Navigation Links
Long-Life Gene Might Help Lower Cholesterol
Date:10/11/2007

Drugs boosting SIRT1's activity could be valuable, scientists say

THURSDAY, Oct. 11 (HealthDay News) -- A gene already associated with longer life span may also be linked to a pathway that clears cholesterol from the body, say Massachusetts Institute of Technology (MIT) researchers.

They said their finding could help lead to the creation of drugs that lower the risk of cholesterol-related diseases such as atherosclerosis (clogged arteries) and Alzheimer's disease.

The gene, called SIRT1, prevents cholesterol buildup by activating a cellular pathway that flushes cholesterol from the body using high density lipoprotein (HDL or "good" cholesterol), the team explained.

In their research with mice, the MIT team found that low SIRT1 levels resulted in cholesterol buildup in cells such as macrophages (a type of immune cell), due to reduced activity of a protein called liver X receptor (LXR). This protein is responsible for moving cholesterol out of macrophage cells. When they're full of cholesterol, macrophage cells can generate the plaques that clog arteries. SIRT1 increases LXR activity and the movement of cholesterol out of macrophages and the body by HDL.

The study is published in the Oct. 12 issue of the journal Molecular Cell.

"SIRT1 is an important mediator of cholesterol efflux, and, as such, it's predicted to play a role in the development of age-associated diseases where cholesterol is a contributing factor," senior author Leonard Guarente, professor of biology, said in a prepared statement.

"If you had a drug that could increase expression of SIRT1, that could replicate the effects of calorie restriction. This is not going to replace the need for a healthy lifestyle, but it's a supplement that could potentially make you healthier," Guarente said.

More information

The American Heart Association has more about cholesterol.



-- Robert Preidt



SOURCE: Massachusetts Institute of Technology, news release, Oct. 11, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Long-life genes - A new way to combat cancer…
2. OBESE LIL GIRLS !! SWEAT IT OUT OR U MIGHT BE ASTHAMATIC !!!
3. Anemia Treatment for Cancer Patients Might Not be a Good Idea.
4. Cabbage, cauliflower might contribute to cancer prevention
5. Suicide might be inherited
6. Cleanliness might lead to Asthma
7. Stroke risk might be linked to antibody
8. Change in walking might indicate Dementia
9. Drug might prevent Prostate Cancer Spread
10. Diet might just have an Effect on Breast Cancer
11. Tomatoes Might Inhibit the Development Of Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Conventional wisdom ... of success. In terms of the latter, setting the bar too high can result ... more than just slow progress toward their goal. , Research from PsychTests.com ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Any dentist who has made an ... current process. Many of them do not even offer this ... and high laboratory costs involved. And those who ARE able ... such a high cost that the majority of today,s patients ... Parsa Zadeh , founder of Dental Evolutions Inc. and ...
(Date:6/23/2016)... 23, 2016  In a startling report released today, National ... by lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... of how states are tackling the worst drug crisis in recorded ... – Kentucky , New Mexico ... . Of the 28 failing states, three – Michigan ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data derived ... Assessment of major trends with potential impact on the market ... of market segmentation which comprises of sub markets, regional and ...
Breaking Medicine Technology: