Navigation Links
Long-Term Statin Use Best Way to Cut Cardiovascular Deaths
Date:1/12/2010

Emphasis needed on getting patients to keep taking their meds, researchers say

TUESDAY, Jan. 12 (HealthDay News) -- A 50 percent increase in patients adhering to long-term treatment with cholesterol-lowering statins could prevent twice as many deaths from heart attack and stroke, British researchers say.

It's estimated that only about half of patients prescribed statins to prevent cardiovascular disease are still taking them five years later, according to background information in the analysis.

The researchers reviewed published studies on the sustained use of statins by patients to calculate an assumed average of their capacity to continue treatment over 10 years. The team then used cholesterol and blood pressure data from more than 38,000 patients in Australia to calculate the likelihood of developing cardiovascular disease and the advantages of preventive strategies.

The study authors then calculated patient risk scores according to three scenarios: using the current U.K. National Institute for Health and Clinical Excellence (NICE) guidelines, which recommend that anyone with a 20 percent or greater risk of heart attack or stroke over the next 10 years be prescribed a statin; increased adherence to statin treatment; and lowering the threshold for starting on statins to increase the number of patients taking the drugs.

On the basis of risk factors among the Australian patients, the researchers calculated that 5,390 new cases of cardiovascular disease and 710 related deaths would occur over 10 years. They also determined that 24 percent of patients would be eligible for statin treatment under NICE guidelines. If half (4,563) of those patients fully complied with statin treatment, an estimated 174 cases of cardiovascular disease and 70 deaths would be prevented.

Expanding treatment criteria to allow for 6,991 patients to take statins over the long term would prevent an additional 70 cases of cardiovascular disease and 18 deaths. Improving long-term statin compliance among 6,971 patients would prevent an additional 91 cases of cardiovascular disease and stave off 37 related deaths -- about twice as many as expanding treatment criteria to increase the number of patients eligible to take the drugs.

It's no surprise that focusing on patients most at risk should yield more impressive results, said Dr. Amir Shroufi, who is currently at the Cambridge Institute of Public Health in the United Kingdom, and colleagues.

"However, the magnitude of the difference is notable. And it serves to emphasize the need to find more effective means of increasing adherence -- especially over the long term," the study authors wrote.

The study was released online Jan. 12 in advance of publication in an upcoming print issue of the Journal of Epidemiology and Community Health.

More information

The U.S. Food and Drug Administration has more about statins.



-- Robert Preidt



SOURCE: BMJ Journals, news release, Jan. 11, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Smoking may strongly increase long-term risk of eye disease
2. Long-Term Fatigue Plagues Cancer Survivors
3. Dont Ignore Tough or Long-Term Stomach Pain
4. Shaking may cause brain damage and serious long-term effects to infants
5. Sexual function affected by stem cell transplant according to long-term study
6. Smoking can harm the long-term effects of some oral surgery procedures
7. Childhood Obesity Epidemic a Long-Term Challenge
8. Conseco to Host Follow-Up Long-Term Care Conference Call
9. New Report Finds Information Technology Essential But Not Sufficient in Long-Term Care
10. No Link Between Amateur Boxing, Long-Term Brain Damage
11. No strong evidence linking amateur boxing with long-term brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... ... , ... The producers of Enterprises TV are pleased to present ... world of instantaneous consumption proves very convenient for businesses. With new technologies constantly becoming ... which pollutes our air, water, and soil. It can also threaten the lives of ...
(Date:2/13/2016)... ... 13, 2016 , ... DDi , a Makro company, ... for its expertise in eClinical Solutions. DDi has built its solution competency with ... of global clients. DDi provides smarter technology for Clinical Development, Regulatory and Enterprise ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... to funding innovative lymphoma research and serving the lymphoma community through a comprehensive ... members of South Florida’s philanthropic community at its 10th anniversary Fashion Luncheon on ...
(Date:2/12/2016)... ... February 12, 2016 , ... Coco Libre, the maker ... Red Carpet Events LA GRAMMY’s Style Lounge Event. Coco Libre will offer musicians and ... hydrated before the big event. The invitation-only gifting suite, held this year at the ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Fisher House ... Vegas Mayor John J. Lee, Nevada Military Support Alliance president Scott Bensing, and Peggy ... at the VA Southern Nevada Healthcare System. This will be the first Fisher ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... Feb. 12, 2016   National Community Pharmacists Association ... MBA issued the following statement today in response to ... the Centers for Medicare & Medicaid Services (CMS) ... beneficiary advocates and others: patient advocacy organizations ... still reviewing the full CMS analysis. Our initial reaction ...
(Date:2/12/2016)... , Feb. 12, 2016  Diplomat Pharmacy, Inc. (NYSE: DPLO ) is pleased to ... Account Management and Payor Strategies effective Jan. 23, 2016. ... ... ... Diplomat Specialty Pharmacy ...
(Date:2/12/2016)... MONTREAL , February 12, 2016 ... sofern nicht anders vermerkt)   ... Unternehmens http://www.telestatherapeutics.com abrufbar.    ... Website des Unternehmens http://www.telestatherapeutics.com ... Inc. (TSX:TST; PNK:BNHLF) veröffentlichte heute seinen Konzernabschluss ...
Breaking Medicine Technology: