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Lombardi research teams hone in on treatments for osteosarcoma and Ewing's sarcoma
Date:4/20/2010

, requiring minimal reagents and a higher-throughput format. Data from binding studies will help to predict and direct the design of more potent analogues." - Julie S. Barber-Rotenberg

Authors: Julie S. Barber-Rotenberg, Yali Kong, Nilan Schnure, Sivanesan Dakshanamurthy, Milton L. Brown, Hayriye V. Erkizan, Aykut Uren. and Jeffrey A. Toretsky, from Georgetown Lombardi Comprehensive Cancer Center; Peter Frazier, Cornell University

To be presented: Monday, April 19, 2:00 pm 5:00 pm; Exhibit Hall A-C, Poster Section 28; Board 14


Phage display identifies novel toxic binding peptides for the disordered oncoprotein EWS-FLI1 (Abstract #3412)

EMBARGO: Tuesday, April 20, 2010, 9 AM

Author's summary: "The EWS-FLI1 protein results from a tumor-specific chromosomal translocation and is uniquely expressed in Ewing's Sarcoma Family Tumors (ESFT). EWS-FLI1 is a disordered protein and thus presents opportunities for manipulating protein-protein interactions, some of which will be specific anti-tumor targets. By looking at and identifying various peptides and their cognate proteins, we can investigate the function of EWS-FLI1 in order to improve therapies for ESFT patients. The A1 peptide, which we focused on specifically, appears to directly bind to the EWS-FLI1 protein and lead to cell death in cells with the EWS-FLI1 fusion protein." - Lauren M. Jacobwitz

Authors: Lauren M. Jacobwitz, Hayriye V. Erkizan, Aykut ren, and Jeffrey A. Toretsky, Georgetown Lombardi Comprehensive Cancer Center

To be presented: Tuesday, April 20, 9:00 am 12:00 pm ET; Exhibit Hall A-C, Poster Section 18; Board 13


Small molecule inhibitors of ezrin as anti-metastatic agents in osteosarcoma (Abstract #1550)

EMBARGO: Monday, April 19, 2010; 9:00 am ET

Author's summary: "Our study is focused on developing new therapies for osteosarcoma (OS). OS is a very aggressive cancer of the bone. Death from O
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Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

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