Navigation Links
Long-term study shows that kidney transplants are faring better than previously reported
Date:4/7/2011

ROCHESTER, Minn. -- A new study from Mayo Clinic (http://www.mayoclinic.com/), the largest long-term study of kidney transplant recipients published to date, demonstrates that progressive damage to kidney transplants may be less common and less severe than previously reported.

The study, involving 797 patients transplanted between 1998 and 2004 and followed for at least five years, shows that 87 percent of patients have mild or no signs of progressive scar damage to the transplanted organ when biopsied at one year after transplant. This number decreases only slightly at the five-year mark (83 percent). In contrast, studies of patients transplanted in the early 1990s suggested that a majority of transplanted kidneys were affected by progressive scarring that ultimately led to failure of the transplant.

"These results are significant and encouraging for everyone who is concerned about long-term survival for kidney transplant patients," says Mark Stegall, M.D., (http://www.mayoclinic.org/bio/12971332.html) transplant surgeon at Mayo Clinic. "Our results suggest that transplanted kidneys may be doing better than reports from prior eras have indicated."

The Mayo Clinic study is published in the April 2011 issue of the American Journal of Transplantation (http://onlinelibrary.wiley.com/doi/10.1111/j.1600-6143.2010.03312.x/abstract).

Patients in the study received a kidney transplant at Mayo Clinic in Rochester, Minn. As part of normal follow-up care, the patients were encouraged to return for checkups at four months, one year, two years and five years post-transplant. Kidney biopsies, as well as renal function measures and other tests, were routinely taken at these milestones. While fewer patients returned for checkups over time, a subgroup of 296 patients underwent biopsies at the one-year and five-year mark, allowing the researchers the opportunity to directly monitor changes in the kidney over time.

Using this information, researchers found that 47 percent of patients had minimal fibrosis (scarring) and 40 percent had mild fibrosis (87 percent total) one year after transplant. At five years after transplant, the numbers changed slightly, with 38 percent showing minimal fibrosis and 45 percent showing mild fibrosis (83 percent total). Results were similar for kidneys transplanted from living and deceased donors.

Dr. Stegall explains that minimal or mild fibrosis does not interfere significantly with kidney function. However, the development of severe scarring interferes with the kidney's ability to function and may result in the patient needing to start dialysis or undergo a second transplant.

Key to the study was that biopsies were routinely taken at post-transplant checkups. "That information allowed us to better understand what happens over those five years," says Walter Park, Mayo Clinic associate in the Department of Surgery (http://www.mayoclinic.org/surgery/) who analyzed the study data. "We now know that when patients have mild fibrosis at one year, it doesn't mean that it will progress to severe fibrosis at five years."

The research team will continue its work to learn more about why some kidneys still develop problems and how to avoid them. They also are interested in determining if kidneys that are doing well at five years are still prone to injury later.


'/>"/>

Contact: Ginger Plumbo
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Treatment for depression a long-term solution
2. Long-Term Ecstasy Users at Risk for Brain Damage, Study Warns
3. Study shows that modern surgery for scoliosis has good long-term outcomes
4. Bariatric surgery reduces long-term cardiovascular risk in diabetes patients
5. Long-term study: Robot-assisted prostate surgery is safe
6. Tamoxifen May Offer Long-Term Heart, Cancer Protection
7. Researchers find new mechanism behind the formation and maintenance of long-term memories
8. Herceptin May Boost Long-Term Survival After Aggressive Breast Cancer
9. Rituximab and fludarabine produce long-term remissions in CLL
10. Study links long-term use of osteoporosis drugs to unusual fractures
11. Facial Surgery May Offer Long-Term Migraine Relief for Some
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of ... too high can result in disappointment, perhaps even self-loathing. However, those who set the ... Research from PsychTests.com reveals that behind the tendency to set low expectations ...
(Date:6/24/2016)... ... , ... Marcy was in a crisis. Her son James, eight, was out of control. Prone ... physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If ... at my other children and say he was going to kill them. If we ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is ... Road To Recovery® program to drive cancer patients to and from their cancer treatments. ... the highest quality of life and ongoing independence. Getting to and from medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty ... Barry M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... and the most handsome men, look naturally attractive. Plastic surgery should be invisible.” ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) ... held on June 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, ... dedicated to helping service members that have been wounded in battle and their families. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research and ... Global Market - Forecast to 2022" report to their ... treatment method for the patients with kidney failure, it replaces ... fluid from the patient,s blood and thus the treatment helps ... and chloride in balance. Increasing number of ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Medical Market Analysis 2016 - Forecast to 2022" report ... The report contains up to date financial data derived from ... of major trends with potential impact on the market during ... market segmentation which comprises of sub markets, regional and country ...
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
Breaking Medicine Technology: