Navigation Links
Long-term hormone replacement therapy increases breast cancer risk
Date:5/28/2008

Are you taking or did you take hormones? If yes, which hormone medication and for how long? When did you stop taking hormone replacement medication? 3,464 breast cancer patients and 6,657 healthy women between the ages of 50 and 74 years participated in a large survey and elicited detailed information about hormone replacement medications they are taking or used to take for relief of menopausal symptoms. The survey was prompted by the MARIE case-control study carried out by the German Cancer Research Center (DKFZ) and the University Hospitals in Hamburg-Eppendorf, Germany. The goal of this 6-year study, which was financed by the German Cancer Aid (Deutsche Krebshilfe), was to determine the effect of hormones both on their own and in association with other factors on breast cancer risk.

Women who have taken menopausal hormone therapy before have a 37 percent higher risk of breast cancer than women who have never taken hormone replacement therapy (HRT). During the actual time of HRT use the risk is even elevated by 73 percent. Within five years after cessation of therapy the risk of breast cancer in former HRT users falls back to the level of women who never used HRT. These results of the MARIE study confirm findings of two U.S. and U.K. studies (Womens Health Initiative Study and Million Women Study) that caused a stir in 2002 and 2003, says Professor Dr. Wilhelm Braendle of Hamburg-Eppendorf University Hospitals, who headed the study.

It has often been argued that the results of the U.S. study could not be applied to Germany where prescription practices are completely different. Therefore, we captured the various hormone preparations, especially the various progestins, very precisely. We have obtained similar results as the U.S. researchers, Professor Dr. Jenny Chang-Claude of DKFZ summarizes. With our new data, we provide physicians in Germany with solid information that will help them to advise their patients about the benefits and risks of hormone replacement therapy.

The MARIE study also confirms that different hormone preparations have different effects: Compared to the risk of women who have never used HRT, a combined therapy of estrogen and progestin doubles the risk of breast cancer, while use of estrogen alone (estrogen replacement therapy) raises the risk by only 15 percent. However, in both cases the risk increases only if hormones are taken for more than five years.

Hormone replacement therapy also appears to have a different influence on different types of breast cancer, Braendle explains. The risk of developing one of the less common lobular or tubular breast cancers increases twice as much under HRT as the risk of the common type of ductal carcinoma, which constitutes 40 to 75 percent of all malignant tumors of the breast.


'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Related medicine news :

1. Study concludes no racial disparities in long-term outcomes in recipients of liver transplants
2. Long-term cognitive decline in bypass patients not due to surgery
3. Dont Wait for the Election to Plan Your Long-Term Healthcare, Insurance Leader Advises
4. New Data Shows Continued Growth of Long-Term Disability Claims and Decline in Social Security Disability Insurance Applications Approval Rate
5. APIC Recommendations on Infection Prevention in Long-Term Care Facilities
6. Ohio Health Care Association Elects North Canton Long-Term Care Provider as President
7. After divorce, stable families help minimize long-term harm to children
8. Ohio Health Care Association Hosts Midwests Largest Long-Term Care Convention in Columbus
9. SAPPHIRE trial shows long-term benefit of carotid stenting as alternative to surgery
10. 2004 long-term care act raised costs and worsened care, study shows
11. Childhood Leukemia Survivors Struggle With Long-Term Comorbidities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... According to a new study by ... it does not obey the rules Congress has directed the CBO to follow. The ... GOP reform would restore. Yet, it estimates a reduction in employer-based coverage due to ...
(Date:3/24/2017)... Orion, MI (PRWEB) , ... March 24, 2017 ... ... insurance assistance, financial planning, and related services to families and business owners across ... initiative aimed at feeding regional families struggling with financial difficulties. , The Oxford/Orion ...
(Date:3/24/2017)... Pittsburgh, PA (PRWEB) , ... March 24, 2017 ... ... the Oncology Nursing Society (ONS) wanted to create a communications platform that positions ... realize this goal, Elliance and ONS reinvented their online publication as an always-on, ...
(Date:3/24/2017)... ... March 24, 2017 , ... The law firm of Enea, ... pleased to announce Westchester resident Lauren C. Enea has joined the firm as an ... will concentrate her practice in elder law, Medicaid planning and applications, and Wills, Trusts ...
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... the year of enhancements, upgrading their training and leads programs. , In February, ... Reserved for elite sales agents, Performance Partners is designed to teach how to ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)...  The U.S. Food and Drug Administration today granted ... adults and pediatric patients 12 years and older with ... not received prior chemotherapy. This is the first FDA-approved ... skin cancer. "While skin cancer is one ... form called Merkel cell cancer have not had an ...
(Date:3/23/2017)...   BioSpace , the leading biotechnology and pharmaceutical ... Indiana Biosciences Research Institute and over 20 dynamic ... to bring the state,s life sciences industry to the ... artistic representation of the region,s booming biotechnology and pharmaceutical ... Mike Pence , a long-time advocate of the ...
(Date:3/23/2017)... March 23, 2017  Digital Pharmacist Inc. ( ... a rapidly growing digital health company, announced today ... that allows patients to manage their prescriptions. Over ... as Denver Health Pharmacy, USave Pharmacy and Owen,s ... Digital Pharmacist accelerate its product development schedule, the ...
Breaking Medicine Technology: