Navigation Links
Lombardi research teams hone in on treatments for osteosarcoma and Ewing's sarcoma
Date:4/20/2010

Washington, DC Most cancers arise from the epithelium, the tissue that lines the body and the organs, but sarcomas come from connective tissue cells, like the bones. At Georgetown Lombardi Comprehensive Cancer Center, research have engaged in a full-court press to develop new therapies to treat osteosarcoma and Ewing's sarcoma, the two most common bone tumors in children, adolescents and young adults.

At the AACR 101st Annual Meeting 2010, they offer new molecular insights into the translocation that causes Ewing's sarcoma, a genetic exchange between chromosomes that results in a fused gene that produces an oncogenic protein. These findings, coupled with use of sophisticated drug design technology, have led to identification of three new targets for potential treatment of this rare cancer. Additionally, researchers have identified two small molecules that have the potential to prevent or treat spread of osteosarcoma, a very aggressive cancer. (Embargoes listed with each abstract summary that follows).

"Scientific studies in the past decade identified very promising molecular targets that play a major role in tumor progression and invasion. With the help of a multidisciplinary team of scientists at Lombardi, we are now focusing on developing small molecules that can hit these targets," says Aykut ren, M.D., assistant professor in the Department of Oncology at Lombardi. "With this truly translational experimental approach, we may be able to optimize our small molecules for clinical trials in the near future."

ABSTRACT SUMMARIES

Targeting of EWS-FLI1 with small molecule YK-4-279 reduces xenograft growth by disruption of disordered protein-protein interactions (abstract #3411)

EMBARGO: Tuesday, April 20, 2010, 9:00 am ET

Author's summary: "Because the oncoprotein that causes the Ewing's sarcoma is so disordered, we reasoned that it might be possible to use a small molecule to target that protein and
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Lombardis Shields leads special journal focused on tobacco research
2. GUMCs Lombardi Hosts Symposium Exploring Future of Cancer Research and Personalized Medicine
3. New research identifies modifiable risk factors for heart disease
4. Nuvo Research announces early redemption of 5% convertible debentures
5. Researcher to track spread of disease, malware and power outages
6. UCSF Researchers Identify Regulator of Human Sperm Cells
7. Octapharma Accepting Applications for Research Grants Through March 31
8. Valentine Tailgate Party for the Girls with Festive Ideas from Beauty Research
9. New Research Shows Genes of Pregnant Women and Their Fetuses Can Increase the Risk of Preterm Labor
10. University of Maryland chemist receives Astellas Award for blindness prevention research
11. Developing a cyberinfrastructure for comparative effectiveness in cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... September 19, 2014 BCC Research reveals ... AND GLOBAL MARKETS , the global market for human ... billion by 2018, with a five-year compound annual growth ... is growing at a steady 3.8% CAGR. , Given ... lower sales, coupled with the incidence of increasing mortality ...
(Date:9/19/2014)... 2014 Singulair, developed by Merck, is ... leukotriene D4 (LTD4). LTD4 belongs to the family of ... cells, including mast cells and eosinophils, and which bind ... determined that there are higher concentrations of Cys-LTs in ... individuals. The production of CysLTs is increased in asthmatics, ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 Follow ... part of the medical imaging market, are engineered to ... developments over the past three decades have expanded the ... barium and iodine based agents used for over half ... and radiopharmaceuticals, imaging agents have witnessed sea changes, revolutionizing ...
(Date:9/19/2014)... 2014 Recent financial data reveled ... increased their sales by 7% in the last quarter ... industry can be used as a bellwether to determine ... This data has been proven to show trends with ... transportation. Other non-trucking data is largely influenced by international ...
(Date:9/19/2014)... September 19, 2014 TMG Health, ... solutions for Health Plans in the Medicare Advantage, ... sponsor a Networking Breakfast Session with featured speaker ... Advisory Practice at Pricewaterhouse Coopers, from 7:45-8:30 a.m. ... 2014 National Conference on Medicare in Washington, D.C. ...
Breaking Medicine News(10 mins):Health News:Global Market for Human Antifungal Therapeutics to Reach Nearly $13.9 Billion in 2018; Over-The-Counter (OTC) Segment Growing At 3.8% CAGR 2Health News:Global Market for Human Antifungal Therapeutics to Reach Nearly $13.9 Billion in 2018; Over-The-Counter (OTC) Segment Growing At 3.8% CAGR 3Health News:Singulair Asthma Market to 2023 – Etiology, Pathophysiology, Diagnosis & Treatment Overview in New Report Available at LifeScienceIndustryResearch.com 2Health News:Singulair Asthma Market to 2023 – Etiology, Pathophysiology, Diagnosis & Treatment Overview in New Report Available at LifeScienceIndustryResearch.com 3Health News:Singulair Asthma Market to 2023 – Etiology, Pathophysiology, Diagnosis & Treatment Overview in New Report Available at LifeScienceIndustryResearch.com 4Health News:New Clinical Applications and Advanced Imaging Capabilities Drive Growth in the Imaging Agents Market, According to New Report by Global Industry Analysts, Inc. 2Health News:New Clinical Applications and Advanced Imaging Capabilities Drive Growth in the Imaging Agents Market, According to New Report by Global Industry Analysts, Inc. 3Health News:New Clinical Applications and Advanced Imaging Capabilities Drive Growth in the Imaging Agents Market, According to New Report by Global Industry Analysts, Inc. 4Health News:LeaseQ Announces Good News For The Truck Leasing Industry As Truck Rentals In The U.S Continues to Gain Traction 2Health News:LeaseQ Announces Good News For The Truck Leasing Industry As Truck Rentals In The U.S Continues to Gain Traction 3Health News:TMG Health To Sponsor Pricewaterhouse Coopers Speaker at AHIP’s National Conference on Medicare 2Health News:TMG Health To Sponsor Pricewaterhouse Coopers Speaker at AHIP’s National Conference on Medicare 3
... Food and Drug Administration (FDA) is asking for comment on ... industry, developed in response to section 1005 of the Food ... RFR is scheduled for implementation on September 8, 2009, and ... Only infant formula is exempt from the RFR requirements. , ...
... YOKNEAM, Israel and PLYMOUTH MEETING, Pa., June 16 On ... for the State of Delaware, granted Galil Medical Ltd.,s motion ... Inc., arising out of Endocare,s alleged breach of the Galil/Endocare ... argument, and ordered that a two-day trial would be held ...
... Point-of-Care Patient Payment Collection Software powered by mPay Gateway ... Systems, Inc., a leading provider of connected healthcare technology ... of NetPay, a web-based application that integrates with NetPracticePM(TM) ... at the point of service when patients are still ...
... - Awards Recognize Outstanding Design Innovation in Casegoods, Seating, Tables ... Steelcase Inc. (NYSE: SCS ), a global ... companies won five Best of NeoCon awards, including two Gold ... and a leading manufacturer of furniture for healthcare environments, won ...
... while Preserving the Designer,s Layout , , TUCSON, Ariz., ... in reading technology, today announced the launch of its ReadSmart ... the iTunes App Store(TM). The apps, available at the iTunes ... books for download that retain the look and design of ...
... UPTON, NY Researchers at the U.S. Department of Energy,s ... x-ray imaging technique that could be developed into a method ... been used to look at tumors in breast tissue and ... is the first to test its ability to visualize a ...
Cached Medicine News:Health News:Reportable Food Registry Draft Guidance Published for Comment by FDA 2Health News:Delaware Chancery Court Grants Galil Medical Ltd.'s Motion for Expedited Proceeding in Suit Against Endocare 2Health News:Noteworthy Medical Systems Introduces NetPay(TM) 2Health News:Steelcase Inc. Receives Five Best of NeoCon Awards and Best Overall Showroom for Nurture at NeoCon 2009 2Health News:Steelcase Inc. Receives Five Best of NeoCon Awards and Best Overall Showroom for Nurture at NeoCon 2009 3Health News:Language Technologies Introduces ReadSmart Edition Apps(TM) for the iPhone(TM) and iPod(R) Touch; Unique Apps Improve Ergonomics of Reading while Retaining Look and Design of Print Books 2Health News:Language Technologies Introduces ReadSmart Edition Apps(TM) for the iPhone(TM) and iPod(R) Touch; Unique Apps Improve Ergonomics of Reading while Retaining Look and Design of Print Books 3Health News:Language Technologies Introduces ReadSmart Edition Apps(TM) for the iPhone(TM) and iPod(R) Touch; Unique Apps Improve Ergonomics of Reading while Retaining Look and Design of Print Books 4Health News:X-rays for early Alzheimer's disease detection 2Health News:X-rays for early Alzheimer's disease detection 3
(Date:9/19/2014)... Sept. 19, 2014  Over 200 runners participated in ... Benefit the Radiation Oncology Institute (ROI), hosted by Radiation ... Gate Park in San Francisco.  "Donations ... CEO of Radiation Business Solutions, "but at this ... over $70,000 for the ROI this year. This surpasses ...
(Date:9/19/2014)... 19, 2014  PCI is pleased to announce ... is a leading provider of Clinical Trial Services ... Wales in the ... expands PCI,s presence in the UK/EU to support ... packaging, storage and distribution capacity, as well as ...
(Date:9/18/2014)... 18, 2014  LABSCO, the leading specialty ... products to hospitals, physician office laboratories and ... distributorship agreement with Sysmex America.  This agreement ... including the Sysmex XS-1000 i ™, Sysmex ... XN-Series Automated Hematology Analyzers. The ...
Breaking Medicine Technology:Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 2Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 3PCI Announces Acquisition Of Biotec 2PCI Announces Acquisition Of Biotec 3PCI Announces Acquisition Of Biotec 4PCI Announces Acquisition Of Biotec 5PCI Announces Acquisition Of Biotec 6LABSCO Renews Sysmex Distributorship Agreement 2LABSCO Renews Sysmex Distributorship Agreement 3
... Terumo Heart, Inc. announced,today that it ... the European,Association of Cardio-Thoracic Surgeons (EACTS) meeting ... ) (Logo: http://www.newscom.com/cgi-bin/prnh/20070227/CLTU043LOGO ) ... Trial results for the DuraHeart(TM),Left Ventricular Assist ...
... analysis reported,at the American Society for Bone and ... decreased clinical fracture risk by 50% over,three years ... women with,osteoporosis who had suffered a previous hip ... evaluated the combined incidence,of vertebral and nonvertebral clinical ...
Cached Medicine Technology:Terumo Heart Reports Summary of DuraHeart(TM) LVAS Clinical Trial Results 2Risedronate Reduced Risk of Fracture Among Osteoporotic Postmenopausal Women with History of Hip Fracture 2Risedronate Reduced Risk of Fracture Among Osteoporotic Postmenopausal Women with History of Hip Fracture 3Risedronate Reduced Risk of Fracture Among Osteoporotic Postmenopausal Women with History of Hip Fracture 4
Reusable, stainless steel trephine with handle....
Reusable, stainless steel trephine with handle....
Each handle is designed to fit a specific trephine size. For use in performing free-hand uniform donor buttons....
Each handle is designed to fit a specific trephine size. For use in performing free-hand uniform donor buttons....
Medicine Products: