Navigation Links
Living antibiotic effective against Salmonella
Date:6/27/2011

Scientists have tested a predatory bacterium Bdellovibrio against Salmonella in the guts of live chickens. They found that it significantly reduced the numbers of Salmonella bacteria and, importantly, showed that Bdellovibrio are safe when ingested.

The research was funded by the Biotechnology and Biological Sciences Research Council, carried out by Professor Liz Sockett's team at The University of Nottingham, with Dr Robert Atterbury and Professor Paul Barrow at the University of Nottingham Vet School; and published in the journal Applied and Environmental Microbiology.

Researcher Dr Laura Hobley said "Bdellovibrio has the potential to be used as a living antibiotic against some major human and animal pathogens, such as E. coli and other so-called Gram-negative bacteria."

Previous studies have shown that Bdellovibrio is very effective at invading and killing other bacterial cells in a test tube. It looks likely to provide an alternative to antibiotic medicines at a time when bacterial resistance is a significant problem to human and animal health.

Dr Hobley continued "We think that Bdellovibrio could be particularly useful as a topical treatment for wounds or foot rots but we wanted to know what might happen if it is ingested either deliberately as a treatment, or by accident."

Salmonella likes to grow in the guts of poultry and other animals and can cause food poisoning in humans. In lab experiments Bdellovibrio can kill Salmonella by breaking into the cells and destroying them from the inside. This research shows that it also works inside the gut of a bird and is safe, not harming them or changing their behaviour.

Bdellovibrio reduced the numbers of Salmonella by 90% and the birds remained healthy, grew well, and were generally in good condition.

"We concluded that Bdellovibrio aren't long lived in the bird guts they had a strong effect for about 48 hours, which dropped off after this time. If we were to use this method to completely rid the birds of Salmonella, we might have to test a program of multiple dosing. But the point of this study was really to ensure that Bdellovibrio is safe and effective when ingested," said Dr Hobley.

Professor Douglas Kell, Chief Executive, BBSRC said "Once we have understood the fundamental nature of an extraordinary organism such as Bdellovibrio, it makes sense that we should look at potential uses for it. The impact of bacterial infections on human and animal health is significant and since antibiotic resistance is a major issue, alternatives from nature may become increasingly important."


'/>"/>

Contact: Mike Davies
mike.davies@bbsrc.ac.uk
44-179-341-4694
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Related medicine news :

1. Bariatricfurnishings.com Launches Unique Eco-friendly Seating for Health Care, Hospitality, Assisted Living Centers, and Home Use at Competitive Prices
2. Maximized Living Named as Exclusive Chiropractic Partner of USA Weightlifting
3. Greenwala and PETCO Announce Healthy Living, Healthy Pet Social Media Campaign
4. RetireSafe Survey Says Seniors Are Struggling With Increased Costs Without an Increased Social Security Cost of Living Adjustment
5. Register Online for this Year's Horst Senior Living Conference on April 8 Featuring Keynote Speaker and Senior Housing Expert Jim Moore
6. Nurtur Acquires ActivHealth and Wellness by Choice; Gains Exclusive Partnership with Duke University Center for Living
7. Healthy Aging Global Leader Broadens Patient Exercise/Nutrition Success With Online Living Site
8. iTable Debuts at CeBIT 2010 to Revolutionize Your Living Room
9. KID HEALTHY-Steps to Healthy Living Kicks Off 2010 Campaign to Make Southern California Kids and Families Healthier
10. Regence Invests in Kinetix Living Corp.
11. Wyndemere Senior Living Community Acquired by Life Care Services
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... 2016 , ... Marcy was in a crisis. Her son James, eight, was out of control. ... and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... rocks at my other children and say he was going to kill them. If ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... ANGELES , June 23, 2016 ... CAPR ), a biotechnology company focused ... therapeutics, today announced that patient enrollment in its ... in Duchenne) has exceeded 50% of its 24-patient ... enrollment in the third quarter of 2016, and ...
(Date:6/23/2016)... PARK RIDGE, Ill. and INDIANAPOLIS ... caliber of students receiving a Lilly Diabetes Tomorrow,s Leaders ... hands. The 2016 scholarship winners, announced today online at ... refused to let type 1 diabetes stand in the ... Lilly Diabetes has supported the Foundation,s scholarship program since ...
(Date:6/23/2016)... Pa. , June 23, 2016 The ... in an outpatient dialysis facility.  Treatments are usually 3 ... 6 hours per visit, including travel time, equipment preparation ... a patient, but especially grueling for patients who are ... of a skilled nursing and rehabilitation centers for some ...
Breaking Medicine Technology: