Navigation Links
Lombardi research: Robotic radiosurgery offers palliative care for hilar lung tumors

Washington, DC Patients report decreased pain and improved breathing following treatment of their hilar tumors with robotic radiosurgery, but researchers say the therapy falls short of improving survival. Still, the study, conducted by researchers at Georgetown Lombardi Comprehensive Cancer Center and presented today at the annual meeting of the American College of Chest Physicians in Vancouver, BC, represents the first of its kind to document the use of radiosurgery for hilar tumors and presents a novel therapy option.

For the study, researchers reviewed the medical records of patients diagnosed with inoperable primary and metastatic hilar lung tumors. Hilar tumors abut or invade the mainstem bronchus. All the patients in the study were treated with five courses (30 to 40 Gy in 5 fractions) of radiotherapy using CyberKnife. Imaging studies with a combined PET/CT scan were performed at three and six-month follow-up intervals to track tumor progression.

The record review included 24 patients -- four with inoperable primary hilar lung tumors and 20 with hilar tumors that had spread there from other primary sites. The mean radiation dose administered to the esophagus was 27 Gy (ranging from 11 to 40 Gy) and mean radiation dose administered to the lung was 45 Gy (ranging from 30 to 50 GY).

At one-year, the overall survival was 61 percent and local control (ability to keep the tumor from growing) was 71 percent.The review found that most deaths were attributed to the spread of the patients' cancers. However, there was one death that was attributed to an opening in the mainstem bronchus in a patient who was previously stented.

While no uniform data was collected from patients about quality of life at the time of their treatment, the study's lead author says the patient records reflect comments made by patients about their symptoms.

"Patients reported improvement with coughing, breathing, and they reported less pain," said Brian Collins, MD, a radiation oncologist with Lombardi and lead author of the study.

"Our study suggests that CyberKnife is a palliative treatment option for hilar lung tumors," explains Collins. "We'd like to investigate outcomes with increased radiation doses to see if we can improve local control and overall survival rates. And we'd like to study the impact of administering a drug to make the tumors more sensitive to radiation.

"This is an important first step that gives us a new option to treat potentially morbid hilar tumor," Collins concludes. "Future studies would likely involve drugs to make the tumor more sensitive to radiation."


Contact: Karen Mallet
Georgetown University Medical Center

Related medicine news :

1. Susan G. Komen for the Cure awards grant to Lombardis V. Craig Jordan
2. Lombardi research teams hone in on treatments for osteosarcoma and Ewings sarcoma
3. GUMCs Lombardi Hosts Symposium Exploring Future of Cancer Research and Personalized Medicine
4. Most Americans Back Embryonic Stem Cell Research: Poll
5. Womens health research: IOM releases progress report Sept. 23
6. Health care research: $1.6 million in new funding for University of Montreal
7. Research: Schwartz Center Rounds encourage compassionate health care and better teamwork
8. Implementing comparative effectiveness research: Lessons from the mammography screening controversy
9. Research: Major breakthrough will revolutionize the screening and treatment of genetic diseases
10. National Event Addresses Breakthroughs in Crohn's & Colitis Research: National Expert & Researcher Answers Key Questions on Interactive Webcast/Teleconference
11. Research: How you think about your age may affect how you age
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... According to an article ... University of Toronto and the University of British Columbia suggested that laws requiring bicyclists ... The article explains that part of the reason for the controversial conclusion is that, ...
(Date:11/27/2015)... ... , ... The rapid speed at which Americans are aging ... is needed, especially with Alzheimer’s, dementia and other cognitive conditions becoming more prevalent. ... part of this equation: 80 percent of medical care occurs in the home, ...
(Date:11/27/2015)... ... November 27, 2015 , ... An inventor, ... to dispense prescription medications at home, so he invented the patent-pending ELECTRONIC M.D. ... dispense prescription medications. In doing so, it could help to prevent potential overdose ...
(Date:11/27/2015)... ... November 27, 2015 , ... Lizzie’s Lice Pickers just ... is offering customers 10% off of their purchase of lice treatment product. In addition, ... price. According to a company spokesperson. “Finding lice is a sure way to ruin ...
(Date:11/27/2015)... ... 2015 , ... ProSidebar: Fashion is a set of 30 kinetic ... Fasion, video editors can easily add an informative sidebar to any FCPX production. ... presets featuring self-animating drop zones, lines, bars, and text with the ease of FCPX's ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... Netherlands , November 26, 2015 ... A new combination approach blends immunotherapy with Bremachlorin-photodynamic ... A new combination approach blends immunotherapy with Bremachlorin-photodynamic therapy ... A new combination approach blends immunotherapy with Bremachlorin-photodynamic therapy ... Netherlands has found that immunotherapy can be ...
(Date:11/26/2015)... --> --> ... find optimal contrast weighting of MRI for patients with ... a research agreement with SyntheticMR in order to use SyMRI ... is possible to generate multiple contrast images from a single ... left, thus making it possible to both fine tune images ...
(Date:11/26/2015)... -- 3D bioprinting market is expected to ... report by Grand View Research Inc. Rising prevalence of chronic ... transplantation is expected to boost the market growth, as 3D ... --> 3D bioprinting market is expected to ... report by Grand View Research Inc. Rising prevalence of chronic ...
Breaking Medicine Technology: