Navigation Links
Long-Life Gene Might Help Lower Cholesterol
Date:10/11/2007

Drugs boosting SIRT1's activity could be valuable, scientists say

THURSDAY, Oct. 11 (HealthDay News) -- A gene already associated with longer life span may also be linked to a pathway that clears cholesterol from the body, say Massachusetts Institute of Technology (MIT) researchers.

They said their finding could help lead to the creation of drugs that lower the risk of cholesterol-related diseases such as atherosclerosis (clogged arteries) and Alzheimer's disease.

The gene, called SIRT1, prevents cholesterol buildup by activating a cellular pathway that flushes cholesterol from the body using high density lipoprotein (HDL or "good" cholesterol), the team explained.

In their research with mice, the MIT team found that low SIRT1 levels resulted in cholesterol buildup in cells such as macrophages (a type of immune cell), due to reduced activity of a protein called liver X receptor (LXR). This protein is responsible for moving cholesterol out of macrophage cells. When they're full of cholesterol, macrophage cells can generate the plaques that clog arteries. SIRT1 increases LXR activity and the movement of cholesterol out of macrophages and the body by HDL.

The study is published in the Oct. 12 issue of the journal Molecular Cell.

"SIRT1 is an important mediator of cholesterol efflux, and, as such, it's predicted to play a role in the development of age-associated diseases where cholesterol is a contributing factor," senior author Leonard Guarente, professor of biology, said in a prepared statement.

"If you had a drug that could increase expression of SIRT1, that could replicate the effects of calorie restriction. This is not going to replace the need for a healthy lifestyle, but it's a supplement that could potentially make you healthier," Guarente said.

More information

The American Heart Association has more about cholesterol.



-- Robert Preidt



SOURCE: Massachusetts Institute of Technology, news release, Oct. 11, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Long-life genes - A new way to combat cancer…
2. OBESE LIL GIRLS !! SWEAT IT OUT OR U MIGHT BE ASTHAMATIC !!!
3. Anemia Treatment for Cancer Patients Might Not be a Good Idea.
4. Cabbage, cauliflower might contribute to cancer prevention
5. Suicide might be inherited
6. Cleanliness might lead to Asthma
7. Stroke risk might be linked to antibody
8. Change in walking might indicate Dementia
9. Drug might prevent Prostate Cancer Spread
10. Diet might just have an Effect on Breast Cancer
11. Tomatoes Might Inhibit the Development Of Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2017)... ... September 23, 2017 , ... Silicon Valley Hair Institute, the leading ... new blog post focused on the ARTAS® hair transplant system and the younger demographic. ... the latest, most technologically sophisticated methods of hair restoration. , “It can be emotionally ...
(Date:9/22/2017)... Plano, TX (PRWEB) , ... September 22, 2017 , ... ... created to strengthen the communities they serve as part of the nationally recognized ‘Agents ... by working closely with nonprofit organizations and community leaders to seek out those who ...
(Date:9/22/2017)... ... 22, 2017 , ... Happy Living’s mission - to improve the health and ... the entertaining and delicious worlds of theatre and wines. , After watching Scott ... to turn his play into a book. The Greener The Grass ( https://www.happyliving.com/books/the-greener-the-grass ) ...
(Date:9/22/2017)... (PRWEB) , ... September 22, 2017 , ... ... host Rob Lowe, explores the world of Alzheimer’s. Alzheimer’s is a disease estimated ... disease. This according to information published by the Alzheimer’s Association, a leading voice ...
(Date:9/22/2017)... ... September 22, 2017 , ... Egg freezing and embryo freezing ... have a slight statistical advantage for live births, frozen eggs offer many advantages, ... women undergoing medical treatment or who are concerned about the decline of their ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... 22, 2017 AVACEN Medical (AVACEN) announced that ... successfully helping those with the widespread pain associated with ... Amanda in Essex, England commented, ... hair, experiencing no sleep at all, tremendous pain, with ... cannot recommend [the AVACEN 100] enough, how this has ...
(Date:9/18/2017)... R.I. , Sept. 18, 2017 /PRNewswire/ ... the fields of bioinformatics and immune engineering, ... a protective avian influenza A (H7N9) vaccine. ... distantly related to seasonal influenza and presents ... rely on prior exposure to be effective. ...
(Date:9/12/2017)... , Sept. 12, 2017  ValGenesis Inc., ... Solutions (VLMS), is pleased to announce the appointment ... member of its Board of Directors and Chairman ... VLMS enables life science companies to manage their ... use of paper in this process. Furthermore, ValGenesis ...
Breaking Medicine Technology: