Navigation Links
Liver transplant recipients with hepatitis B may need lifelong antiviral treatment
Date:2/26/2009

Patients who undergo liver transplantation for hepatitis B-related liver damage should receive lifelong antiviral treatment to keep the disease from coming back. A new study shows that they lack cellular immunity against the disease, making recurrence likely if antiviral treatment is withdrawn. These findings are in the March issue of Liver Transplantation, a journal published by John Wiley & Sons. The article is also available online at Wiley Interscience (www.interscience.wiley.com).

Chronic hepatitis B (HBV) is a common cause of advanced liver disease and liver cancer. Liver transplantation is the most effective treatment, however, without ongoing antiviral therapy, HBV recurs in 80 percent of recipients. While the patient's immune system plays a critical role in both viral clearance and liver injury, the role of HBV-specific cellular immunity in liver transplant patients has been unclear.

Researchers, led by Chung Mau Lo, of The University of Hong Kong, set out to understand this immunity in patients with HBV who received a liver transplant. They examined HBV-specific CD4 T-cell immune response in 52 HBV patients who'd undergone liver transplantation. Forty of these patients had experienced HBV recurrence and 12 had not. They compared data from 63 people with HBV who had not undergone transplantation. Forty such patients had chronic HBV and 23 had self-limited infection.

Researchers introduced HBV-encoded antigens to blood samples from each patient. They then determined T-cell proliferation and interferon-γ production in vitro. They found that cellular immunity in transplant recipients with recurrence was not significantly different from that of chronically infected individuals with elevated aminotransferases. However, transplant patients without recurrence had lower or undetectable CD4 T-cell response.

"Our results provide strong evidence to support the conce
'/>"/>

Contact: Sean Wagner
medicalnews@bos.blackwellpublishing.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Advanced Age No Bar to Liver Transplant
2. Researchers Find Better Way to Deliver Blood Thinner
3. Federal research plan to determine nanotech risks fails to deliver
4. Liver cancer marker could yield blood test for early detection
5. Blood Marker Might Help Spot Early Liver Cancer
6. Natural Protein Could Help Spot, Treat Liver Cancer
7. Diet Change Can Curb Fatty Liver Disease
8. US FDA Fast Tracks PI-88 for the Treatment of Post Resection Liver Cancer
9. The American Liver Foundation Appoints Rick Smith, a Twenty-Year Veteran of The MS Society, as Chief Executive Officer
10. Re-plumbing liver helps beat cancer
11. Free Prescription Drug Program Uses Internet to Deliver Cards - Offers Assistance to Uninsured
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... (PRWEB) September 17, 2014 Kristen Yarker, MSc, ... the parents of children 9 months to 2 years old ... and furthermore, prevent picky eaters from developing by encouraging healthy ... Eating (9 months to 2 years): How to Transition From ... Child Is Getting the Nutrition They Need)” is a new ...
(Date:9/17/2014)... September 17, 2014 Angeldress.co.uk ... of graceful special occasion outfits for worldwide clients. According ... are thinking of opening the first flagship retail store. ... industry. Recently, the company has unveiled its new range ... , All its new products are offered at ...
(Date:9/17/2014)... Calif. (PRWEB) September 17, 2014 ... monthly interruptions, giving girls of all ages an ... wellness company founded by women, for women, announces ... Uninterrupted® (http://GirlU.com) to relieve the symptoms ... bloating and irritability. , As a lifelong ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 In a ... Diego, Dr. William Groff, an expert on the condition known ... Pearly penile papules , or PPP, is a condition ... although other men may be affected as well. The condition ... penis. , “While PPP is not a sexually transmitted ...
(Date:9/17/2014)... A raucous childhood in an Italian-Polish family and ... Nancy Chovancek’s laughter-filled new book, “Angry Birds and Beehive ... stories that prove the best way to deal with ... of empowerment and resilience, everyone can identify with Chovancek’s ... two books under her belt on the topic of ...
Breaking Medicine News(10 mins):Health News:Nutritionist Kristen Yarker Offers Parents a Fresh Approach to Prevent Picky Eaters in New Online Seminar 2Health News:Nutritionist Kristen Yarker Offers Parents a Fresh Approach to Prevent Picky Eaters in New Online Seminar 3Health News:Angeldress.co.uk Is Planning To Open Its First Retail Store And Offering Big Savings On Amazing Wedding Dresses 2Health News:Girl Uninterrupted® Debuts New Look for All-Natural, PMS-Relief Supplement, Launching Today 2Health News:Girl Uninterrupted® Debuts New Look for All-Natural, PMS-Relief Supplement, Launching Today 3Health News:Girl Uninterrupted® Debuts New Look for All-Natural, PMS-Relief Supplement, Launching Today 4Health News:New Video Depicts Best Treatment for PPP 2Health News:New Video Depicts Best Treatment for PPP 3
... genetic risk factors for rheumatoid arthritis (RA) have ... identified so far have been associated with autoantibody-positive ... but distinguishing this variant from autoantibody-negative RA, which ... A new study led by Diane van der ...
... tips from spinal experts helps professionals get back to ... professionals logging long hours at their desks, it,s not ... to Americans suffering from back pain.* This Administrative Professionals ... is helping administrative support professionals find relief. Simple ...
... Expertise to National OrganizationSPRINGFIELD, Va., April 7 ... organization dedicated to supporting those affected by the ... has selected Christine Brown to be its first ... management, program development, fundraising and advocacy relations to ...
... respondents say , , TUESDAY, April 7 (HealthDay News) -- Flavored ... and should carry warning labels, say many American adults who ... sweet drinks made to taste like cola or soda pop ... 8 percent alcohol content, which is a little bit more ...
... LAKE CITY University of Utah researchers have found ... predicting treatment outcomes and measuring disease progression for patients ... disorder that affects more than 3.5 million Americans and ... study on a novel application of this technology for ...
... expectation may be factors in helping older adults ... with the Birmingham Veterans Administration Medical Center and ... published in March in the Annals of ... for surgery returned to normal baseline function more ...
Cached Medicine News:Health News:Genetic risk factors play role in autoantibody-negative rheumatoid arthritis 2Health News:Laser Spine Institute Helps Professionals Take Back Their Lives from Debilitating Back Pain 2Health News:Laser Spine Institute Helps Professionals Take Back Their Lives from Debilitating Back Pain 3Health News:The National PKU Alliance Expands Leadership and Names Christine Brown as Executive Director 2Health News:The National PKU Alliance Expands Leadership and Names Christine Brown as Executive Director 3Health News:Parents Worry That 'Alcopops' Encourage Teen Drinking 2Health News:U study shows MRI-based method holds promise for predicting treatment outcomes in patients with AF 2Health News:VA/UAB study looks at functional decline in older patients after hospitalization 2Health News:VA/UAB study looks at functional decline in older patients after hospitalization 3
(Date:9/16/2014)... NORTHBROOK, Ill. , Sept. 16, 2014 /PRNewswire/ ... a new director of Business Communications & Advocacy, ... Vice President, Business Communications & Advocacy Margaret Long. In ... Astellas, commitment to urology to patient and advocacy ... brand teams on key strategic initiatives. Noland,s appointment ...
(Date:9/16/2014)... KANSAS CITY, Kan. , Sept. 16, 2014 ... ), a pet therapeutics company focused on licensing, ... animals, today announced that it is commencing an ... common stock.  All of the shares are being ... LLC and Barclays are acting as joint book-running ...
(Date:9/16/2014)... 2014 /PRNewswire-iReach/ -- Dan York has been ... of the RTD ® Advanced Wound Care Dressing, ... sales presence in the U.S. Under York,s leadership, GWM ... field sales representatives in new sales territories that will ... add up to 20 sales representatives in major metropolitan ...
Breaking Medicine Technology:Christy Noland to Lead Urology Advocacy and Communications for Astellas 2Aratana Therapeutics, Inc. Announces Proposed Public Offering 2GWM Products, LLC, announces U.S. market expansion. Dan York added as Director of Sales as part of nationwide growth initiative. 2
... Epiphany Biosciences announced,today, the initiation of a Phase ... and management of acute infectious,mononucleosis. Currently, there are ... condition or any other disease caused by,the Epstein-Barr ... spectrum of anti-viral activity,including inhibition of viral replication ...
... 6 Some 5,000 COPD patients will be ... (Alpha-1) in,a study marking a major cooperative effort ... Respiratory Care (AARC)., The principal investigator is ... Pulmonary Medicine, National Jewish Medical and Research Center,in ...
Cached Medicine Technology:Epiphany Biosciences Reports Initiation of Phase 2 Study of Valomaciclovir for the Treatment of Acute Infectious Mononucleosis 2Alpha-1 Foundation, AARC Cooperate on Study to Test 5,000 COPD Patients for Alpha-1 2Alpha-1 Foundation, AARC Cooperate on Study to Test 5,000 COPD Patients for Alpha-1 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: