Navigation Links
Long-term cognitive decline in bypass patients not due to surgery
Date:5/19/2008

Among the many factors involved in deciding how to treat coronary artery disease, physicians must evaluate overall outcomes and the potential for complications. Some studies have found that cognitive decline and neurologic complications, such as stroke, have been associated with coronary artery bypass surgery. A new study finds no evidence that bypass patients have a greater risk of long-term cognitive decline than patients not undergoing surgery. The study is published in the May 2008 issue of Annals of Neurology (http://www.interscience.wiley.com/), the official journal of the American Neurological Association.

Led by Ola A. Selnes and Guy M. McKhann of the Johns Hopkins University School of Medicine, the study involved 152 patients who had bypass surgery and 92 patients with coronary artery disease who did not have surgical intervention. Patients underwent a series of memory and other cognitive tests at the beginning of the study period, and after 3, 12, 36 and 72 months. Of these, 96 bypass patients and 61 control patients completed cognitive testing after six years.

The results showed that there were no significant differences in cognitive scores between the two groups at the beginning of the study. Both groups showed modest decline in cognitive performance during the study period, but there were no significant differences in the degree of decline between the groups after six years.

The authors point out that the bypass patients had conditions that might be associated with worse cognitive performance, including higher incidence of cardiovascular risk factors, more severe coronary artery disease and more surgery requiring general anesthesia during the follow-up period. Despite these factors, no differences between the two groups were found. While other studies have looked at the long-term effects of bypass surgery on cognitive function, this is the first prospective long-term study comparing cognitive outcomes of bypass patients to cardiac patients who did not have surgery.

The lack of any difference in the long-term cognitive trajectories between the surgery patients and our study controls suggests that late cognitive decline 5 or more years after CABG is not specific to the use of cardiopulmonary bypass, the authors state.

As to why cognitive changes occurred in both groups, there is evidence that patients with risk factors for vascular disease (such as high blood pressure) and markers of atherosclerosis (hardening of the arteries) have higher rates of cognitive decline over time than patients without these risk factors. The authors note that since both groups in the study had such risk factors, it is likely that the cognitive decline is related either to normal aging in the context of cardiovascular disease or to progression of the underlying vascular disease over time. More studies are needed, however, to determine if better control of these risk factors would lessen the degree of cognitive decline in patients with coronary artery disease.

The authors note that the study emphasizes the importance of including control subjects when studying long-term cognitive outcomes after surgical procedures. They conclude that the risk of late cognitive decline should not be a consideration when choosing between types of intervention for coronary artery disease.


'/>"/>

Contact: Sean Wagner
swagner@wiley.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Dont Wait for the Election to Plan Your Long-Term Healthcare, Insurance Leader Advises
2. New Data Shows Continued Growth of Long-Term Disability Claims and Decline in Social Security Disability Insurance Applications Approval Rate
3. APIC Recommendations on Infection Prevention in Long-Term Care Facilities
4. Ohio Health Care Association Elects North Canton Long-Term Care Provider as President
5. After divorce, stable families help minimize long-term harm to children
6. Ohio Health Care Association Hosts Midwests Largest Long-Term Care Convention in Columbus
7. SAPPHIRE trial shows long-term benefit of carotid stenting as alternative to surgery
8. 2004 long-term care act raised costs and worsened care, study shows
9. Childhood Leukemia Survivors Struggle With Long-Term Comorbidities
10. Spirit II explores long-term performance of XIENCE V stent
11. Governor Rendell Announces Own Your Future Campaign; Urges Consumers to Better Plan Their Long-Term Care Needs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica Scruggs ... for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs surgery, ... Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, MD, ...
(Date:6/25/2016)... ... 25, 2016 , ... Dr. Calvin Johnson has dedicated his ... implemented orthobiologic procedures as a method for treating his patients. The procedure is ... to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to help ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- The vast majority of dialysis patients currently receive ... usually 3 times a week, with treatment times averaging ... equipment preparation and wait time.  This regimen can be ... who are elderly and frail.  Many elderly dialysis patients ... for some duration of time. Residents in ...
(Date:6/23/2016)... 23, 2016  Experian Health, the healthcare ... the patient payment and care experience, today ... products and services that will enhance the ... offerings. These award-winning solutions will enable healthcare ... compliant in an ever-changing environment and redefine ...
(Date:6/23/2016)...  The National Pharmaceutical Council (NPC) today announced ... research organization as its newest member.  ... president and chief scientific officer, Mallinckrodt Pharmaceuticals, will ... Board of Directors. ... us in support of our efforts to conduct ...
Breaking Medicine Technology: