Navigation Links
Liver mitochondria improve, increase after chronic alcohol feeding in mice
Date:12/21/2012

Scientists at the Keck School of Medicine of the University of Southern California (USC) have found evidence that liver mitochondria in mice adapt to become better metabolizers of alcohol and increase in number after chronic exposure, which may raise the potential for free radical damage associated with aging and cancer over time.

The liver is a vital organ, playing a major role in metabolism and detoxification in the body. Overconsumption of alcohol has long been tied to liver diseases such as fatty liver, alcoholic hepatitis and cirrhosis, but how the substance damages the organ is not fully understood. USC research published in the Dec. 7, 2012, issue of the Journal of Biological Chemistry, a peer-reviewed scientific journal, suggests that mitochondria play an important role in the liver's response to the metabolic stress caused by alcohol intake. If scientists observe the same results in human mitochondria, it could help pinpoint targets for therapy.

"The liver has to adapt quickly to various toxins and drugs to meet the demands we place on the body," said Derick Han, Ph.D., assistant professor of research medicine at the Keck School of Medicine of USC and first author of the study. "We've found that mitochondrial plasticity the mitochondria's ability to change is probably central to the liver's response to alcohol intake. This gives us a better understanding of how the liver works and how it adapts to stress."

Mitochondria are cellular organelles that generate most of the cell's energy; they have been implicated in certain neurological disorders and have been tied to aging. The metabolism of oxygen by the mitochondria normally generates reactive oxygen species, or free radicals, which in excess can be highly damaging to cells.

"In the short term, it looks like mitochondria adapt to metabolize alcohol better, but as they increase in number and use more oxygen to help metabolize that alcohol, it could be harmful to the body," Han said.

Han and his team of scientists fed alcohol to mice over four weeks, isolated the liver mitochondria and measured levels of respiration and changes in the mitochondrial structure. They found significant increases in oxygen consumption by mice fed the alcohol in comparison to control mitochondria as early as one week after feeding. Changes were greater and more extensive with higher alcohol intake.


'/>"/>
Contact: Alison Trinidad
alison.trinidad@usc.edu
323-442-3941
University of Southern California - Health Sciences
Source:Eurekalert

Related medicine news :

1. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
2. CT Scans Deliver More Radiation to Obese People: Study
3. Modest alcohol consumption lowers risk and severity of liver disease
4. Childhood Obesity May Raise Odds of Adult Liver Cancer
5. UNC study shows potential to revive abandoned cancer drug by nanoparticle drug delivery
6. Combination of 2 drugs reverses liver tumors
7. New guidelines deliver concise messages for implementing cardiovascular prevention
8. Liver fat gets a wake-up call that maintains blood sugar levels
9. Hepatitis C Causing Liver Damage in Greater Numbers: Study
10. Body Building, Diet Supplements Linked to Liver Damage: Study
11. U.S. Liver Transplants Declining
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... ... 27, 2017 , ... Much attention has been paid to the problem of ... opioid painkillers has fallen short. From 1999 until 2010, fatal overdoses from prescription pain ... overdoses in male populations.(1) , The proportion of women using illicit drugs is also ...
(Date:2/27/2017)... ... 2017 , ... Elisa Guajardo Carothers is not your typical author. She went from working as ... Now, she writes about God, when she isn’t swimming as a performing mermaid. , Her ... BS! (Before Satan),” she offers a comedic look at the dysfunctions of God’s family, before ...
(Date:2/27/2017)... ... February 27, 2017 , ... ... on laser diffraction analysis as a tool to characterize particle size distributions in ... to obtain improved results and novel scientific findings. It describes methods of optimized ...
(Date:2/27/2017)... POUGHKEEPSIE, N. Y. (PRWEB) , ... February 27, 2017 , ... ... Society ( ILADS ) has disclosed that despite scientific studies, the Center for Disease ... of chronic Lyme disease . Kenneth B. Liegner, M.D. has compiled into ...
(Date:2/27/2017)... , ... February 27, 2017 , ... ... and alcohol treatment programs in British Columbia, Canada, at https://www.sunshinecoasthealthcentre.ca/ , is ... team. The new hire, Mackenzie Alsager, showcases the Centre's commitment to innovation in ...
Breaking Medicine News(10 mins):
(Date:2/28/2017)... 27, 2017  Market Research presents an all-encompassing and one ... market titled ,Medical Fiber Optics Market: Global Industry Analysis and ... globally across the five key regions of North ... Europe , APAC and MEA which influence the ... optics market over the forecast period. In this report, Persistence ...
(Date:2/28/2017)... TRIANGLE PARK, N.C. , Feb. 28, 2017 ... that Martine Rothblatt , Ph.D., Chairman and Chief Executive ... on the company,s business at the Cowen and Company 37 ... Massachusetts . The presentation will take place ... and can be accessed via a live webcast on the ...
(Date:2/28/2017)... 27, 2017  Clarivate Analytics marks the passing of one if its ... contributions to information science in the service of scientific and scholarly research. ... an indexing system that revolutionized the way researchers work with the literature, ... Continue Reading ... ...
Breaking Medicine Technology: