Navigation Links
Long-term pharmacotherapy for obesity and overweight: updated meta-analysis
Date:11/16/2007

Patients taking anti-obesity drugs will only see modest weight loss and many will remain significantly obese or overweight, according to a study published on bmj.com today.

The study, which looked at the long-term effectiveness of anti-obesity medications, found that three drugs recommended for long-term use - orlistat, sibutramine and rimonabant, reduced weight by less than 5kg (11 pounds). This equated to a loss of less than 5% of total body weight. Guidelines from the National Institute for Clinical Excellence recommend stopping the use of anti-obesity drugs if 5% of total body weight is not lost after three months.

While making changes to lifestyle and diet are recommended as the initial treatment for obesity, the use of anti-obesity drugs is common. Its estimated that in 2005 global sales of anti-obesity drugs reached $1.2billion. Current UK guidelines recommend using drug therapy in addition to making lifestyle changes if a patient has a body mass index of greater than 30.

The Canadian researchers reviewed the evidence from thirty placebo-controlled trials where adults took anti-obesity drugs for a year or longer. The mean weight of the volunteers in all of the trials was 100kg (15.7 stone). The mean body mass index levels were 35 36.

Professor Raj Padwal and colleagues found orlistat reduced weight by 2.9kg, sibutramine by 4.2kg and rimonabant by 4.7kg. They also found that patients taking the weight loss pills were significantly more likely to achieve 5 10% weight loss, compared to those who took the placebo.

The health benefits associated with taking the drugs varied. For example, orlistat reduced the incidence of diabetes in one trial and all three drugs lowered patients levels of certain types of cholesterol. Adverse effects were recorded with all three drugs, in particular, rimonabant increased the risk of mood disorders such as depression or anxiety. The authors no
'/>"/>

Contact: Emma Dickinson
edickinson@bmj.com
44-020-738-36529
BMJ-British Medical Journal
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Smoking may strongly increase long-term risk of eye disease
2. Long-Term Fatigue Plagues Cancer Survivors
3. Dont Ignore Tough or Long-Term Stomach Pain
4. Shaking may cause brain damage and serious long-term effects to infants
5. Sexual function affected by stem cell transplant according to long-term study
6. Smoking can harm the long-term effects of some oral surgery procedures
7. Childhood Obesity Epidemic a Long-Term Challenge
8. Conseco to Host Follow-Up Long-Term Care Conference Call
9. New Report Finds Information Technology Essential But Not Sufficient in Long-Term Care
10. No Link Between Amateur Boxing, Long-Term Brain Damage
11. No strong evidence linking amateur boxing with long-term brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... , ... August 03, 2015 , ... Sutter Health’s California ... operating officer (COO) at CPMC. Hamila will start in her role effective immediately and ... , Kownacki has worked at CPMC and Sutter Health for about 15 years, including ...
(Date:8/3/2015)... ... August 03, 2015 , ... The Workgroup for Electronic ... health IT to create efficiencies in healthcare information exchange, announced the release of its ... Health and Human Services (HHS) Secretary, WEDI shared survey results and ...
(Date:8/3/2015)... ... 03, 2015 , ... Kantor & Kantor, LLP announced today ... client Rebecca Hamsher, deciding that in accordance with ERISA ( Employee Retirement Income ... treatment for bulimia, depression and other mental health problems. , According to the ...
(Date:8/3/2015)... (PRWEB) , ... August 03, 2015 , ... ... Health notes that while an overwhelming number of Hispanics believe people can ... The overwhelming 70 percent of participants queried said making diet changes was important. ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... its industry-defining contract lifecycle management solution, as well as announced the date of ... the speed and ease of contract management tasks as well as enhancements to ...
Breaking Medicine News(10 mins):Health News:Hamila Kownacki, RN Appointed as New Chief Operating Officer at CPMC 2Health News:WEDI ICD-10 Survey Results: Industry Nearing Readiness but Physician Practices Lagging Behind 2Health News:WEDI ICD-10 Survey Results: Industry Nearing Readiness but Physician Practices Lagging Behind 3Health News:WEDI ICD-10 Survey Results: Industry Nearing Readiness but Physician Practices Lagging Behind 4Health News:Kantor & Kantor Announces North Cypress Medical Center Must Reimburse Benefits for Mental Health Treatment 2Health News:Kantor & Kantor Announces North Cypress Medical Center Must Reimburse Benefits for Mental Health Treatment 3Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 2Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 3Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 4Health News:Novatus Unveils Milestone Software Release 2
... Feb. 6 MaxCyte, Inc., a,clinical-stage therapeutics company ... Douglas Doerfler, President & CEO, will be,presenting at ... York,Waldorf=Astoria, on Monday, February 11, 2008 at 11:45AM., ... overview and discuss the,company,s preclinical and clinical product ...
... of nevirapine greatly reduced infant infections in Africa, ... News) -- The antiretroviral drug nevirapine greatly reduces ... virus to their babies during breast-feeding, according to ... Nevirapine is already in widespread use in developing ...
... Introduces World,s First Collaborative Platform to Integrate, ... WAYLAND, Mass., Feb. 6 Tourtellotte ... for the bio-pharmaceutical industry, is,pleased to announce ... document,management and collaboration platform for complex document ...
... Inc. (Amex:,UPI), a medical device company that develops, ... of voiding dysfunction,announced today that it will be ... on Wednesday, February 20, 2008 at the Ritz ... and Medi Jiwani,Uroplasty,s Vice President and CFO, will ...
... PHILADELPHIA, Feb. 6 The much,anticipated launch ... eToims(R),Soft Tissue Comfort Center, LLC, a University ... Intramuscular,Stimulation (eToims(R) Twitch Relief Method). The site ... including back pain (the second most,common neurological ...
... well as standard, invasive method , , TUESDAY, Feb. 5 (HealthDay ... cancer has spread may be better than traditional, invasive procedures. ... of the Journal of the American Medical Association , ... era for people with lung cancer or suspected lung cancer. ...
Cached Medicine News:Health News:Drug Helps Prevent Breast-Feeding Moms From Passing on HIV 2Health News:Tourtellotte Solutions' Fusion DMC(TM) Unifies the World of Bio-Pharma Documents 2Health News:StopMusclePain.com Launched as Only Website Dedicated to Reversing Back Pain 2Health News:Less Invasive Way to Stage Lung Cancer Shows Promise 2Health News:Less Invasive Way to Stage Lung Cancer Shows Promise 3
(Date:8/3/2015)... , Aug. 3, 2015  Depomed, Inc. (NASDAQ: ... Horizon Pharma plc,s (NASDAQ: HZNP ) ("Horizon") announcement ... Directors ("Depomed Board") set a record date to determine ... The Depomed Board will review the request ... received today and contains the information required under Depomed,s ...
(Date:8/3/2015)... According to a new ... Market Study on Physiotherapy Equipment - ... 2022", the global physiotherapy equipment market is estimated to be ... and is expected to grow at a CAGR ... for US$23.7 Bn by 2022. View Full ...
(Date:8/3/2015)... , August 3, 2015 ... biotech companies, military surgical research and top-tier ... with regards to severe wound treatments for ... for regenerative medicine and tissue-engineered skin substitute ... and advancements in focus are Amarantus Bioscience ...
Breaking Medicine Technology:Depomed Comments on Horizon Pharma Announcement 2Depomed Comments on Horizon Pharma Announcement 3Depomed Comments on Horizon Pharma Announcement 4Depomed Comments on Horizon Pharma Announcement 5Depomed Comments on Horizon Pharma Announcement 6Global Physiotherapy Equipment Market Will Reach US$ 23.7 Billion by 2022: Persistence Market Research 2Global Physiotherapy Equipment Market Will Reach US$ 23.7 Billion by 2022: Persistence Market Research 3Global Physiotherapy Equipment Market Will Reach US$ 23.7 Billion by 2022: Persistence Market Research 4Biotech Advancements Coupled with Collaborative Partnerships Focus on Developing Orphan Drug Products & Treatments for Critical-Care Patients With Severe Wound Conditions 2Biotech Advancements Coupled with Collaborative Partnerships Focus on Developing Orphan Drug Products & Treatments for Critical-Care Patients With Severe Wound Conditions 3Biotech Advancements Coupled with Collaborative Partnerships Focus on Developing Orphan Drug Products & Treatments for Critical-Care Patients With Severe Wound Conditions 4Biotech Advancements Coupled with Collaborative Partnerships Focus on Developing Orphan Drug Products & Treatments for Critical-Care Patients With Severe Wound Conditions 5Biotech Advancements Coupled with Collaborative Partnerships Focus on Developing Orphan Drug Products & Treatments for Critical-Care Patients With Severe Wound Conditions 6
... is a lateral-flow immuno-chromatographic assay intended for ... specific to Helicobacter pylori in human serum, ... convenient, non-invasive, and easy to perform test ... of H.pylori infection in patients with clinical ...
... HP is a visually read, qualitative immunochromatographic ... H. pylori, a bacterium that grows in ... ulcer disease and some gastric cancers. FlexSure ... blood or serum samples, provides the physician ...
... Infectious Mononucleosis test is designed to ... serum, plasma or whole blood. The ... extract of bovine erythrocytes which give ... similar extracts prepared from sheep and ...
... The QuickVue Influenza A+B test ... of influenza type A and type ... nasal wash and/or nasal aspirate specimens. ... aid in the rapid differential diagnosis ...
Medicine Products: