Navigation Links
Long-term daily multivitamin supplement use decreases cataract risk in men
Date:2/20/2014

SAN FRANCISCO Feb. 20, 2014 Long-term daily multivitamin supplement use may lower cataract risk in men, according to a study of nearly 15,000 male physicians published this month in Ophthalmology, the journal of the American Academy of Ophthalmology.

Past observational studies have indicated a relationship between nutritional supplement use and eye health. However, randomized trial data on the effects of long-term multivitamin supplement use and risk of eye diseases are limited and, in some cases, non-existent. To address this, researchers based at Brigham and Women's Hospital and Harvard Medical School as part of the Physicians' Health Study II (PHS II) conducted a randomized, double-blind study from 1997 to 2011 of 14,641 U.S. male doctors age 50 and older. Half took a common daily multivitamin, as well as vitamin C, vitamin E and beta carotene supplements. The other half took a placebo. The researchers followed the participants to identify how many participants in each group developed new cases of two common eye diseases: cataract, which is a clouding of the eye's lens, and age-related macular degeneration (AMD), the deterioration of the eye's macula that is responsible for the ability to see fine details clearly.

The researchers found that in the placebo group 945 cases of cataract developed, which were self-reported and confirmed by medical records, while only 872 cases of cataract developed in the multivitamin group, representing a 9 percent decrease in risk. This risk was even lower, at 13 percent, for nuclear cataract, which occurs at the center of the lens and is the most common variety of cataract associated with the aging process. Given that an estimated 10 million adults in the United States have impaired vision due to cataract, even a modest reduction in risk of cataract has potential to improve public health outcomes.

"If multivitamins really do reduce the risk of cataract, even by a modest 10 percent, this rather small reduction would nonetheless have a large public health impact," said William Christen, ScD, the study's lead author and researcher from Harvard Medical School.

In terms of AMD risk, the researchers found there were 152 new cases of visually significant (best corrected visual acuity of 20/30 or worse) AMD in the multivitamin group compared to 129 in the placebo group, but the difference was not statistically significant. While this finding may seem to contradict results of other studies, such as Age-Related Eye Disease Study (AREDS), the researchers note that the studies had different nutrient supplements, dosing and objectives. AREDS included daily zinc and a high-dose antioxidant combination of vitamin E, vitamin C and beta carotene, whereas the multivitamin in PHS II included these nutrients and many others. All the nutrients were provided to the PHSII participants at the U.S. Recommended Dietary Allowance dose levels, which are much lower than the AREDS supplements. Furthermore, the objective in AREDS was to prevent AMD progression among persons who already had the disease, whereas the objective of PHS II was to prevent new cases of AMD, and thus persons with a diagnosis of AMD at baseline were not included.

"This finding of more cases of AMD in the multivitamin group than in the placebo group, although not statistically significant, does raise some concerns," added Dr. Christen. "Clearly, this finding needs to be examined further in other trials of multivitamin supplements in both men and women."

The American Academy of Ophthalmology recommends the use of antioxidant vitamin and mineral supplements as recommended in the AREDS reports, including high daily doses of vitamin C, vitamin E, beta-carotene, zinc and copper only for patients who have intermediate or advanced AMD. Patients are advised to contact their ophthalmologist to learn if these supplements are appropriate for them. Some people should not take large doses of antioxidants or zinc for medical reasons. Current smokers and patients with a smoking history should be advised to avoid taking beta-carotene because of the increased risk of lung cancer and consider taking the other components of the AREDS formulation. The recent AREDS2 results would suggest other nutrients such as lutein and zeaxanthin may be an appropriate substitution for beta-carotene in the formulation.

The Academy does not at this time have a recommendation for the use of nutritional supplements to prevent cataracts or delay their progression.


'/>"/>

Contact: Media Relations
media@aao.org
415-561-8534
American Academy of Ophthalmology
Source:Eurekalert

Related medicine news :

1. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
2. Long-term neuropsychological impairment is common in acute lung injury survivors
3. Supporting LGB children may influence their long-term health, BU study finds
4. Optimal care of bariatric surgery patients vital for long-term health and well-being
5. Many Primary Care Docs Dont Know Long-Term Effects of Chemo: Survey
6. Study says children exposed to tobacco smoke face long-term respiratory problems
7. More Research Points to Long-Term Ills With Bone Drugs
8. Long-term ICS use reduces pleural effusion in patients with CAP
9. Group B streptococcal meningitis has long-term effects on childrens developmental outcomes
10. Long-Term Salty Diets Tied Again to High Blood Pressure
11. Long-term cancer survivors struggle to keep regular work hours
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... ... May 28, 2016 , ... "Color Grading media can be time ... preset onto their media," said Christina Austin - CEO of Pixel Film Studios. ... and easily add stylish color grades to their footage. A LUT is a Lookup ...
(Date:5/28/2016)... ... ... of the city where’s it’s easy to spot the neon lights of chains serving fast ... diners with a taste for real food. , On May 13, the Best ... urban casual restaurant focusing on dishes made by hand with wholesome, organic ingredients that are ...
(Date:5/27/2016)... ... May 27, 2016 , ... Two director-level employees of Horizon ... to Women and Industry (TWIN) 2016 honorees. The award recognizes businesswomen who excel ... year, Geri Boone, Director of the MLTSS (Managed Long-Term Services and Supports) Program at ...
(Date:5/27/2016)... ... May 27, 2016 , ... With over 60 percent of acute stroke ... a sustainable product to aid in the rehabilitation process has steadily increased. Ekso Bionics ... individuals with hemiplegia due to stroke. , Ekso Bionics has now received clearance from ...
(Date:5/27/2016)... ... May 27, 2016 , ... ... educate the many who are unaware of the plight of aphasia. In collaboration ... within the “Stroke Awareness” campaign. , The link between stroke and aphasia is ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... 27, 2016 Hutchison China ... focused on the highly lucrative global oncology and ... of potential first-in-class or best-in-class tyrosine kinase inhibitor ... with strategic partners. HCM,s profitable Chinese healthcare business ... We expect progress of the mid-to-late-stage pipeline during ...
(Date:5/26/2016)... , May 26, 2016 A ... growth is the emergence of new treatments. Cardax, a ... for osteoarthritis treatment. The therapy is expected to fulfil ... Research UK is conducting studies to develop new treatments ... where the genes involved in osteoarthritis are being investigated, ...
(Date:5/25/2016)... 25, 2016 According to a ... (3D, 2D, 4D), by Therapeutic Area (Oncology, Cosmeceutical/Plastic Surgery), ... (Medical Device Manufacturers, Hospitals/ Clinics) - Forecast to 2021", ... Animation Market for the forecast period of 2016 to ... Million by 2021 from USD 117.3 Million in 2016, ...
Breaking Medicine Technology: