Navigation Links
Long-term cognitive decline in bypass patients not due to surgery
Date:5/19/2008

Among the many factors involved in deciding how to treat coronary artery disease, physicians must evaluate overall outcomes and the potential for complications. Some studies have found that cognitive decline and neurologic complications, such as stroke, have been associated with coronary artery bypass surgery. A new study finds no evidence that bypass patients have a greater risk of long-term cognitive decline than patients not undergoing surgery. The study is published in the May 2008 issue of Annals of Neurology (http://www.interscience.wiley.com/), the official journal of the American Neurological Association.

Led by Ola A. Selnes and Guy M. McKhann of the Johns Hopkins University School of Medicine, the study involved 152 patients who had bypass surgery and 92 patients with coronary artery disease who did not have surgical intervention. Patients underwent a series of memory and other cognitive tests at the beginning of the study period, and after 3, 12, 36 and 72 months. Of these, 96 bypass patients and 61 control patients completed cognitive testing after six years.

The results showed that there were no significant differences in cognitive scores between the two groups at the beginning of the study. Both groups showed modest decline in cognitive performance during the study period, but there were no significant differences in the degree of decline between the groups after six years.

The authors point out that the bypass patients had conditions that might be associated with worse cognitive performance, including higher incidence of cardiovascular risk factors, more severe coronary artery disease and more surgery requiring general anesthesia during the follow-up period. Despite these factors, no differences between the two groups were found. While other studies have looked at the long-term effects of bypass surgery on cognitive function, this is the first prospective long-term study comparing cognitive outcomes of bypass patients to cardiac patients who did not have surgery.

The lack of any difference in the long-term cognitive trajectories between the surgery patients and our study controls suggests that late cognitive decline 5 or more years after CABG is not specific to the use of cardiopulmonary bypass, the authors state.

As to why cognitive changes occurred in both groups, there is evidence that patients with risk factors for vascular disease (such as high blood pressure) and markers of atherosclerosis (hardening of the arteries) have higher rates of cognitive decline over time than patients without these risk factors. The authors note that since both groups in the study had such risk factors, it is likely that the cognitive decline is related either to normal aging in the context of cardiovascular disease or to progression of the underlying vascular disease over time. More studies are needed, however, to determine if better control of these risk factors would lessen the degree of cognitive decline in patients with coronary artery disease.

The authors note that the study emphasizes the importance of including control subjects when studying long-term cognitive outcomes after surgical procedures. They conclude that the risk of late cognitive decline should not be a consideration when choosing between types of intervention for coronary artery disease.


'/>"/>

Contact: Sean Wagner
swagner@wiley.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Dont Wait for the Election to Plan Your Long-Term Healthcare, Insurance Leader Advises
2. New Data Shows Continued Growth of Long-Term Disability Claims and Decline in Social Security Disability Insurance Applications Approval Rate
3. APIC Recommendations on Infection Prevention in Long-Term Care Facilities
4. Ohio Health Care Association Elects North Canton Long-Term Care Provider as President
5. After divorce, stable families help minimize long-term harm to children
6. Ohio Health Care Association Hosts Midwests Largest Long-Term Care Convention in Columbus
7. SAPPHIRE trial shows long-term benefit of carotid stenting as alternative to surgery
8. 2004 long-term care act raised costs and worsened care, study shows
9. Childhood Leukemia Survivors Struggle With Long-Term Comorbidities
10. Spirit II explores long-term performance of XIENCE V stent
11. Governor Rendell Announces Own Your Future Campaign; Urges Consumers to Better Plan Their Long-Term Care Needs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the loss ... author, William Nowers. Captain Nowers and his wife, Millie, have six children, ten ... the Navy. Following his career as a naval aviator and carrier pilot, he ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 ... characterized by frequent cessation in breathing. Oral appliances can offer significant relief to ...
(Date:10/12/2017)... Wis. (PRWEB) , ... October 12, 2017 , ... ... standard products to meet the demand of today’s consumer and regulatory authorities worldwide. ... of probiotic experts and tested to meet the highest standard. , These ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of ... Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, ... In honor of Morris F. Collen, a pioneer in the field of medical informatics, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the ... to develop to enable prevention of a major side effect of chemotherapy in ... in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... 25, 2017   Montrium , an industry ... today—from the IQPC Trial Master Files & Inspection ... that EastHORN Clinical Services has selected eTMF ... TMF management. EastHORN, a leading European contract research ... increase transparency to enable greater collaboration with sponsors, ...
(Date:9/23/2017)... Pa. , Sept. 22, 2017 Janssen ... a complete response letter from the U.S. Food and ... seeking approval of sirukumab for the treatment of moderately ... letter indicates additional clinical data are needed to further ... moderately to severely active RA. ...
(Date:9/22/2017)... -- AVACEN Medical (AVACEN) announced that its CE-Marked AVACEN ... with the widespread pain associated with fibromyalgia in the ... Essex, England commented, "I had difficulty ... sleep at all, tremendous pain, with every movement sending ... AVACEN 100] enough, how this has and is helping ...
Breaking Medicine Technology: