Navigation Links
Long-Term Erythromycin Cut COPD Complications
Date:11/21/2008

But researchers remain cautious about future antibiotic resistance from widespread use

FRIDAY, Nov. 21 (HealthDay News) -- People with moderate to severe chronic obstructive pulmonary disease (COPD) may be able to reduce the frequency of exacerbations through a regular, low dose of a common antibiotic, a new report says.

The study, published in the first issue for December of the American Journal of Respiratory and Critical Care Medicine, found that twice-daily 250-milligram doses of erythromycin reduced exacerbations by as much as 35 percent.

The double-blind, placebo study found that more than twice as many COPD-related hospitalizations occurred among the placebo group, and that the median duration of the exacerbations was nine days in the erythromycin group, compared with 13 days in the placebo group.

"Our results did not allow us to determine a mechanism for these findings. However, based on in-vitro studies, we suspect that the mechanism is likely to involve the anti-inflammatory properties of erythromycin," study lead author Terence A.R. Seemungal, of the Department of Clinical Medical Sciences at the University of the West Indies, said in an American Thoracic Society news release.

The news is encouraging, following a recent report from the U.S. Centers for Disease Control and Prevention that detailed the rising number of deaths related to COPD.

Seemungal did remain cautious about the findings, noting the threat of future antibiotic resistance resulting from widespread use of erythromycin. Also, not all the study patients received guideline-recommended therapy, such as inhaled corticosteroids or inhaled long-acting bronchodilators, which also have been shown to decrease exacerbation frequency. The degree of added benefit of erythromycin over and above standard therapy will require further study, he said.

"Observations that any intervention might decrease the frequency and severity of acute exacerbations in COPD present considerable public health implications," Dr. John Heffner, past president of the American Thoracic Society, said in the news release. "Exacerbations occur about once a year among patients with moderate to severe COPD and account for more than $30 billion dollars in direct and indirect costs annually in the United States alone."

"Many patients with advanced COPD receive highly potent, extended spectrum antibiotics during acute exacerbations,". "The relative risks of breeding resistance with a long-term preventative use of erythromycin versus more frequent short-term dosing of highly potent antibiotics for acute exacerbations require careful analysis. If future studies demonstrate similar efficacy of prolonged erythromycin therapy, especially if patients are already receiving inhaled steroids and long-acting bronchodilators, the benefits likely will outweigh the risks."

According to the U.S. National Institutes of Health, COPD is a progressive disease that makes it hard to breathe. It can cause coughing that produces large amounts of mucus, wheezing, shortness of breath, chest tightness, and other symptoms. Cigarette smoking is the leading cause of COPD.

More information

The U.S. National Heart, Lung, and Blood Institute has more about chronic obstructive pulmonary disease.



-- Kevin McKeever



SOURCE: American Thoracic Society, news release, Nov. 21, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Smoking may strongly increase long-term risk of eye disease
2. Long-Term Fatigue Plagues Cancer Survivors
3. Dont Ignore Tough or Long-Term Stomach Pain
4. Shaking may cause brain damage and serious long-term effects to infants
5. Sexual function affected by stem cell transplant according to long-term study
6. Smoking can harm the long-term effects of some oral surgery procedures
7. Childhood Obesity Epidemic a Long-Term Challenge
8. Conseco to Host Follow-Up Long-Term Care Conference Call
9. New Report Finds Information Technology Essential But Not Sufficient in Long-Term Care
10. No Link Between Amateur Boxing, Long-Term Brain Damage
11. No strong evidence linking amateur boxing with long-term brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Long-Term  Erythromycin Cut COPD Complications 
(Date:5/26/2017)... ... 2017 , ... “Just What Happened in the Garden of Eden”: retells the stories of three ... the creation of published author, Penelope Colt, mother, trader, horse farmer, artist and a former ... she was three. At six, they moved to Dayton, Ohio, where Penny graduated high ...
(Date:5/24/2017)... ... May 24, 2017 , ... Last month, representatives from Rendina ... and town officials to celebrate the grand opening of the 87,000 square foot ... part of its ongoing relationship with RWJBarnabas Health, New Jersey’s largest health system. ...
(Date:5/24/2017)... ... May 24, 2017 , ... Altec Products, Inc., a leader ... – a one-day technology conference in San Diego, CA. , At nVerge 2017, ... to fully utilize and enhance their Sage ERP solutions by providing improved visibility and ...
(Date:5/24/2017)... ... May 24, 2017 , ... Dr. Manju R. Kejriwal, ... ClearCorrect orthodontics, with or without a referral. Dr. Kejriwal understands the emotional and ... convenient, clear braces in Cincinnati, OH. Patients no longer need to feel the esthetic ...
(Date:5/24/2017)... ... , ... Myers Jackson is well known for auctioning homes that people move ... on the planet. The luxury home market is alive and well and there are ... search of “11 Spyglass Hill Auction will enlighten you on the dynamics of how ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... , May 9, 2017 Zimmer Biomet Holdings, ... musculoskeletal healthcare, today announced it has earned a spot ... 2017" list. The Company was ranked among 500 U.S. ... Employers and Healthcare Equipment and Services. The ... on an anonymous, independent survey of over 30,000 employees ...
(Date:5/8/2017)... 2017 MACRA replaces the outdated sustainable ... service reimbursement. Black Book Research crowdsource-surveyed 8,845 physician practices ... The Market for MIPS Compliance Technology is Booming ... with 3 or more clinicians seek to buy Merit-Based ... the magnitude of the changes, the hunt is on ...
(Date:5/6/2017)... N.Y. , May 5, 2017  Hill-Rom Holdings, ... will add approximately 100,000 square feet to its Welch ... September 2016 its commitment to bring more than 100 ... , where Welch Allyn has maintained a significant presence ... help accommodate these new positions, a large portion of ...
Breaking Medicine Technology: