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Long-term neuropsychological impairment is common in acute lung injury survivors
Date:4/5/2012

ety were found in 36, 39, and 62 percent of long-term survivors.

Enrollment in a conservative fluid-management strategy was significantly associated with the development of cognitive impairment, and lower partial pressure of arterial oxygen during the trial was associated with a significantly increased risk of both cognitive and psychiatric impairment. "Although it is plausible that use of a conservative fluid-management strategy was associated with an increased risk for long-term cognitive impairment," Dr. Mikkelsen said, "based on the small sample size and an unclear mechanism, this finding warrants confirmation."

The study had a few limitations, including its small sample size and the use of self-report for several measures.

"Our study confirms earlier research showing that cognitive and psychiatric morbidity are common among long-term survivors of ALI," concluded Dr. Mikkelsen. "We are indebted to the NIH for supporting EA-PAC, the parent study of the present study, and for recognizing the importance of assessing a multitude of long-term outcomes to properly understand survivorship and ultimately to improve the lives of critically ill survivors."


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Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

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