Navigation Links
Localized Breast Cancer Cells Have Potential to Spread
Date:1/4/2008

Finding supports the use of radiation after early-stage disease is removed, researchers say

FRIDAY, Jan. 4 (HealthDay News) -- Early breast cancer tumors that have not yet spread contain cells with a predisposition to migrate to new tissue, a new study finds.

So, just because a cancer has not yet spread doesn't mean its cells lack the ability or inclination to do so, warned researchers at the Salk Institute for Biological Studies in La Jolla, Calif. They added that there is also no evidence to suggest that these cells correlate with a positive or negative health outcome for women with breast cancer.

"This is an exciting finding, because it suggests that cells might acquire migratory properties much earlier than expected," senior author Tony Hunter, a professor in the Molecular and Cell Biology Laboratory at the institute, said in a prepared statement.

Self-screening for breast cancer, regular doctor's visits and mammograms have all made it possible to identify breast cancer tumors in their early stages. When identified early, the cancer cells usually are within the confines of a milk duct, the most common origin of breast cancer tumors.

Removal of the small tumor and surrounding tissue, called a lumpectomy, is the standard treatment for this early stage of breast cancer. The question of whether women should also have radiation treatment to address any stray cancer cells has been hotly debated, partly because approximately 16 percent of these patients will see their cancer return within five years.

According to the researchers, the identification of cells that could spread, called motile cells, supports the need for radiation, which is usually determined by tumor size.

The research team studied breast cancer in the lab by allowing breast tissue to grow under observation. The researchers also turned on a series of chemical signals, called the ERK1/2 MAP kinase pathway, that is often active during tumor growth. They then watched as breast cancer cells began to grow and become more aggressive.

The lab setting limited the spreading of the cancer cells, but the researchers interpreted the activity of the cells to indicate a potential for spread.

Writing in the current edition of The Journal of Cell Biology, the researchers said the next step is to identify biological markers to help oncologists diagnose patients who are at higher risk of metastasis.

More information

To learn more about breast cancer, visit the American Cancer Society.



-- Madeline Vann



SOURCE: Salk Institute for Biological Studies, news release, Dec. 31, 2007


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Ultrasound Treats Localized Prostate Cancer
2. Infection outbreaks on teeth can cause alopecia areata or localized hair loss
3. Susan G. Komen for the Cure, Ryan Community Health Centers, Breast Cancer Survivors Call on New York State to Expand Breast Cancer Screening, Treatment Programs
4. ASPS Studies Re-Evaluate Psychological Benefits and Health Concerns of Silicone Breast Implants
5. Breast Cancer Gene Might Extend Ovarian Cancer Survival
6. Bevacizumab found to improve survival for patients with advanced breast cancer
7. Class of Chemotherapy Drugs Helps Certain Breast Cancer Patients
8. Chemotherapy and tamoxifen reduce risk of second breast cancer
9. Anthracyclines improve survival in HER2-positive breast cancer patients
10. Breast cancer gene mutation more common in Hispanic, young black women, Stanford/NCCC study finds
11. Ireland Cancer Center researcher finds standard treatment for breast cancer not followed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... DC (PRWEB) , ... April 24, 2017 , ... The ... recognized during ATA 2017: Telehealth 2.0 — the American Telemedicine Association’s annual conference, on ... Santana Telehealth Project for using telemedicine to improve the lives of the poor and ...
(Date:4/24/2017)... IL (PRWEB) , ... April 24, 2017 , ... Today, Bright Pink , a ... in young women, names a new CEO. , Bright Pink is proud to announce ... she would be moving to a new role as Chairman of the Board and ...
(Date:4/24/2017)... Raton, Florida (PRWEB) , ... April 24, 2017 ... ... develops a variety of unique liquid food supplements, announced its popular products are ... nutritional products. , ALP Nutrition® prioritizes the use of premium natural ingredients ...
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... ... (CDC), rising prescription opioid overdose deaths now claim the lives of 62 Americans ... civil case filings against drug manufacturers, distributors, pharmacies and prescribers by more than ...
(Date:4/24/2017)... ... 24, 2017 , ... As a former supermodel known for her timeless beauty, ... for single women is that she put all the words in her new book, ... insight, personal experiences and sparkling sense of humor have inspired her to write a ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... 20, 2017 Research and Markets has ... Market Share, Application Analysis, Regional Outlook, Growth Trends, Key Players, ... their offering. ... pharmacogenomics market was valued at US$ 7,167.6 Mn in 2015, ... expanding at a CAGR of 5.6% from 2016 to 2024. ...
(Date:4/20/2017)... , April 20, 2017 Research and ... Pharmaceutical Contract Manufacturing Services Market Analysis By Service (Manufacturing, Research), ... Forecasts, 2014 - 2025" report to their offering. ... The Latin American pharmaceutical ... billion by 2025 Low drug registration cost in ...
(Date:4/19/2017)... , April 19, 2017 The Mobile X-Ray product ... a healthy CAGR during the forecast period Mobile ... the global digital mobile X-Ray devices market, which is estimated ... 2017, expanding at a CAGR of 7% over the forecast ... opportunity of more than US$ 100 Mn in 2017 over ...
Breaking Medicine Technology: