Navigation Links
Long-term cognitive decline in bypass patients not due to surgery
Date:5/19/2008

Among the many factors involved in deciding how to treat coronary artery disease, physicians must evaluate overall outcomes and the potential for complications. Some studies have found that cognitive decline and neurologic complications, such as stroke, have been associated with coronary artery bypass surgery. A new study finds no evidence that bypass patients have a greater risk of long-term cognitive decline than patients not undergoing surgery. The study is published in the May 2008 issue of Annals of Neurology (http://www.interscience.wiley.com/), the official journal of the American Neurological Association.

Led by Ola A. Selnes and Guy M. McKhann of the Johns Hopkins University School of Medicine, the study involved 152 patients who had bypass surgery and 92 patients with coronary artery disease who did not have surgical intervention. Patients underwent a series of memory and other cognitive tests at the beginning of the study period, and after 3, 12, 36 and 72 months. Of these, 96 bypass patients and 61 control patients completed cognitive testing after six years.

The results showed that there were no significant differences in cognitive scores between the two groups at the beginning of the study. Both groups showed modest decline in cognitive performance during the study period, but there were no significant differences in the degree of decline between the groups after six years.

The authors point out that the bypass patients had conditions that might be associated with worse cognitive performance, including higher incidence of cardiovascular risk factors, more severe coronary artery disease and more surgery requiring general anesthesia during the follow-up period. Despite these factors, no differences between the two groups were found. While other studies have looked at the long-term effects of bypass surgery on cognitive function, this is the first prospective long-term study comparing cognitive outcomes of bypass patients to cardiac patients who did not have surgery.

The lack of any difference in the long-term cognitive trajectories between the surgery patients and our study controls suggests that late cognitive decline 5 or more years after CABG is not specific to the use of cardiopulmonary bypass, the authors state.

As to why cognitive changes occurred in both groups, there is evidence that patients with risk factors for vascular disease (such as high blood pressure) and markers of atherosclerosis (hardening of the arteries) have higher rates of cognitive decline over time than patients without these risk factors. The authors note that since both groups in the study had such risk factors, it is likely that the cognitive decline is related either to normal aging in the context of cardiovascular disease or to progression of the underlying vascular disease over time. More studies are needed, however, to determine if better control of these risk factors would lessen the degree of cognitive decline in patients with coronary artery disease.

The authors note that the study emphasizes the importance of including control subjects when studying long-term cognitive outcomes after surgical procedures. They conclude that the risk of late cognitive decline should not be a consideration when choosing between types of intervention for coronary artery disease.


'/>"/>

Contact: Sean Wagner
swagner@wiley.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Dont Wait for the Election to Plan Your Long-Term Healthcare, Insurance Leader Advises
2. New Data Shows Continued Growth of Long-Term Disability Claims and Decline in Social Security Disability Insurance Applications Approval Rate
3. APIC Recommendations on Infection Prevention in Long-Term Care Facilities
4. Ohio Health Care Association Elects North Canton Long-Term Care Provider as President
5. After divorce, stable families help minimize long-term harm to children
6. Ohio Health Care Association Hosts Midwests Largest Long-Term Care Convention in Columbus
7. SAPPHIRE trial shows long-term benefit of carotid stenting as alternative to surgery
8. 2004 long-term care act raised costs and worsened care, study shows
9. Childhood Leukemia Survivors Struggle With Long-Term Comorbidities
10. Spirit II explores long-term performance of XIENCE V stent
11. Governor Rendell Announces Own Your Future Campaign; Urges Consumers to Better Plan Their Long-Term Care Needs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... , ... Only two months after the official release of The Private Collection ... XO Private has initiated a second print-run of its lavish luxury travel coffee table ... when open, weighs in at more than six kilos, retails at EUR 1,000 per ...
(Date:2/24/2017)... ... 2017 , ... The Smart Machine Age is here, and it’s disrupting everything. ... of all jobs in the United States may be taken over by technology in ... aggressive know-it-all who steamrolls over colleagues is drawing to a close. Success will belong ...
(Date:2/24/2017)... ... February 24, 2017 , ... The narrative in “ Signal 8: ... ’s true account of his paramedic experiences. Schanssema describes the tragedies he saw, as ... attempts to overcome them. , Schanssema, initially unsure of the career path he wanted ...
(Date:2/24/2017)... ... ... The International Association of Eating Disorders Professionals (iaedp) announces the 2017 top five ... art competition. Selected from 15 submissions from around the nation, the top five finalists ... iaedp Symposium, March 22 – 26 in Las Vegas. , This year, the competition ...
(Date:2/24/2017)... , ... February 24, 2017 , ... ... into the Senior International Elite division on February 12th. Ms. Esparza qualified ... at the elite qualifier competition held in Las Vegas, Nevada. Frida is one ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... Research and Markets has announced the addition of the "Urinary ... their offering. ... The latest research Urinary Incontinence Drugs Price Analysis and Strategies - ... Incontinence market. The research answers the following questions: ... Incontinence and their clinical attributes? How are they positioned in the ...
(Date:2/23/2017)... , Südkorea, 23. Februar 2017 LG ... für Sterilisationsaufgaben vorgestellt. Die Sterilisationsleistung beträgt das 1,5-fache des ... ultraviolette Strahlung im Bereich zwischen 200 und 280 nm und ... von Bakterien, indem es ihre DNA zerstört. Das Produkt ... ...
(Date:2/23/2017)... -- Research and Markets has announced the addition of the ... their offering. ... research Menopause Drugs Price Analysis and Strategies - 2016, provides drug pricing ... the following questions: What are the key ... in the Global Menopause market? What are the unit ...
Breaking Medicine Technology: