Navigation Links
Localized Breast Cancer Cells Have Potential to Spread
Date:1/4/2008

Finding supports the use of radiation after early-stage disease is removed, researchers say

FRIDAY, Jan. 4 (HealthDay News) -- Early breast cancer tumors that have not yet spread contain cells with a predisposition to migrate to new tissue, a new study finds.

So, just because a cancer has not yet spread doesn't mean its cells lack the ability or inclination to do so, warned researchers at the Salk Institute for Biological Studies in La Jolla, Calif. They added that there is also no evidence to suggest that these cells correlate with a positive or negative health outcome for women with breast cancer.

"This is an exciting finding, because it suggests that cells might acquire migratory properties much earlier than expected," senior author Tony Hunter, a professor in the Molecular and Cell Biology Laboratory at the institute, said in a prepared statement.

Self-screening for breast cancer, regular doctor's visits and mammograms have all made it possible to identify breast cancer tumors in their early stages. When identified early, the cancer cells usually are within the confines of a milk duct, the most common origin of breast cancer tumors.

Removal of the small tumor and surrounding tissue, called a lumpectomy, is the standard treatment for this early stage of breast cancer. The question of whether women should also have radiation treatment to address any stray cancer cells has been hotly debated, partly because approximately 16 percent of these patients will see their cancer return within five years.

According to the researchers, the identification of cells that could spread, called motile cells, supports the need for radiation, which is usually determined by tumor size.

The research team studied breast cancer in the lab by allowing breast tissue to grow under observation. The researchers also turned on a series of chemical signals, called the ERK1/2 MAP kinase pathway, that is often active during tumor growth. They then watched as breast cancer cells began to grow and become more aggressive.

The lab setting limited the spreading of the cancer cells, but the researchers interpreted the activity of the cells to indicate a potential for spread.

Writing in the current edition of The Journal of Cell Biology, the researchers said the next step is to identify biological markers to help oncologists diagnose patients who are at higher risk of metastasis.

More information

To learn more about breast cancer, visit the American Cancer Society.



-- Madeline Vann



SOURCE: Salk Institute for Biological Studies, news release, Dec. 31, 2007


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Ultrasound Treats Localized Prostate Cancer
2. Infection outbreaks on teeth can cause alopecia areata or localized hair loss
3. Susan G. Komen for the Cure, Ryan Community Health Centers, Breast Cancer Survivors Call on New York State to Expand Breast Cancer Screening, Treatment Programs
4. ASPS Studies Re-Evaluate Psychological Benefits and Health Concerns of Silicone Breast Implants
5. Breast Cancer Gene Might Extend Ovarian Cancer Survival
6. Bevacizumab found to improve survival for patients with advanced breast cancer
7. Class of Chemotherapy Drugs Helps Certain Breast Cancer Patients
8. Chemotherapy and tamoxifen reduce risk of second breast cancer
9. Anthracyclines improve survival in HER2-positive breast cancer patients
10. Breast cancer gene mutation more common in Hispanic, young black women, Stanford/NCCC study finds
11. Ireland Cancer Center researcher finds standard treatment for breast cancer not followed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 2016 , ... To succeed under value-based payments, healthcare providers ... how to move forward, given the need to sustain current operations. PYA has ... an organization’s specific needs. , PYA Principal Martie Ross states, “Healthcare providers want ...
(Date:6/24/2016)... Brooklyn, New York (PRWEB) , ... June 24, 2016 , ... ... medical marijuana patients optimize the ingestion of their medication by matching users with high ... allows users to compare pieces with no commitment. , Inhale was founded by two ...
(Date:6/24/2016)... ... ... Dr. Seema Daulat, a native Texan and University of Texas at Austin ... July 13, 2016. , Dr. Daulat earned her Doctorate of Medicine (MD) at The ... the Agape Clinic serving Dallas’ underprivileged community. , Following medical school, Dr. Daulat completed ...
(Date:6/23/2016)... Los Angeles, CA (PRWEB) , ... June 23, 2016 , ... ... being conducted that may expose a possible link between head and neck cancer in ... individuals participating in the study were evaluated based on whether they had gum disease, ...
(Date:6/23/2016)... ... ... The Mechille Wilson Agency, a Texas-based insurance company that provides coverage to hundreds ... a charity drive to assist a student to be chosen from the local area. ... be presented to the chosen student to help with the growing costs of tuition, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Bracket , a leading clinical ... generation clinical outcomes platform, Bracket eCOA (SM) 6.0, at ... 26 – 30, 2016 in Philadelphia , ... Outcome Assessment product of its kind to fully integrate with ... Bracket eCOA 6.0 is a flexible platform for electronic clinical ...
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
(Date:6/23/2016)... 2016 Revolutionary technology includes multi-speaker ... , industry leaders in advanced audiology and hearing aid ... Opn ™, the world,s first internet connected hearing aid ... devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) ... of ,world firsts,: , TwinLink™ - the ...
Breaking Medicine Technology: