Navigation Links
Liver transplant recipients with hepatitis B may need lifelong antiviral treatment
Date:2/26/2009

Patients who undergo liver transplantation for hepatitis B-related liver damage should receive lifelong antiviral treatment to keep the disease from coming back. A new study shows that they lack cellular immunity against the disease, making recurrence likely if antiviral treatment is withdrawn. These findings are in the March issue of Liver Transplantation, a journal published by John Wiley & Sons. The article is also available online at Wiley Interscience (www.interscience.wiley.com).

Chronic hepatitis B (HBV) is a common cause of advanced liver disease and liver cancer. Liver transplantation is the most effective treatment, however, without ongoing antiviral therapy, HBV recurs in 80 percent of recipients. While the patient's immune system plays a critical role in both viral clearance and liver injury, the role of HBV-specific cellular immunity in liver transplant patients has been unclear.

Researchers, led by Chung Mau Lo, of The University of Hong Kong, set out to understand this immunity in patients with HBV who received a liver transplant. They examined HBV-specific CD4 T-cell immune response in 52 HBV patients who'd undergone liver transplantation. Forty of these patients had experienced HBV recurrence and 12 had not. They compared data from 63 people with HBV who had not undergone transplantation. Forty such patients had chronic HBV and 23 had self-limited infection.

Researchers introduced HBV-encoded antigens to blood samples from each patient. They then determined T-cell proliferation and interferon-γ production in vitro. They found that cellular immunity in transplant recipients with recurrence was not significantly different from that of chronically infected individuals with elevated aminotransferases. However, transplant patients without recurrence had lower or undetectable CD4 T-cell response.

"Our results provide strong evidence to support the conce
'/>"/>

Contact: Sean Wagner
medicalnews@bos.blackwellpublishing.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Advanced Age No Bar to Liver Transplant
2. Researchers Find Better Way to Deliver Blood Thinner
3. Federal research plan to determine nanotech risks fails to deliver
4. Liver cancer marker could yield blood test for early detection
5. Blood Marker Might Help Spot Early Liver Cancer
6. Natural Protein Could Help Spot, Treat Liver Cancer
7. Diet Change Can Curb Fatty Liver Disease
8. US FDA Fast Tracks PI-88 for the Treatment of Post Resection Liver Cancer
9. The American Liver Foundation Appoints Rick Smith, a Twenty-Year Veteran of The MS Society, as Chief Executive Officer
10. Re-plumbing liver helps beat cancer
11. Free Prescription Drug Program Uses Internet to Deliver Cards - Offers Assistance to Uninsured
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... 2014 AttorneyOne.com, a recognized authority on law, ... the FDA on sterile convenience surgical packs . , ... convenience surgical packs, by Customed Inc., are recalled ... for the recall is a potential defect found due to ... and infection. The affected products’ manufacture dates were from January ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 The Florida ... the Hyatt Regency Orlando last week August 21-24 and ... returned as a presenter. , Dr. Greenstein ... the 21st Century was a standing room session; (2) ... – Doctors of Chiropractic Leading the Way in Injury ...
(Date:8/29/2014)... Canadian Healthy Vending , the largest healthy ... survey of its 200 operators from every region of ... appeal to Canadian consumer seeking refreshment at healthy vending ... five selling healthy snacks and top five selling healthy ... for consumers, employers, and families. Everyone wants to eat ...
(Date:8/29/2014)... 29, 2014 The Department of ... Administration (FDA), Center for Food Safety and Applied ... indefinite quantity (IDIQ) contract and the first two ... “Development, Modernization and Enhancement (DME) for FARM VI” ... , Overarching contract objectives include:, , ...
(Date:8/29/2014)... Under Section 946.300, Qualifications for the Certifying Physician, ... not…advertise in a cultivation center or a dispensing organization.” ... of Illinois has done is create a level of ... their care. The goal is to create a level ... typical prescription medications. Medical steering is a serious issue ...
Breaking Medicine News(10 mins):Health News:Sterile Convenience Surgical Packs by Customed, Inc. Recalled: AttorneyOne Monitors and Keeps Consumers Informed 2Health News:Sport and Spine Rehab’s CEO Presents at the Florida Chiropractic Association National Convention and Expo 2014 2Health News:Survey Results: What Products Do Canadians Want in Their Healthy Vending Machines? 2Health News:Survey Results: What Products Do Canadians Want in Their Healthy Vending Machines? 3Health News:Team VersaTech and CRGT Win HHS FDA Contract to Support Food Applications Regulatory Management (FARM) System Upgrade 2Health News:Team VersaTech and CRGT Win HHS FDA Contract to Support Food Applications Regulatory Management (FARM) System Upgrade 3Health News:Medical Marijuana Company Provides Solution for Illinois Marketing Regulations 2
... NANJING, China, Aug. 5 /PRNewswire-Asia/ -- Simcere Pharmaceutical ... supplier of branded generic and,innovative anti-cancer pharmaceuticals in China, ... quarter results on Monday, August 17, 2009,after the market ... Ren, and chief financial officer, Frank Zhigang Zhao, will,host ...
... , FORT LAUDERDALE, Fla., Aug. 5 ... leading provider of convenient at-home diet, fitness and healthy lifestyle solutions, today ... results after the U.S. equity markets close on Wednesday, August 12, 2009. ... conference call for investors the following day, Thursday, August 13, beginning at ...
... , PARSIPPANY, N.J., Aug. 5 DSM ... facility has received the( )Potent Compound Safety Certification from ... The Certification is for competency and proficiency in the ... potent drug products, and applies to the site,s potent ...
... , HACKENSACK, N.J., Aug 5 ReGen Biologics, a ... regarding its Menaflex collagen meniscus implant that were made in a ... party unaffiliated with the company. ReGen was unaware of ... on the Internet. The statements made in the release do ...
... , , , ... Michigan-based company dedicated to providing custom filling solutions, is now manufacturing ... for this product category in the market. The product line includes ... a growing trend in the hand-sanitizer market for more gentle formulas ...
... , SAN FRANCISCO, Aug. 5 ... to a study just published in the Journal of Gerontology ... risk for poor health outcomes and complications from other disorders. ... ongoing study of healthy adults aged 65 and older funded ...
Cached Medicine News:Health News:Simcere Pharmaceutical Group to Announce 2009 Second Quarter Earnings on Monday, August 17, 2009 2Health News:eDiets.com(R) to Report Second Quarter Fiscal 2009 Results on Wednesday, August 12, 2009 2Health News:DSM Announces SafeBridge(R) Potent Compound Safety Certification 2Health News:DSM Announces SafeBridge(R) Potent Compound Safety Certification 3Health News:ReGen Biologics Clarifies Recent Press about the Menaflex Device 2Health News:Brain Fitness Reduces Risk of Onset of Depressive Symptoms 2
(Date:8/28/2014)... Resources Group finds that the market for colorectal cancer (CRC) ... in the United States , ... Italy , Spain , the ... . The biosimilar erosion of Roche/Genentech/Chugai,s Avastin and Bristol-Myers Squibb/Eli ... of Eli Lilly,s Cyramza, Taiho Pharmaceutical,s Lonsurf, Alchemia,s HA-irinotecan and ...
(Date:8/28/2014)... YORK , Aug. 28, 2014 Levi ... been commenced in the United States District Court for ... behalf of investors who purchased Galectin Therapeutics Inc. ("Galectin" ... 2014 and July 28, 2014. For more ... complaint alleges that during the Class Period the Company ...
(Date:8/28/2014)... , Aug. 28, 2014 Nonin Medical, ... leader in noninvasive medical monitoring, today announced that the ... Model 3231 OEM/eHealth finger pulse oximeter for use in ... pulse oximeter plugs into a telemedicine hub or kiosk ... pulse rate in pediatric to adult patients. The Model ...
Breaking Medicine Technology:The Colorectal Cancer Market Will Remain Steady at $7.7 Billion by 2023, With Biosimilar Erosion Of Key Agents Being Balanced Out By the Launch Of Premium-Priced Therapies 2SHAREHOLDER ALERT: Levi & Korsinsky, LLP Reminds Investors of Class Action Against Galectin Therapeutics Inc. and Its Board of Directors and a Lead Plaintiff Deadline of September 29, 2014 -- GALT 2Nonin Medical Announces FDA Clearance of Nonin Model 3231 USB Pulse Oximeter 2
... and Company (NYSE: LLY ) today issued ... and chief executive officer about his meeting today with ... job creation, American innovation and competiveness: "It,s ... and take part in this very important dialogue today ...
... Dec. 15, 2010 Johnson & Johnson (NYSE: ... Worldwide Chairman, Medical Devices & Diagnostics (MD&D) and Sheri ... Chairmen of the Executive Committee and join William C. ... in an expanded Office of the Chairman.  Both appointments ...
Cached Medicine Technology:Lilly Statement Regarding President Obama's Meeting With U.S. Business Leaders 2Johnson & Johnson Announces Executive Appointments: Alex Gorsky, Vice Chairman, Executive Committee Sheri McCoy, Vice Chairman, Executive Committee 2Johnson & Johnson Announces Executive Appointments: Alex Gorsky, Vice Chairman, Executive Committee Sheri McCoy, Vice Chairman, Executive Committee 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: