Navigation Links
Localized Breast Cancer Cells Have Potential to Spread

Finding supports the use of radiation after early-stage disease is removed, researchers say

FRIDAY, Jan. 4 (HealthDay News) -- Early breast cancer tumors that have not yet spread contain cells with a predisposition to migrate to new tissue, a new study finds.

So, just because a cancer has not yet spread doesn't mean its cells lack the ability or inclination to do so, warned researchers at the Salk Institute for Biological Studies in La Jolla, Calif. They added that there is also no evidence to suggest that these cells correlate with a positive or negative health outcome for women with breast cancer.

"This is an exciting finding, because it suggests that cells might acquire migratory properties much earlier than expected," senior author Tony Hunter, a professor in the Molecular and Cell Biology Laboratory at the institute, said in a prepared statement.

Self-screening for breast cancer, regular doctor's visits and mammograms have all made it possible to identify breast cancer tumors in their early stages. When identified early, the cancer cells usually are within the confines of a milk duct, the most common origin of breast cancer tumors.

Removal of the small tumor and surrounding tissue, called a lumpectomy, is the standard treatment for this early stage of breast cancer. The question of whether women should also have radiation treatment to address any stray cancer cells has been hotly debated, partly because approximately 16 percent of these patients will see their cancer return within five years.

According to the researchers, the identification of cells that could spread, called motile cells, supports the need for radiation, which is usually determined by tumor size.

The research team studied breast cancer in the lab by allowing breast tissue to grow under observation. The researchers also turned on a series of chemical signals, called the ERK1/2 MAP kinase pathway, that is often active during tumor growth. They then watched as breast cancer cells began to grow and become more aggressive.

The lab setting limited the spreading of the cancer cells, but the researchers interpreted the activity of the cells to indicate a potential for spread.

Writing in the current edition of The Journal of Cell Biology, the researchers said the next step is to identify biological markers to help oncologists diagnose patients who are at higher risk of metastasis.

More information

To learn more about breast cancer, visit the American Cancer Society.

-- Madeline Vann

SOURCE: Salk Institute for Biological Studies, news release, Dec. 31, 2007

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Ultrasound Treats Localized Prostate Cancer
2. Infection outbreaks on teeth can cause alopecia areata or localized hair loss
3. Susan G. Komen for the Cure, Ryan Community Health Centers, Breast Cancer Survivors Call on New York State to Expand Breast Cancer Screening, Treatment Programs
4. ASPS Studies Re-Evaluate Psychological Benefits and Health Concerns of Silicone Breast Implants
5. Breast Cancer Gene Might Extend Ovarian Cancer Survival
6. Bevacizumab found to improve survival for patients with advanced breast cancer
7. Class of Chemotherapy Drugs Helps Certain Breast Cancer Patients
8. Chemotherapy and tamoxifen reduce risk of second breast cancer
9. Anthracyclines improve survival in HER2-positive breast cancer patients
10. Breast cancer gene mutation more common in Hispanic, young black women, Stanford/NCCC study finds
11. Ireland Cancer Center researcher finds standard treatment for breast cancer not followed
Post Your Comments:
(Date:11/25/2015)... , ... November 25, 2015 , ... ... for all, Water For Empowerment ™ attracts volunteers together who want to ... by empowering women as key stakeholders in the process. The non-profit launched its ...
(Date:11/25/2015)... ... 2015 , ... TyloHelo Inc , North America’s largest ... accessories help improve the bather experience in the sauna, and the accessories selected ... purist looking for simplicity in design to accessories that encourage a greater expression ...
(Date:11/25/2015)... ... November 25, 2015 , ... For the first time, Vitalalert is donating ... Beat ” campaign. The partnership between the two groups began in 2014 with Vitalalert ... cause. , MAP International was founded in 1954 and is an international Christian-based health ...
(Date:11/25/2015)... ... 2015 , ... On November 25, 2015, officials of Narconon Arrowhead , ... release of a new cutting edge recovery program that has been 50 years in ... and alcohol-addicted individuals with the purpose to free addicts from the symptoms and negative ...
(Date:11/25/2015)... ... 2015 , ... Smiles by Stevens is pleased to announce the ... While many patients are aware of the benefits of Botox® in the treatment of ... suffering with discomfort, soreness, and pain as a result of Jaw Tension, TMJ (temporo-mandibular ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 3D bioprinting ... 2022, according to a new report by Grand View Research ... Disease (CKD) which demands kidney transplantation is expected to boost ... effective substitute for organ transplantation. --> 3D bioprinting ... 2022, according to a new report by Grand View Research ...
(Date:11/26/2015)... 2015 ) ... "2016 Future Horizons and Growth Strategies in ... Supplier Shares, Country Segment Forecasts, Competitive Intelligence, ... --> ) has announced ... Horizons and Growth Strategies in the French ...
(Date:11/26/2015)... , November 26, 2015 ... of the "2016 Future Horizons and ... Abuse Testing Market: Supplier Shares, Country Segment ... to their offering. --> ... "2016 Future Horizons and Growth Strategies ...
Breaking Medicine Technology: