Navigation Links
Long-acting beta-agonists most effective step-up therapy for children with poorly controlled asthma
Date:3/2/2010

For children whose asthma is not well controlled and on low doses of inhaled corticosteroids, a long-acting beta-agonist (LABA) may be the most effective of three possible step-up treatments. National Jewish clinician-scientists Stanley Szefler, Joseph Spahn, Ronina Covar Gary Larsen and Lynn Taussig, and colleagues in the NIH-funded Childhood Asthma Research and Education Network published their findings March 2, 2010, online in the New England Journal of Medicine.

"This study gives physicians confidence in using long-acting beta-agonists if a patient is not responding to steroid treatment alone," said said Dr. Szefler, Professor of Pediatrics and Pharmacology at National Jewish Health. "It also shows that children respond quite differently to different step-up therapies. Doctors need to monitor their patients closely and consider switching to a higher dose of inhaled corticosteroids or a leukotriene receptor antagonist if the long-acting beta agonist does not improve asthma control."

Approximately 7 million children in the United States have asthma. The prevalence has more than doubled in the past several decades. Asthma in the United States accounts for 500,000 hospitalizations, 10.5 million physician-office visits, and 3,500 deaths as well as millions of missed school days.

Almost all the children responded differently to the three step-up therapies. About 45 percent of the children responded best to the long-acting beta agonist salmeterol, 28 percent responded best to the leukotriene receptor antagonist montelukast, and 27 responded best to doubling the dose of the inhaled corticoteroid fluticasone.

The study, called Best Add on Therapy Giving Effective Responses (BADGER), compared the effectiveness of three different step-up treatments in 182 children ages 6 to 18. Participants had mild to moderate persistent asthma that was not controlled on low-dose inhaled corticosteroids.

Researchers also found that certain patient characteristics indentified which step-up treatment would be most effective. African-Americans were equally likely to respond best to LABA step-up or corticosteroid step-up, but not the montelukast. The addition of LABA step-up therapy was most likely to give the best response to white patients, with inhaled corticosteroid step-up the least favorable. The long-acting beta agonist especially likely to help asthma patients who did not have eczema.


'/>"/>

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Medical and Research Center
Source:Eurekalert

Related medicine news :

1. FDA Issues Not-Approvable Letter for Lillys Zyprexa(R) Long-Acting Injection (LAI) for Schizophrenia Treatment
2. Studies Ignite Hope for Long-Acting Allergy Vaccines
3. GlaxoSmithKline Statement on FDA Advisory Committee Vote on Use of Asthma Medicines Containing Long-Acting Beta-Agonists
4. Inspirational Teams of Athletes with Diabetes Build Momentum in 2009 with Sponsorship from Long-Acting Insulin Lantus(R) and Rapid-Acting Insulin Apidra(R)
5. US Back Pain Market Approaches $23 Billion in 2018 - Anticipated Long-Acting, Abuse-Resistant Opioids Drive Value
6. Long-acting insulin analogues in type 2 diabetes: advantage over human insulin not proven
7. Researchers Create Long-Acting Local Anesthetic
8. Olanzapine Long-Acting Injection (LAI) Efficacy and Safety Data Presented at American Psychiatric Association Annual Meeting
9. New Data Demonstrate RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment May Improve Health Outcomes and Reduce Hospitalizations in Patients with Schizophrenia
10. New tool to improve patient understanding of long-acting injectable antipsychotic therapies (LAT) unveiled in April issue of Psychiatry 2009
11. Long-Acting Insulin Works Best for Many Diabetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... , ... LELO has discovered many people are insecure about their ... email, social media and on the Volonté blog seeking advice about how to actually ... or ‘correct’?” , While some methods are more common than others, there is no ...
(Date:5/5/2016)... ... May 05, 2016 , ... Every year 220 ... heartfelt wishes of these children. The wishes provide hope and motivation through ... CEO of Make-A-Wish Mississippi, Brent Wilson said, “In 2016, the organization will grant ...
(Date:5/5/2016)... Portland, Oregon (PRWEB) , ... May 05, 2016 ... ... the Student American Chiropractic Association (SACA) is slated to host the 2016 National ... chance for all current SACA national officers and chapter officers to come together ...
(Date:5/5/2016)... ... May 05, 2016 , ... Tim Dieter ... serving families of greater Dubuque, IA. The current campaign fundraises for Veteran’s Freedom ... veterans. Donations to Veteran’s Freedom Center may now be made here: http://www.veteransfreedomcenter.com/donate/ ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... for veterinary professionals across the United States. The whole food nutrient solutions company ... patients and giving dog, cat and horse owners’ peace of mind. With the ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... ORANGE COUNTY, Calif. , May 5, 2016 ... for nearly a decade due to concerns that ... advances in the approach to imaging, as well ... in a new era of medical peripherals that ... better care.   Ampronix  advanced medical imaging is a ...
(Date:5/5/2016)... 2016 Research ... the  "Europe Thrombocytopenia Market and Competitive ... their offering.       (Logo: ... latest research Europe Thrombocytopenia Market and ... comprehensive insights into Thrombocytopenia pipeline products, ...
(Date:5/4/2016)... , May 4, 2016 ... Market Research entitled "Brain Computer Interface Market - Global Industry ... 2024," the  global brain computer interface (BCI) market  is expected ... The market is estimated to expand at a CAGR ... to 2024. A BCI device provides collaboration ...
Breaking Medicine Technology: