Navigation Links
Long-Life Gene Might Help Lower Cholesterol
Date:10/11/2007

Drugs boosting SIRT1's activity could be valuable, scientists say

THURSDAY, Oct. 11 (HealthDay News) -- A gene already associated with longer life span may also be linked to a pathway that clears cholesterol from the body, say Massachusetts Institute of Technology (MIT) researchers.

They said their finding could help lead to the creation of drugs that lower the risk of cholesterol-related diseases such as atherosclerosis (clogged arteries) and Alzheimer's disease.

The gene, called SIRT1, prevents cholesterol buildup by activating a cellular pathway that flushes cholesterol from the body using high density lipoprotein (HDL or "good" cholesterol), the team explained.

In their research with mice, the MIT team found that low SIRT1 levels resulted in cholesterol buildup in cells such as macrophages (a type of immune cell), due to reduced activity of a protein called liver X receptor (LXR). This protein is responsible for moving cholesterol out of macrophage cells. When they're full of cholesterol, macrophage cells can generate the plaques that clog arteries. SIRT1 increases LXR activity and the movement of cholesterol out of macrophages and the body by HDL.

The study is published in the Oct. 12 issue of the journal Molecular Cell.

"SIRT1 is an important mediator of cholesterol efflux, and, as such, it's predicted to play a role in the development of age-associated diseases where cholesterol is a contributing factor," senior author Leonard Guarente, professor of biology, said in a prepared statement.

"If you had a drug that could increase expression of SIRT1, that could replicate the effects of calorie restriction. This is not going to replace the need for a healthy lifestyle, but it's a supplement that could potentially make you healthier," Guarente said.

More information

The American Heart Association has more about cholesterol.



-- Robert Preidt



SOURCE: Massachusetts Institute of Technology, news release, Oct. 11, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Long-life genes - A new way to combat cancer…
2. OBESE LIL GIRLS !! SWEAT IT OUT OR U MIGHT BE ASTHAMATIC !!!
3. Anemia Treatment for Cancer Patients Might Not be a Good Idea.
4. Cabbage, cauliflower might contribute to cancer prevention
5. Suicide might be inherited
6. Cleanliness might lead to Asthma
7. Stroke risk might be linked to antibody
8. Change in walking might indicate Dementia
9. Drug might prevent Prostate Cancer Spread
10. Diet might just have an Effect on Breast Cancer
11. Tomatoes Might Inhibit the Development Of Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... ... May 26, 2017 , ... Somnoware, a ... portable sleep monitor with its Somnoware Sleep Device Interface (SDI). Somnoware SDI is ... device operations. With this platform, initializing devices and importing studies are just one-click ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... On May ... (AHCA), which narrowly passed the U.S. House on May 4, would result in 23 ... expected under continued implementation of the 2010 Patient Protection and Affordable Care Act (ACA). ...
(Date:5/26/2017)... ... May 26, 2017 , ... Rob Lowe acts as host and helps educate ... is on hiking in American. Viewers can reconnect with America as it explores some ... , Many consumers have looked for an inventive new place for a family vacation, ...
(Date:5/26/2017)... Centennial, Colorado (PRWEB) , ... May 26, 2017 ... ... Exchange will be this year’s recipient of proceeds from its 14th Annual Clays ... Club, 46700 E. County Road 30, Bennett, Colorado. , As part of ...
(Date:5/24/2017)... ... May 24, 2017 , ... Last ... Mary Ellen, hospital employees, and town officials to celebrate the grand opening of ... developed by Rendina as part of its ongoing relationship with RWJBarnabas Health, New ...
Breaking Medicine News(10 mins):
(Date:5/8/2017)... YORK , May 8, 2017 ... the transition from fee for service reimbursement. Black Book ... 2017. 1.       The Market for MIPS ... 77% of physician practices with 3 or more ... Technology Solutions by Q4. "Given the magnitude of the ...
(Date:5/6/2017)... 5, 2017  Hill-Rom Holdings, Inc. (NYSE: HRC), has ... square feet to its Welch Allyn campus. ... to bring more than 100 new jobs to ... has maintained a significant presence for more than 100 ... positions, a large portion of which will be R&D ...
(Date:5/4/2017)... SAN DIEGO , May 4, 2017  The ... Clinical and Scientific Meeting— OBP Medical , a leading ... announced the launch of a new extra-small size and ... ER-SPEC vaginal specula. Already available in small, ... sizes makes OBP Medical,s line of single-use lighted specula ...
Breaking Medicine Technology: