Long-term inhaled dry powder mannitol improves lung func... ( Adding inhaled dry powder mannitol t...)

Long-term inhaled dry powder mannitol improves lung function in CF

Date:12/15/2011

Adding inhaled dry powder mannitol to standard therapy for cystic fibrosis produced sustained improvement in lung function for up to 52 weeks, according to a new study. Along with the treatment's efficacy and good safety profile, the convenience and ease of administration of mannitol treatment may improve adherence with therapy in these patients.

In the double-blind study, which was supported by Pharmaxis Limited, 318 patients were randomized to treatment with 400 mg bid inhaled mannitol or 50 mg bid inhaled mannitol (control group) for 26 weeks, followed by an additional 26 weeks of open-label active treatment. A 50 mg dose was chosen as the control because it was felt it would not be clinically effective, based on an earlier dose escalation study. Mannitol was given on top of a background of typical concomitant therapy such as recombinant human deoxyribonuclease and inhaled antibiotics.

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

"Patients in the treatment group showed a 106.5 mL mean improvement in forced expiratory volume in one second (FEV1), an 8.22 percent improvement from baseline, compared with a 52.4 mL improvement (4.47 percent) in the control group," said lead author Moira L. Aitken, MD, professor of pulmonary and critical care medicine at the University of Washington Medical Center. "Forced vital capacity increased 136.3 mL in the treatment group, compared with 65.0 mL in the control group. Treated patients also experienced fewer pulmonary exacerbations than controls."

The difference in absolute FEV1 between the study and control groups approached statistical significance (p=0.059), while the difference in relative change from baseline FEV1 between groups reached significance (p=0.029). Improvements in FEV1 were maintained in the treatment group during the 26-week open-label extension phase of
'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

0

GOOD

Page: 1 2
Related medicine news :

1. Ecstasy May Cause Long-Term Changes in Brain Chemistry
2. Zoledronic acid shows long-term benefit in survivorship for premenopausal ER-positive breast cancer
3. Cholesterol-Lowering Drugs Safe for Long-Term Use, Study Finds
4. Vascular risk linked to long-term antiepileptic drug therapy
5. Early, intensive therapy for type 1 diabetes prevented kidney disease in long-term study
6. Sleeping sickness drug may provide long-term protection against skin cancer
7. Elderly long-term care residents suffer cognitively during disasters
8. African-American women with gestational diabetes face high long-term diabetes risk
9. Long-Term Unemployment Can Tax Mental Health
10. For Many, Epilepsy Surgery Effective Long-Term
11. Medicare patients at risk of long-term institutionalization after hospital stay

Post Your Comments:

(Date:5/18/2013)... California (PRWEB) May 18, 2013 Online watch ... be Rolex watch owners at a fraction of ... of luxury timepieces in the world, buyers are urged to ... compared to buying a Rolex watch from a brick-and-mortar store, ... owned Rolex watches priced at unbelievable rates. Although some ...

(Date:5/18/2013)... Thompson HealthDay Reporter , , FRIDAY, May 17 ... the latest edition of what is considered the "bible" ... many changes continues. "This is unprecedented, the amount ... Lieberman, president-elect of the American Psychiatric Association (APA). "It,s ... it is. You have to evaluate it and then ...

(Date:5/18/2013)... (HealthDay News) -- Just a few extra cups of ... an autoimmune liver disease known as primary sclerosing cholangitis ... Mayo Clinic in Rochester, Minn., found that drinking coffee ... disease, which can lead to cirrhosis of the liver, ... not prove a cause-and-effect relationship. "While rare, ...

(Date:5/18/2013)... The use of a smartphone application significantly ... new research presented today at Digestive Disease Week ... advance of the procedure, includes dietary restrictions and ... at strict intervals. The better the preparation, the ... and precancerous polyps in the colon. The study, ...

(Date:5/18/2013)... ROCHESTER, Minn. -- Regular consumption of coffee is ... cholangitis (PSC), an autoimmune liver disease, Mayo Clinic ... the Digestive Disease Week 2013 conference in Orlando, ... of the bile ducts that results in inflammation ... of the liver, liver failure and biliary cancer. ...

Breaking Medicine News(10 mins):Health News:Time and Gems Offers Buyers the Largest Collection of Rolex Watches Yet 2 Health News:Time and Gems Offers Buyers the Largest Collection of Rolex Watches Yet 3 Health News:Latest Edition of Psychiatry's 'Bible' Launched Amid Controversy 2 Health News:Latest Edition of Psychiatry's 'Bible' Launched Amid Controversy 3 Health News:Latest Edition of Psychiatry's 'Bible' Launched Amid Controversy 4 Health News:Study Links Coffee to Lower Risk for Rare Liver Disease 2 Health News:New smartphone application improves colonoscopy preparation 2

[0] Time and Gems Offers Buyers the Largest Collection of Rolex Watches Yet [0] Latest Edition of Psychiatry's 'Bible' Launched Amid Controversy [0] Study Links Coffee to Lower Risk for Rare Liver Disease [0] New smartphone application improves colonoscopy preparation [0] Consuming coffee linked to lower risk of detrimental liver disease, Mayo Clinic finds

... - Exclusive, multi-year contract executed by Intercell and ... First sales of IXIARO under this military contract ... ICLL; OTC Bulletin Board: INRLY) announced today that ... contract with the Defense Logistics Agency (DLA), Defense ...

... Sunday, individuals all over the nation will be celebrating a ... life: their mothers. While people in the United States turn ... (IBMP) hopes to inspire some to also think of mothers ... the United States send their breast milk to infants in ...

... may be used someday against Parkinson,s, too, expert suggests, , , ... to lend a hand in the death of brain cells ... according to a newly published study. , ... normally guides molecules in and out of cells, but it ...

... and recovery fairly quick , , FRIDAY, May 8 (HealthDay News) ... from over, with hundreds of new cases being reported each day, ... issue that,s been concerning me, that has to do with a ... over," Dr. Richard Besser, acting director of the U.S. Centers for ...

... Almost Family, Inc. (Nasdaq: AFAM ), a ... that William Yarmuth, President and Chief Executive Officer, and Steve ... to present at two upcoming investor conferences. The first ... 2009 Growth Stock Conference at the Four Seasons Hotel in ...

... ANN ARBOR, Mich., May 8 Thomson Reuters on ... hospital system for significantly improving the quality and managing ... plans and Tallahassee Memorial HealthCare are overall winners of ... hospitals and healthcare payers that use data analytics to ...

Intercell Executes Multi-Year Contract for Supply of IXIARO(R) to the United States Military International Breast Milk Project Helps Mothers Worldwide Protein Might Mute Effects of Methamphetamine As Swine Flu Cases Mount, CDC Says U.S. Hasn't 'Dodged a Bullet'Almost Family to Present at Two Upcoming Conferences Thomson Reuters Honors Keystone Mercy and AmeriHealth Mercy Health Plans and Tallahassee Memorial HealthCare

(Date:5/18/2013)... , May 18, 2013 Faruqi ... firm, is investigating potential securities fraud at AVEO ... (Logo: http://photos.prnewswire.com/prnh/20120119/MM38856LOGO ) ... and its executives violated federal securities laws by ... Company,s Phase III drug trials for Tivopath (tivozanib) ...

(Date:5/17/2013)... , May 17, 2013 Orexigen® Therapeutics, Inc. (Nasdaq: ... company overview at the UBS Global Healthcare Conference in ... Wednesday, May 22 nd at 11 a.m. Eastern Time. ... the presentation, please visit the Investor Relations section of the ... be available for 14 days after the event. ...

(Date:5/17/2013)... YORK , May 17, 2013 /PRNewswire-iReach/ -- United ... Advanced Cardiac Life Support (ACLS), Pediatric Advanced Life Support ... free PALS, BLS and ACLS online course ... manuals, people simply need to build an account with ... materials for these programs, United Medical Education is setting ...

Breaking Medicine Technology:Faruqi & Faruqi, LLP Encourages Investors Who Suffered Losses In Excess Of $100,000 Investing In AVEO Pharmaceuticals, Inc. To Contact The Firm 2 ACLS Online Course Manuals are Now Available at No Cost through United Medical Education 2

[0] Faruqi & Faruqi, LLP Encourages Investors Who Suffered Losses In Excess Of $100,000 Investing In AVEO Pharmaceuticals, Inc. To Contact The Firm [0] Orexigen Therapeutics to Present at the UBS Global Healthcare Conference [0] ACLS Online Course Manuals are Now Available at No Cost through United Medical Education

... BETHESDA, Md., April 14 Micromet, Inc.,(Nasdaq: ... novel, proprietary,antibodies for the treatment of cancer, ... meeting of the American Association for,Cancer Research ... that commercial,anti-cancer antibodies trastuzumab (Herceptin(R); Genentech, Roche),cetuximab ...

... the, Tumor Suppressor P53 Inhibited Tumor Growth Synergistically in Preclinical ... ... 14 ,Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM ) announced today that ... 2008 Annual Meeting of the American Association for Cancer Research,(AACR) further ...

Cached Medicine Technology:Micromet Demonstrates That the Antibodies in Commercial Products Herceptin, Erbitux, Vectibix and Xolair Can Be Converted Into Highly Potent, T Cell- Engaging BiTE Antibodies 2 Micromet Demonstrates That the Antibodies in Commercial Products Herceptin, Erbitux, Vectibix and Xolair Can Be Converted Into Highly Potent, T Cell- Engaging BiTE Antibodies 3 Micromet Demonstrates That the Antibodies in Commercial Products Herceptin, Erbitux, Vectibix and Xolair Can Be Converted Into Highly Potent, T Cell- Engaging BiTE Antibodies 4 Micromet Demonstrates That the Antibodies in Commercial Products Herceptin, Erbitux, Vectibix and Xolair Can Be Converted Into Highly Potent, T Cell- Engaging BiTE Antibodies 5 Preclinical Study Presented at AACR Annual Meeting Shows Broad Anti-Cancer Potential of Peregrine's anti-PS Vascular Targeting Antibodies 2 Preclinical Study Presented at AACR Annual Meeting Shows Broad Anti-Cancer Potential of Peregrine's anti-PS Vascular Targeting Antibodies 3 Preclinical Study Presented at AACR Annual Meeting Shows Broad Anti-Cancer Potential of Peregrine's anti-PS Vascular Targeting Antibodies 4

Micromet Demonstrates That the Antibodies in Commercial Products Herceptin, Erbitux, Vectibix and Xolair Can Be Converted Into Highly Potent, T Cell- Engaging BiTE Antibodies Preclinical Study Presented at AACR Annual Meeting Shows Broad Anti-Cancer Potential of Peregrine's anti-PS Vascular Targeting Antibodies

Touch-Trol Pediatric Suction Catheter Mini-Tray...

SAFE-T-VAC Suction Catheter Kits with Protective Sleeve...

Our suction kits include a Tri-Flo® suction catheter, a pop-up solution basin and two sturdy, precuffed latex exam gloves in an inner wallet. Infant and pediatric kits (5/6, 8 and 10 Fr) feature ...

... kit includes a Tri-Flo® suction ... for flushing and lubrication, two ... inner wallet and a rigid ... (5/6, 8 and 10 Fr) ...

Medicine Products:

Touch-Trol Suction Pediatric Catheter Mini-Tray SAFE-T-VAC Suction Catheter Kits with Protective Sleeve AirLife™ Brand Cath-N-Glove® Suction Kits In Peel Pouch Rigid Suction Tray Kits With Saline