luer ... devices (e.g. a syringe and hypodermic needle) that carry small volumes of fluids. There ...
(Date:5/31/2016)... ... 2016 , ... Like jewels in a crown, the multiple awards presented to ... to Ontario’s leading day spa and one of Canada’s few accredited 5 Star Spas! ... concept to combine spa services with hair and beauty services and has ...
(Date:5/31/2016)... ... May 31, 2016 , ... The Orthopaedic Research and Education ... , David G. Lewallen, MD, began his term as president in March, succeeding ... Parks, MD, is OREF’s new president-elect. Richard F. Kyle, MD, will serve as chair, ...
(Date:5/31/2016)... Aviv (PRWEB) , ... May 31, 2016 , ... ... the May 4, 2016 Cool Vendors in Security Infrastructure Protection report by Gartner1 ... and publishes a series of research reports evaluating these innovative vendors and their ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... LONDON , May 30, 2016 ... to eliminate viral hepatitis by 2030. At the 69 th ... first ever Global Viral Hepatitis Strategy, signalling the greatest global ... sets a goal of eliminating hepatitis B and C by ... which, if reached, will reduce annual deaths by 65% and ...
(Date:5/30/2016)... DUBAI , May 30, 2016 ... parents of premature babies to seek an eye examination ... avoid blinding condition     Moorfields Eye ... Hospital in London , has identified premature babies ... vision problems, because of their particular vulnerability to retinopathy of prematurity ...
(Date:5/27/2016)... 2016 According to the 2016 ... driving ambulatory blood pressure monitoring system market growth. With ... ability to respond to different pressure rates, leading to ... to various cardiovascular disorders such as heart failure, stroke, ... are growing in prevalence each year. WHO estimates that ...
Breaking Medicine Technology: