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Long-term study shows that kidney transplants are faring better than previously reported
Date:4/7/2011

ROCHESTER, Minn. -- A new study from Mayo Clinic (http://www.mayoclinic.com/), the largest long-term study of kidney transplant recipients published to date, demonstrates that progressive damage to kidney transplants may be less common and less severe than previously reported.

The study, involving 797 patients transplanted between 1998 and 2004 and followed for at least five years, shows that 87 percent of patients have mild or no signs of progressive scar damage to the transplanted organ when biopsied at one year after transplant. This number decreases only slightly at the five-year mark (83 percent). In contrast, studies of patients transplanted in the early 1990s suggested that a majority of transplanted kidneys were affected by progressive scarring that ultimately led to failure of the transplant.

"These results are significant and encouraging for everyone who is concerned about long-term survival for kidney transplant patients," says Mark Stegall, M.D., (http://www.mayoclinic.org/bio/12971332.html) transplant surgeon at Mayo Clinic. "Our results suggest that transplanted kidneys may be doing better than reports from prior eras have indicated."

The Mayo Clinic study is published in the April 2011 issue of the American Journal of Transplantation (http://onlinelibrary.wiley.com/doi/10.1111/j.1600-6143.2010.03312.x/abstract).

Patients in the study received a kidney transplant at Mayo Clinic in Rochester, Minn. As part of normal follow-up care, the patients were encouraged to return for checkups at four months, one year, two years and five years post-transplant. Kidney biopsies, as well as renal function measures and other tests, were routinely taken at these milestones. While fewer patients returned for checkups over time, a
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Contact: Ginger Plumbo
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

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