Navigation Links
Long distance signals protect brain from viral infections
Date:2/10/2014

The brain contains a defense system that prevents at least two unrelated virusesand possibly many morefrom invading the brain at large. The research is published online ahead of print in the Journal of Virology.

"Our work points to the remarkable ability of the immune system, even within the brain, to protect us against opportunistic viruses," says Anthony van den Pol of Yale University, an author on the study.

The research explains a long-standing mystery. The olfactory mucosa in the nose can serve as a conduit for a number of viruses to enter the brain including rabies, polio and influenza viruses. Yet infections in the central nervous system rarely occur. The mechanism responsible for protecting the brain from viruses that successfully invade the olfactory bulb (OB), the first site of infection in nasal mucosa, remains elusive.

Van den Pol and his colleagues have discovered that, in response to viral infection, cells in the olfactory bulb release long-distance signaling molecules that tell cells in uninfected parts of the brain to produce anti-viral interferon, a first line of defense against invading viruses.

In the study, normal mice expunged the infection, while mice lacking receptors for the initial signaling molecules succumbed as the viruses spread throughout the brain, proving the critical role of these molecules.

These signaling molecules are different than regular neurotransmitters. Van den Pol notes that during neuronal signaling, neurotransmitters released by one cell travel across a mere 20 nanometers of synapse to the next nerve cell. Yet, the long-distance signaling molecules diffuse up to 15 millimeters.

"That distance is almost a million times greater than the distance across a synapse," he says.

"The success of the immune system in blocking two unrelated viruses, vesicular stomatitis virus and cytomegalovirus, suggests that our results may generalize to many other viruses that can enter the brain through the olfactory nerve," says van den Pol.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related medicine news :

1. Blade Runner Golf Announces a Tour Model Chipper That Is Versatile from 7 Iron Distances and Provides Success for Any Players Skill Level
2. MedMar Healing Center Co-founder Rafael Hernandez Goes the Distance for Leukemia and Lymphoma Society, Running Three Marathons for Nonprofit Health Organization
3. Med Transport Center Introduces a $500 Holiday Gift Certificate on 4 Long Distance Medical Transportation Services
4. Green Swan, Inc. Introduces The Cell Spacer™, a Device That Puts Distance Between a Mobile Phone User’s Head and Headset
5. Broad-Connect Telecom Introduces Essential Voice SIP, Long Distance SIP and Toll-Free SIP
6. More Than 55 Percent of STD Positives Not Worried About Distance for Match
7. Elite Long Distance Runner Amy Hastings Signs With ZAMST
8. How Does Psychological Distance Work Between Non-millionaires and Millionaires in Dating?
9. Machine-Like Performance in Skateboarding Receives Guinness World Record™ Status for Performance at The International Distance Skateboard Association Ultraskate
10. Global Autism Project Announces Distance Supervision for Autism Professionals
11. Urology-owned radiation oncology self-referral can increase patients travel distance for treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... ... 25, 2017 , ... Splashtop Inc. , the worldwide ... new addition to the Mirroring360 product family combines device screen mirroring with screen ... enables educators, business professionals and individuals to stream or mirror app screens, music, ...
(Date:4/25/2017)... , ... April 25, 2017 , ... ... attempts to compare student test score performance for the 2015-16 school year across ... state’s voucher programs. Though it highlights important patterns in student test score performance, ...
(Date:4/25/2017)... (PRWEB) , ... April 25, 2017 , ... ... the way in unveiling cutting-edge birth defects research related to Zika virus during ... the world’s premier society for this important science. , The Teratology ...
(Date:4/25/2017)... ... ... Emergency Physician and Distinguished Professor of Emergency Medicine Bentley Bobrow will be featured ... publish in summer 2017. , Dr. Bobrow, MD, FACEP, FAHA, is an Emergency ... He also serves as Medical Director for the Bureau of Emergency Medical Services and ...
(Date:4/24/2017)... ... 2017 , ... LG CNS Healthcare Solutions debuted the next ... Telehealth 2.0, the American Telemedicine Association’s national conference. , BYOD has been added ... pre-programmed tablet in a remarkably easy-to-use kit for patients. “BYOD is the next ...
Breaking Medicine News(10 mins):
(Date:4/24/2017)... , April 24, 2017 SW Safety ... protection, and comfort, announces the release of the latest ... This most recent example of leading edge nitrile glove ... pattern for 200% more tactile grip on wet and ... and durability. With TracTek and a suite of other ...
(Date:4/20/2017)... 2017  Vivify Health, the pioneer and market leader ... a very significant patent for the advancement of healthcare ... via digital health.  This landmark patent provides the company ... secures Vivify,s position as the leader in remote care.  ... first company to apply consumer mobile devices, wireless biometrics, ...
(Date:4/20/2017)... 20, 2017 Research and Markets has announced ... Driven by Rapidly Expanding Injectables Market and Increasing Usage of Complex ... ... technologies will rise from USD 20 Billion in 2015 to around ... Delivery Technologies - Innovation Driven by Rapidly Expanding Injectables Market and ...
Breaking Medicine Technology: