Navigation Links
Long-term study shows low oxygen levels in prostate tumors can predict recurrence

ORLANDO (May 15, 2009)Fox Chase Cancer Center researchers have discovered that low-oxygen regions in prostate tumors can be used to predict a rise in prostate-specific antigen (PSA) levels, a marker of tumor recurrence in prostate cancer. The long-term study results will be presented at the 2009 American Society of Clinical Oncology annual meeting in Orlando, FL.

Aruna Turaka, M.D., radiation oncology fellow at Fox Chase and lead author on the study, explained that low oxygen, or hypoxia, in tumors is a well-known risk factor for radiation resistance in solid tumors. Between 2000 and 2002, Fox Chase research colleagues published six research papers detailing the link between tumor hypoxia, radioresistance, and the risk of increased PSA levels. But mean follow-up at the time of those studies was 19 months, she said. The current study reinforces those preliminary findings with more "mature" data and a median follow-up of 8 years.

In the current study, Turaka and her colleagues used a custom-built probe to monitor the amount of oxygen that prostate tumors and non-cancerous muscle tissue were receiving. They used this probe on 57 patients with low or intermediate risk of cancer just before the patients received a form of localized radiation therapy. The researchers then tracked the patients over time, looking for a correlation between the amount of oxygen levels in the prostate tumor relative to the muscle tissue at the time of therapy and later looked at the increase in PSA levels.

Eight of the 57 patients experienced an increase in PSA levels following prostate cancer treatment, defined as an increase of 2 ng/mL above the lowest PSA reading following brachytherapy. Overall, average muscle oxygenation was 12.5-times higher than that of the tumor (30 mm Hg vs 2.4 mm Hg). Using a statistical model that accounted for such risk factors as tumor grade, PSA level, and tumor size, the team determined that hypoxia was a significant independent predictor of an increase in PSA levels.

In other words, even after accounting for PSA value, Gleason score, tumor size, age, and other prostate cancer risk factors, tumor hypoxia alone could predict the likelihood of increased PSA levels, and potentially tumor recurrence.

"Now", Turaka said, "the goal is to apply the results to the clinic". That, she said, requires a two-pronged approach: developing noninvasive screening methods to identify hypoxic tumors, and more potent anticancer weapons to target them.

"We already knew that there are hypoxic regions within cancers," she said. "The future goal is to interpolate that to relate to the expression of molecular markers [such as hypoxia-inducible factor-1-alpha] and attack those tumors with dose escalation radiation oncology strategies and targeted agents."


Contact: Diana Quattrone
Fox Chase Cancer Center

Related medicine news :

1. Cocaine Spurs Long-Term Change in Brain Chemistry
2. Implanted Defibrillators Boost Long-Term Survival
3. John Hancock Selects CHCS Services to Manage Long-Term Care Insurance Provider Discount and Caregiver Programs
4. AAHSA Joins Sixty Aging and Disability Groups to Fight for Long-Term Services and Supports in Health Care Reform
5. Heinz Family Philanthropies ( Release New Facts About Cards, Highlighting Questions Families Should Ask About Long-Term Care -- 10 Questions to Answer... (
6. AAHSA President Discusses Long-Term Care Solution at SCAN Foundation/Health Affairs Conference
7. Aging Advocate Named President of Marylands Leading Long-Term Care Association
8. Despite the Economic Downturn, Long-Term Growth Potential in the US Dental Biomaterial Market Remains Robust
9. Community Approach Necessary For Affordable Long-Term Care, Says NCB Capital Impact
10. Ochsner and Australia Partner for Long-Term Solution to Physician Shortages
11. First 10-year follow-up shows that treatment with AVONEX leads to long-term benefits in early multiple sclerosis patients
Post Your Comments:
(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... ... 2016 , ... Austin residents seeking Mohs surgery services, can now turn to ... Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to ... fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the ... Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , “We ... new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and ... their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took ... the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may suffer ... unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid ... healthy coping following a traumatic event. , Trauma sufferers tend to feel a range ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 , ... on Thursday, July 7, 2016 , , , , LOCATION: ... , , , , EXPERT PANELISTS:  , , , ... Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and ... The global pharmaceutical industry is witnessing an exceptional era. ...
(Date:6/23/2016)... BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia ... the company,s second affiliate in Latin America . ... ... Farma Colombia ... ...
(Date:6/23/2016)... , June 23, 2016  Guerbet announced today ... Inc.,s Supplier Horizon Award . One ... Guerbet was recognized for its support of Premier members ... through clinical excellence, and commitment to lower costs. ... receive this recognition of our outstanding customer service from ...
Breaking Medicine Technology: