Navigation Links
Lombardi research: Robotic radiosurgery offers palliative care for hilar lung tumors
Date:11/2/2010

Washington, DC Patients report decreased pain and improved breathing following treatment of their hilar tumors with robotic radiosurgery, but researchers say the therapy falls short of improving survival. Still, the study, conducted by researchers at Georgetown Lombardi Comprehensive Cancer Center and presented today at the annual meeting of the American College of Chest Physicians in Vancouver, BC, represents the first of its kind to document the use of radiosurgery for hilar tumors and presents a novel therapy option.

For the study, researchers reviewed the medical records of patients diagnosed with inoperable primary and metastatic hilar lung tumors. Hilar tumors abut or invade the mainstem bronchus. All the patients in the study were treated with five courses (30 to 40 Gy in 5 fractions) of radiotherapy using CyberKnife. Imaging studies with a combined PET/CT scan were performed at three and six-month follow-up intervals to track tumor progression.

The record review included 24 patients -- four with inoperable primary hilar lung tumors and 20 with hilar tumors that had spread there from other primary sites. The mean radiation dose administered to the esophagus was 27 Gy (ranging from 11 to 40 Gy) and mean radiation dose administered to the lung was 45 Gy (ranging from 30 to 50 GY).

At one-year, the overall survival was 61 percent and local control (ability to keep the tumor from growing) was 71 percent.The review found that most deaths were attributed to the spread of the patients' cancers. However, there was one death that was attributed to an opening in the mainstem bronchus in a patient who was previously stented.

While no uniform data was collected from patients about quality of life at the time of their treatment, the study's lead author says the patient records reflect comments made by patients about their symptoms.

"Patients reported improvement with coughing, breathing, and they reported less pain," said Brian Collins, MD, a radiation oncologist with Lombardi and lead author of the study.

"Our study suggests that CyberKnife is a palliative treatment option for hilar lung tumors," explains Collins. "We'd like to investigate outcomes with increased radiation doses to see if we can improve local control and overall survival rates. And we'd like to study the impact of administering a drug to make the tumors more sensitive to radiation.

"This is an important first step that gives us a new option to treat potentially morbid hilar tumor," Collins concludes. "Future studies would likely involve drugs to make the tumor more sensitive to radiation."


'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Related medicine news :

1. Susan G. Komen for the Cure awards grant to Lombardis V. Craig Jordan
2. Lombardi research teams hone in on treatments for osteosarcoma and Ewings sarcoma
3. GUMCs Lombardi Hosts Symposium Exploring Future of Cancer Research and Personalized Medicine
4. Most Americans Back Embryonic Stem Cell Research: Poll
5. Womens health research: IOM releases progress report Sept. 23
6. Health care research: $1.6 million in new funding for University of Montreal
7. Research: Schwartz Center Rounds encourage compassionate health care and better teamwork
8. Implementing comparative effectiveness research: Lessons from the mammography screening controversy
9. Research: Major breakthrough will revolutionize the screening and treatment of genetic diseases
10. National Event Addresses Breakthroughs in Crohn's & Colitis Research: National Expert & Researcher Answers Key Questions on Interactive Webcast/Teleconference
11. Research: How you think about your age may affect how you age
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... PITTSBURGH, PA (PRWEB) , ... December 02, 2016 , ... ... or struggling through rehabilitation of an injury, patients must find the one that works ... for his pain, he created a machine that worked and decided to share it ...
(Date:12/2/2016)... ... 2016 , ... CloudLIMS.com, a class-leading provider of Laboratory Management ... Lite helps biobanks, clinical, research and testing laboratories keep track of their biospecimens, ... is a faster and a more efficient product, allowing batch processing of data, ...
(Date:12/2/2016)... ... December 02, 2016 , ... Yisrayl Hawkins, at The House of Yahweh in ... fits into Bible Prophecy. Yisrayl says this generation, known as the Last Generation, started ... how the details line up exactly with Bible Prophecy – a protected way for ...
(Date:12/2/2016)... ... December 02, 2016 , ... Date aired: ... of Type 2 Diabetes: The Owner’s Manual, http://realtimepressrelease.com/press-releases-tagged-with/daryl-wein , Sharon ... of Water, Global Climate Change and Your Health radio program syndicated on Voice ...
(Date:11/30/2016)... ... November 30, 2016 , ... Standard Process, Inc. ... annual ranking and recognition of the largest closely held companies headquartered in Wisconsin. ... 2008-2016. In addition, Standard Process was awarded the Talent Award for providing outstanding ...
Breaking Medicine News(10 mins):
(Date:11/30/2016)... 2016 Research and Markets has announced the ... 2017 - MedCore" report to their offering. ... , , The cerebrospinal ... In healthy individuals, it is circulated though the brain and its ventricles, ... amount of CSF surrounding the brain changes significantly. ...
(Date:11/30/2016)... Research and Markets has announced the addition of the ... their offering. ... Detachable coil embolization is a minimally invasive method ... embolization treatment of cerebral aneurysms is less invasive and requires less recovery ... wall of an artery in the brain. This area bulges in the ...
(Date:11/30/2016)... 2016 Varian Medical Systems (NYSE: ... JUST Company in the Healthcare Equipment and Services industry, ... inaugural "JUST 100 List." The rankings are based on ... conducted on attitudes towards corporate behavior, involving 50,000 Americans ... U.S companies against their peers within 32 major industries. ...
Breaking Medicine Technology: