Navigation Links
Living antibiotic effective against Salmonella
Date:6/27/2011

Scientists have tested a predatory bacterium Bdellovibrio against Salmonella in the guts of live chickens. They found that it significantly reduced the numbers of Salmonella bacteria and, importantly, showed that Bdellovibrio are safe when ingested.

The research was funded by the Biotechnology and Biological Sciences Research Council, carried out by Professor Liz Sockett's team at The University of Nottingham, with Dr Robert Atterbury and Professor Paul Barrow at the University of Nottingham Vet School; and published in the journal Applied and Environmental Microbiology.

Researcher Dr Laura Hobley said "Bdellovibrio has the potential to be used as a living antibiotic against some major human and animal pathogens, such as E. coli and other so-called Gram-negative bacteria."

Previous studies have shown that Bdellovibrio is very effective at invading and killing other bacterial cells in a test tube. It looks likely to provide an alternative to antibiotic medicines at a time when bacterial resistance is a significant problem to human and animal health.

Dr Hobley continued "We think that Bdellovibrio could be particularly useful as a topical treatment for wounds or foot rots but we wanted to know what might happen if it is ingested either deliberately as a treatment, or by accident."

Salmonella likes to grow in the guts of poultry and other animals and can cause food poisoning in humans. In lab experiments Bdellovibrio can kill Salmonella by breaking into the cells and destroying them from the inside. This research shows that it also works inside the gut of a bird and is safe, not harming them or changing their behaviour.

Bdellovibrio reduced the numbers of Salmonella by 90% and the birds remained healthy, grew well, and were generally in good condition.

"We concluded that Bdellovibrio aren't long lived in the bird guts they had a strong effect for about 48 hours, which dropped off after this time. If we were to use this method to completely rid the birds of Salmonella, we might have to test a program of multiple dosing. But the point of this study was really to ensure that Bdellovibrio is safe and effective when ingested," said Dr Hobley.

Professor Douglas Kell, Chief Executive, BBSRC said "Once we have understood the fundamental nature of an extraordinary organism such as Bdellovibrio, it makes sense that we should look at potential uses for it. The impact of bacterial infections on human and animal health is significant and since antibiotic resistance is a major issue, alternatives from nature may become increasingly important."


'/>"/>

Contact: Mike Davies
mike.davies@bbsrc.ac.uk
44-179-341-4694
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Related medicine news :

1. Bariatricfurnishings.com Launches Unique Eco-friendly Seating for Health Care, Hospitality, Assisted Living Centers, and Home Use at Competitive Prices
2. Maximized Living Named as Exclusive Chiropractic Partner of USA Weightlifting
3. Greenwala and PETCO Announce Healthy Living, Healthy Pet Social Media Campaign
4. RetireSafe Survey Says Seniors Are Struggling With Increased Costs Without an Increased Social Security Cost of Living Adjustment
5. Register Online for this Year's Horst Senior Living Conference on April 8 Featuring Keynote Speaker and Senior Housing Expert Jim Moore
6. Nurtur Acquires ActivHealth and Wellness by Choice; Gains Exclusive Partnership with Duke University Center for Living
7. Healthy Aging Global Leader Broadens Patient Exercise/Nutrition Success With Online Living Site
8. iTable Debuts at CeBIT 2010 to Revolutionize Your Living Room
9. KID HEALTHY-Steps to Healthy Living Kicks Off 2010 Campaign to Make Southern California Kids and Families Healthier
10. Regence Invests in Kinetix Living Corp.
11. Wyndemere Senior Living Community Acquired by Life Care Services
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... Mediaplanet is ... Wound Care" campaign in USA Today, which will educate readers on how to take ... the campaign, a large focus is placed on melanoma. Dancing with the Stars professional, ...
(Date:5/26/2017)... Clara, Calif. (PRWEB) , ... May 26, 2017 ... ... announces the integration of the CareFusion NOX-T3 portable sleep monitor with its Somnoware ... provides a consistent, browser-based interface for diagnostic device operations. With this platform, initializing ...
(Date:5/26/2017)... , ... May 26, 2017 , ... After raising nearly ... Top gadget will continue to be available at a discounted crowdfunding price on ... stress wherever they are, I also wanted to bring a fidget toy to the ...
(Date:5/26/2017)... , ... May 26, 2017 , ... “When the Stars ... Home” is the creation of published author Laura Weigel Douglas, an avid reader who ... in a house that sometimes feels like Green Hills Adventure Camp. She couldn’t be ...
(Date:5/26/2017)... ... , ... Water damage to the flooring of several classrooms at The Fort ... with a number of critical issues to address before students could return to classes. ... little or no disruption to class schedules. Second, the project had to comply with ...
Breaking Medicine News(10 mins):
(Date:5/11/2017)... 11, 2017  Thornhill Research Inc. ( ... an $8,049,024 USD five-year, firm-fixed-priced, indefinite-quantity/indefinite-delivery contract by ... Commercial Corporation (CCC) ( Ottawa, Ontario, Canada ... administer general anesthesia to patients requiring emergency medical ... US Marine Corps have been a longtime partner ...
(Date:5/10/2017)... , May 10, 2017 Radiology has become ... its costs have also spiraled to the number one ... to radiology than ever before as the most complete ... a patient with lower back pain an MRI may ... reason for pain, resulting in entirely different treatment protocols.  ...
(Date:5/9/2017)... , May 9, 2017  Oramed Pharmaceuticals Inc. ... a clinical-stage pharmaceutical company focused on the development ... the Canadian Intellectual Property Office has granted Oramed ... Administration of Exenatide". The patent covers Oramed,s invention ... GLP-1 is an incretin hormone that stimulates ...
Breaking Medicine Technology: