Navigation Links
Long-term methadone treatment can affect nerve cells in brain
Date:8/15/2012

Long-term methadone treatment can cause changes in the brain, according to recent studies from the Norwegian Institute of Public Health. The results show that treatment may affect the nerve cells in the brain. The studies follow on from previous studies where methadone was seen to affect cognitive functioning, such as learning and memory.

Since it is difficult to perform controlled studies of methadone patients and unethical to attempt in healthy volunteers, rats were used in the studies. Previous research has shown that methadone can affect cognitive functioning in both humans and experimental animals.

Sharp decrease in key signaling molecule

Rats were given a daily dose of methadone for three weeks. Once treatment was completed, brain areas which are central for learning and memory were removed and examined for possible neurobiological changes or damage.

In one study, on the day after the last exposure to methadone, there was a significant reduction (around 70 per cent) in the level of a signal molecule which is important in learning and memory, in both the hippocampus and in the frontal area of the brain. This reduction supports findings from a previous study (Andersen et al., 2011) where impaired attention in rats was found at the same time. At this time, methadone is no longer present in the brain. This indicates that methadone can lead to cellular changes that affect cognitive functioning after the drug has left the body, which may be cause for concern.

No effect on cell generation

The second study, a joint project with Southwestern University in Texas, investigated whether methadone affects the formation of nerve cells in the hippocampus. Previous research has shown that new nerve cells are generated in the hippocampus in both adult humans and rats, and that this formation is probably important for learning and memory. Furthermore, it has been shown that other opiates such as morphine and heroin can inhibit this formation. It was therefore reasonable to assume that methadone, which is also an opiate, would have the same effect.

However, the researchers did not find any change in the generation of new nerve cells after long-term methadone treatment. If the same is true in humans, this is probably more positive for methadone patients than continuing with heroin. However, the researchers do not know what effect methadone has on nerve cells that have previously been exposed to heroin.

Large gaps in knowledge

Since the mid-1960s, methadone has been used to treat heroin addiction. This is considered to be a successful treatment but, despite extensive and prolonged use, little is known about possible side effects. There are large knowledge gaps in this field.

Our studies show that prolonged methadone treatment can affect the nerve cells, and thus behaviour, but the results are not always as expected. Many more pre-clinical and clinical studies are needed to understand methadone's effect on the brain, how this can result in altered cognitive function, and, if so, how long these changes last. Knowledge of this is important - both for the individual methadone patient and the outcome of treatment.


'/>"/>

Contact: Julie Johansen
julie.johansen@fhi.no
Norwegian Institute of Public Health
Source:Eurekalert

Related medicine news :

1. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
2. Long-term neuropsychological impairment is common in acute lung injury survivors
3. Supporting LGB children may influence their long-term health, BU study finds
4. Optimal care of bariatric surgery patients vital for long-term health and well-being
5. Many Primary Care Docs Dont Know Long-Term Effects of Chemo: Survey
6. Study says children exposed to tobacco smoke face long-term respiratory problems
7. More Research Points to Long-Term Ills With Bone Drugs
8. Long-term ICS use reduces pleural effusion in patients with CAP
9. Group B streptococcal meningitis has long-term effects on childrens developmental outcomes
10. Long-Term Salty Diets Tied Again to High Blood Pressure
11. Long-term cancer survivors struggle to keep regular work hours
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... May 27, 2016 , ... With ... pharmaceutical, medical and food industries. Aside from its GMP accreditation, Validation Center is ... of successfully certified products, services and staff. , Validation Center is ISO17025 accredited ...
(Date:5/26/2016)... Louis, Missouri (PRWEB) , ... May 26, 2016 ... ... cost, quality and clinical outcomes, hosted members and suppliers for its inaugural Member ... a focus on their mission of elevating the operational health of America’s healthcare ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... that has a significant negative impact on long-term patient survival, reports a team ... results, published online this week in the Journal of Thoracic and Cardiovascular Surgery, ...
(Date:5/26/2016)... ... , ... An April Gallup survey found rising health care costs to be ... Health Senior Living (SHSL) may not share those same worries thanks to a ... the year, while holding the line on increasing their contributions, including premiums, deductibles and ...
(Date:5/26/2016)... , ... May 26, 2016 , ... The Lung ... host a six-week smoking cessation class starting June 6 at their clinic in downtown ... http://www.gnahec.org . , Additionally, the Lung Institute has created a free downloadable 4 Week ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016 ... 2016"market research report that provides an overview on ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ... reviews key players involved in the therapeutic development ...
(Date:5/24/2016)...   , Study met both ... superiority in , Excellent plus Good ... of the ascending colon   , ... today announced new positive data from the phase III MORA study ... 2 litre PEG with ascorbate. The study met both primary endpoints ...
(Date:5/24/2016)... , May 24, 2016 Celsion Corporation ... development company, today provided an update on its ... clinical trial combining GEN-1, the Company,s DNA-based immunotherapy, ... of newly-diagnosed patients with advanced ovarian cancer who ... surgery.  GEN-1 is an IL-12 DNA plasmid vector ...
Breaking Medicine Technology: