Navigation Links
Long-term study shows low oxygen levels in prostate tumors can predict recurrence
Date:5/15/2009

ORLANDO (May 15, 2009)Fox Chase Cancer Center researchers have discovered that low-oxygen regions in prostate tumors can be used to predict a rise in prostate-specific antigen (PSA) levels, a marker of tumor recurrence in prostate cancer. The long-term study results will be presented at the 2009 American Society of Clinical Oncology annual meeting in Orlando, FL.

Aruna Turaka, M.D., radiation oncology fellow at Fox Chase and lead author on the study, explained that low oxygen, or hypoxia, in tumors is a well-known risk factor for radiation resistance in solid tumors. Between 2000 and 2002, Fox Chase research colleagues published six research papers detailing the link between tumor hypoxia, radioresistance, and the risk of increased PSA levels. But mean follow-up at the time of those studies was 19 months, she said. The current study reinforces those preliminary findings with more "mature" data and a median follow-up of 8 years.

In the current study, Turaka and her colleagues used a custom-built probe to monitor the amount of oxygen that prostate tumors and non-cancerous muscle tissue were receiving. They used this probe on 57 patients with low or intermediate risk of cancer just before the patients received a form of localized radiation therapy. The researchers then tracked the patients over time, looking for a correlation between the amount of oxygen levels in the prostate tumor relative to the muscle tissue at the time of therapy and later looked at the increase in PSA levels.

Eight of the 57 patients experienced an increase in PSA levels following prostate cancer treatment, defined as an increase of 2 ng/mL above the lowest PSA reading following brachytherapy. Overall, average muscle oxygenation was 12.5-times higher than that of the tumor (30 mm Hg vs 2.4 mm Hg). Using a statistical model that accounted for such risk factors as tumor grade, PSA level, and tumor size, the team determined that hypoxia was a significant independent
'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Cocaine Spurs Long-Term Change in Brain Chemistry
2. Implanted Defibrillators Boost Long-Term Survival
3. John Hancock Selects CHCS Services to Manage Long-Term Care Insurance Provider Discount and Caregiver Programs
4. AAHSA Joins Sixty Aging and Disability Groups to Fight for Long-Term Services and Supports in Health Care Reform
5. Heinz Family Philanthropies (www.heinzfamily.org) Release New Facts About Cards, Highlighting Questions Families Should Ask About Long-Term Care -- 10 Questions to Answer... (www.tenquestionstoanswer.org)
6. AAHSA President Discusses Long-Term Care Solution at SCAN Foundation/Health Affairs Conference
7. Aging Advocate Named President of Marylands Leading Long-Term Care Association
8. Despite the Economic Downturn, Long-Term Growth Potential in the US Dental Biomaterial Market Remains Robust
9. Community Approach Necessary For Affordable Long-Term Care, Says NCB Capital Impact
10. Ochsner and Australia Partner for Long-Term Solution to Physician Shortages
11. First 10-year follow-up shows that treatment with AVONEX leads to long-term benefits in early multiple sclerosis patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... (PRWEB) September 20, 2014 MarijuanaDoctors.com ... successful showing at the PAIN Week conference that ... Hotel and Casino in Las Vegas from September ... primarily attended PAIN Week in the hopes of ... a viable and legitimate tool to treat chronic ...
(Date:9/19/2014)... Nearly 780 Risperdal lawsuits are moving forward ... meeting took place to discuss the next steps in ... court’s mass tort program. Attorneys for the plaintiffs and ... the Complex Litigation Center in Philadelphia’s City Hall where ... Risperdal lawsuits filed against Johnson & Johnson and its ...
(Date:9/19/2014)... 19, 2014 “Copay coupons,” a drug ... brand drugs among patients with prescription drug coverage, may ... a new report from the Department of Health ... Federal anti-kickback laws prohibit suppliers from offering side-payments to ... federal government. , The report highlights that two recent ...
(Date:9/19/2014)... KS (PRWEB) September 19, 2014 Unbound ... responding to families in regions of the Philippines being affected ... , More than 1,060 families evacuated to the nearest public ... Fung-Wong brought heavy rain and gusty winds to portions of ... causing heavy flooding. Some homes filled with more than 10 ...
(Date:9/19/2014)... -- As kids transition from elementary to middle school, ... a recent study. But the researchers studying ... verbal and physical bullying declines as students get older. ... strategies must address all types of bullying as well ... researchers said. The study was published recently in ...
Breaking Medicine News(10 mins):Health News:MarijuanaDoctors.com Experiences Unprecedented Support and Growth at Pain Week 2014 2Health News:Risperdal Lawsuits Move Forward As Attorneys Meet To Discuss Litigation, Reports Wright & Schulte LLC 2Health News:Risperdal Lawsuits Move Forward As Attorneys Meet To Discuss Litigation, Reports Wright & Schulte LLC 3Health News:Risperdal Lawsuits Move Forward As Attorneys Meet To Discuss Litigation, Reports Wright & Schulte LLC 4Health News:PCMA: New OIG Report Cites Drug Manufacturer“Copay Coupon” Use in Medicare Part D 2Health News:Double Threat in Philippines Displaces Thousands of Unbound Families 2Health News: Cyberbullying Seems to Ramp Up in Middle School 2
... ... Point Solutions has been awarded the prestigious Gold certification from Cisco ... specialization. The Certification recognizes High Point,s expert level of achievement ... Communication, and Data Center. Gold Certified Partners are considered extensions of ...
... Biotherapeutics Inc. ("GENova") clarified today information disseminated in previous ... portfolio. , GENova owns the rights to a range ... all of them. The patents have not yet been ... been brought to GENova,s attention that previous releases were ...
... ... chiropractor, has taken over Optimal Body Chiropractic within Tuscan Sun Massage & Wellness in ... all ages by enhancing the relationship between the spine, nervous system, and the rest ... ...
... Public Health has been awarded $18.4 million by the ... Department of Defense to establish an Extremity Trauma Clinical ... coordinating center for the Consortium that includes a network ... several major military treatment centers and the U.S. Army ...
... young adults with acoustic neuromas , FRIDAY, Sept. 11 (HealthDay ... her mother,s voice or the sound of a dog barking. ... she had neurofibromatosis type 2 (NF2), a condition characterized by ... damaged the eighth cranial nerve in one ear. , The ...
... Sept. 11 United American Healthcare Corporation (Nasdaq: UAHC ... fourth fiscal quarter and full year ended June 30, 2009 on ... to file its Form 10-K for the period ended June 30, ... in compliance with applicable regulations. In addition, the Company announced ...
Cached Medicine News:Health News:High Point Solutions has Been Awarded the Prestigious Gold Certification from Cisco Systems 2Health News:GENova issues clarifying press release 2Health News:Chiropractic Helps Strengthen Immune System and Prevent Sickness 2Health News:JHSPH to lead extremity trauma clinical research consortium 2Health News:JHSPH to lead extremity trauma clinical research consortium 3Health News:Cancer Drug Shrinks Benign Tumors That Steal Hearing 2Health News:Cancer Drug Shrinks Benign Tumors That Steal Hearing 3Health News:United American Healthcare Corporation Announces Release Date for Fiscal 2009 Fourth Quarter and Full Year Results 2
(Date:9/19/2014)... 19, 2014 Larry J. Merlo , President ... will speak before the National Press Club in ... recent move to stop selling tobacco products and its leadership ... health. "Dramatic changes in our health care system ... government," Merlo has said. "CVS Health has a truly unique ...
(Date:9/19/2014)... SOUTH EASTON, Mass. , Sept. 19, 2014 ... the "Company") today announced it has received and ... throughput Barozyme HT48 instruments and has begun to ... believes the first instrument will be ready for ... will be built and released at a rate ...
(Date:9/19/2014)... and ORLANDO, Fla. , Sept. ... Inspire therapy continues to grow, with the publication of ... on-line in Otolaryngology – Head and Neck ... a worsening of both objective and subjective measures of ... attribute Inspire therapy for the reduction in obstructive sleep ...
Breaking Medicine Technology:CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 2CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 3Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 2New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 4
... InspireMD, Inc. (OTC BB: NSPR) ("Inspire" or the ... commercialization of its proprietary stent platform technology, today announced that ... ended September 30, 2011 with the U.S. Securities and Exchange ... Year-to-Date Highlights Year-to-date shipment ...
... The new harder to crush version of OxyContin® has ... research revealed at a conference of law enforcement officers ... Prevention (CDC) announced that every day 100 people die ... prescription opioid pain relievers. A new formulation of the ...
Cached Medicine Technology:InspireMD Reports Record Third Quarter 2011 Operating and Financial Results and Strategic Update 2InspireMD Reports Record Third Quarter 2011 Operating and Financial Results and Strategic Update 3InspireMD Reports Record Third Quarter 2011 Operating and Financial Results and Strategic Update 4InspireMD Reports Record Third Quarter 2011 Operating and Financial Results and Strategic Update 5InspireMD Reports Record Third Quarter 2011 Operating and Financial Results and Strategic Update 6InspireMD Reports Record Third Quarter 2011 Operating and Financial Results and Strategic Update 7InspireMD Reports Record Third Quarter 2011 Operating and Financial Results and Strategic Update 8InspireMD Reports Record Third Quarter 2011 Operating and Financial Results and Strategic Update 9New OxyContin® Has Lower Street Price Than Old Crushable Formulation 2