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Living donor exchange poses new option for liver transplantation
Date:4/1/2010

nt. However, cultural obstacles to the idea exist. Lead researcher of the Korean team, Sung-Gyu Lee, M.D., explained, "The establishment of a paired exchange living-donor kidney transplantation program in Korea suggested that a similar program for LDLT would be acceptable in our country. In other Asian countries, such as Japan, where the availability of deceased donors is much less than in Korea, these programs may not be generally accepted." In Japan, the concept of giving or receiving organs to or from unrelated donors is not an accepted practice.

The donor exchange practice also raises ethical concerns, specifically, that all donors involved must understand the potential risks to their own health, as well as the possibility that while the recipient of their donated organ may survive, their own relative, for whose benefit they have entered into the exchange program, may experience an adverse outcome.

Chung Mau Lo, M.D., lead researcher of the Hong Kong team, commented, "Prior psychological evaluation and preparation in anticipation of possible scenarios are crucial in minimizing donor difficulties when confronting such mishaps. In fact, the donor should have a mindset that only with another compatible but unrelated donor donating, can the related recipient have an opportunity to undergo the LDLT." Furthermore, to ensure that all donors comply regardless of the surgical outcome, the LDLT operations must be conducted simultaneously, which may raise logistical issues.

Both transplant centers achieved high success rates, with all donors and all but one recipient making complete recoveries. Both teams conclude exchange donor programs for LDLT are a viable alternative to donor ABO-incompatibility and should become accepted in countries where paired exchange programs for living-donor kidney transplantation have already been established.


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Contact: Dawn Peters
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Wiley-Blackwell
Source:Eurekalert

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