Navigation Links
Long struggle for appropriately processed manufacturer data leads to a new assessment of memantine
Date:4/27/2011

After the manufacturer of the Alzheimer's drug memantine submitted a supplementary analysis of study data, the German Institute for Quality and Efficiency in Health Care (IQWiG) sees proof of a benefit of the drug for cognitive function, as well as indications of a benefit for activities of daily living, at least for a treatment period of 6 months. This changes the conclusions of the first IQWiG benefit assessment of 2009. IQWiG had repeatedly called upon the manufacturer Merz to provide a renewed analysis of study data appropriate to the research question.

Additional effort may also be worthwhile for manufacturers

IQWiG's Director Jrgen Windeler comments on the new assessment result: "As in many other projects, in the assessment of memantine the Institute was also confronted with gaps in the evidence. If this is the case, then we make suggestions as to how these gaps can be closed. Sometimes additional new studies are required; sometimes it suffices if the manufacturer provides or supplements data already available, as was the case for memantine. In the end, the additional effort paid off."

In the first IQWiG assessment, data from two studies were missing

In Germany the drug memantine is marketed under the tradenames "Axura" and "Ebixa", and is approved for the treatment of moderate to severe Alzheimer's disease. In a first benefit assessment , prepared after commissioning by the Federal Joint Committee (G-BA) and published in September 2009, IQWiG found no proof that patients with Alzheimer's disease could benefit from memantine. However, among other things, relevant information on two studies was missing, which the manufacturer had not provided to IQWiG.

Additional analysis did not consider all of the relevant studies

At the beginning of 2010, Merz submitted the results of these two studies, as well as additional analyses of a larger number of studies, to the G-BA. IQWiG subsequently published a second assessment in the form of a working paper in August 2010. However, this did not change the conclusions of the first report. This was also due to the fact that IQWiG could not utilize the additional analyses as presented by Merz. For example, among other things, Merz had again failed to include all of the relevant studies. However, in its working paper IQWiG described how an appropriate analysis of the data could be performed.

Absence of deterioration may also mean an improvement

These additional analyses, in which the data were processed appropriately, were finally submitted by Merz to the G-BA in October 2010. These were "responder analyses". In this type of analysis, a count is made of how many patients experience a notable improvement in their health status after treatment, i.e. are "responders".

For this purpose it is specified how big this difference has to be in a patient in order to be classified as an improvement. Then, both in the placebo and in the memantine groups, all patients are counted who at least achieved this improvement. In the case of a progressive disease such as Alzheimer's, the absence of deterioration may also be regarded as an improvement.

Indications of a benefit for activities of daily living

As the analysis now submitted shows, the number of patients whose short- and long-term memory (cognitive function) notably deteriorated over a period of at most 6 months was lower in the memantine group. IQWiG classifies this result as proof of a benefit.

Such a difference in favour of memantine was also shown for activities of daily living (e.g. concerning personal hygiene); however, this was considerably smaller. In addition, in contrast to the outcome "cognitive function", the criteria according to which patients were classified as treatment responders have not proved themselves through year-long testing in studies. This leads to greater uncertainty in the interpretation of results. Consequently, overall IQWiG assumes an indication - not proof - of a benefit of treatment with memantine for this outcome.

Long-term studies are lacking

It remains unclear whether memantine improves quality of life, as for this outcome the studies available still allow no conclusions to be drawn. The results for cognitive function and activities of daily living now submitted only apply with time restrictions, as none of the studies lasted longer than 6 months. "We still have no long-term studies. However, particularly for Alzheimer's drugs this type of study is urgently required, as they are usually taken for several years," says Jrgen Windeler.


'/>"/>

Contact: IQWiG
info@iqwig.de
49-022-135-6850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Related medicine news :

1. 3.1 Million Hispanic Americans Struggle With Arthritis
2. Woman Struggles to Control Cholesterol
3. Children living with relatives struggle with physical, mental health issues
4. Processed, Fatty Foods May Dumb Down Your Kids: Study
5. Safe & Secure Online Pharmacy Viamedic.com; Reaches Milestone of 1.5 Million Orders Processed
6. Processed Meat May Harm the Heart
7. Salmonella Tennessee Identified in a Processed Food Ingredient
8. Bling My Sling LL Announces Website Launch - A fashionable arm sling manufacturer, announce the opening of their new website bling-my-sling.com
9. Linguistics professor examines manufacturers prescription drug websites
10. Leading Electronic Cigarette Manufacturer Vapure Announces U.S. Made E-Liquid
11. Small Supplement And Vitamin Manufacturers Must Meet FDA cGMP Requirements By The End Of The Month
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... While it’s often important to take certain medications during the ... Texas, has identified a solution. , She developed a prototype for MOTION LIGHT-UP PILL ... it eliminates the need to turn on a light when taking medication during the ...
(Date:10/13/2017)... ... 13, 2017 , ... Lori R. Somekh, founder of the Law Office ... of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our office ... forum to network with elder law attorneys nationwide,” said Somekh. , ElderCounsel ...
(Date:10/13/2017)... NJ (PRWEB) , ... October 13, 2017 , ... Global ... at scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global ... physical activity. The fun run is geared towards children of all ages; it ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “America On The ... identity. “America On The Brink” is the creation of published author, William Nowers. ... great-grandchildren. As a WWII veteran, he spent thirty years in the Navy. ...
(Date:10/12/2017)... CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... cold therapy products, announced today the introduction of an innovative new design of the ... multipurpose pad so you get maximum comfort while controlling your pain while using cold ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... , Oct. 4, 2017  According to the Centers for Disease ... end of October . PhysicianOne Urgent Care is helping communities across ... Westchester, NY , by offering no-cost* flu shots through the end ... mandated by certain health insurance regulations. ... The best time to get a flu shot is by the end ...
(Date:10/2/2017)... 2, 2017  Eli Lilly and Company (NYSE: ... the third quarter of 2017 on Tuesday, October 24, ... that day with the investment community and media to ... conference call will begin at 9 a.m. Eastern time. ... live webcast of the conference call through a link ...
(Date:10/2/2017)... 2, 2017 The Rebound mobile app is poised ... reverse the tide of prescription drug addiction. The app empowers ... intake and stepping down their dosage in a safe, controlled ... December 2017; the first 100,000 people to sign up will ... http://www.rebound-solution.com/ ...
Breaking Medicine Technology: